Evidence

These uses have been tested in humans or animals.  Safety and effectiveness have not always been proven.  Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Key to grades

A
Strong scientific evidence for this use
B
Good scientific evidence for this use
C
Unclear scientific evidence for this use
D
Fair scientific evidence against this use (it may not work)
F
Strong scientific evidence against this use (it likely does not work)

Grading rationale

Evidence gradeCondition to which grade level applies
A

High cholesterol

Niacin is a well-accepted treatment for high cholesterol. Multiple studies show that niacin (not niacinamide) has benefits on levels of high-density cholesterol (HDL or "good cholesterol"), with better results than drugs such as "statins" like atorvastatin (Lipitor®). There are also benefits on levels of low-density cholesterol (LDL or "bad cholesterol"), although these effects are less dramatic. Adding niacin to a second drug such as a statin may increase the effects on low-density lipoproteins. The use of niacin for the treatment of high cholesterol associated with type 2 diabetes has been controversial because of the possibility of worsening blood sugar control. People should check with a physician and pharmacist before starting niacin.
A

Pellagra

Niacin (vitamin B3) and niacinamide are U.S. Food and Drug Administration (FDA)-approved for the treatment of pellagra, or niacin deficiency. Pellagra is a nutritional disease that occurs due to insufficient dietary amounts of vitamin B3 or the chemical it is made from (tryptophan). Symptoms of pellagra include skin disease, diarrhea, dementia, and depression.
B

Clogged arteries

Niacin decreases blood levels of cholesterol, which may reduce the risk of clogged or hardened arteries. However, niacin also can increase homocysteine levels, which may have the opposite effect. Overall, the research supports the use of niacin in combination with other drugs to reduce the risk of clogged arteries. More research is needed in this area before a firm conclusion can be drawn.
B

Heart disease

Niacin decreases levels of cholesterol, and other chemicals in the blood, which can reduce the risk of heart disease. However, niacin also increases homocysteine levels, which can increase this risk. Research has shown beneficial effects of niacin, especially in combination with other drugs, for preventing heart disease and fatal heart attacks. Further study is needed to draw conclusions.
C

Age-related macular disease (eye disease)

Early evidence suggests that niacin may have beneficial effects in age-related macular degeneration (AMD), a disease that often leads to vision loss. More well-designed studies are needed for conclusions to be reached.
C

Alzheimer's disease (mental decline)

Dementia can be caused by a severe lack of niacin in the body. Early evidence suggests that taking more niacin in the diet may slow the onset of Alzheimer's disease and mental decline. Further research is needed before a conclusion can be drawn.
C

Erectile dysfunction

Early research suggests that niacin has a beneficial effect on erectile dysfunction. However, further well-controlled studies are needed to draw conclusions.
C

Headaches

Early research shows that niacin may be beneficial in the treatment or prevention of headaches. More research is needed.
C

Hepatitis C

Early research suggests that niacin may decrease blood levels of hepatitis C, a virus that damages the liver. Notably, niacin has been also associated with liver damage. Further research is necessary for a conclusion to be made.
C

High blood phosphorous level

Early evidence shows that niacinamide had reduced high phosphate levels in the blood. However, more research is needed before a firm conclusion can be made.
C

Osteoarthritis (niacinamide)

Early research suggests that niacinamide may be useful in the treatment of osteoarthritis. Further research is needed before a conclusion can be made.
C

Skin conditions

Niacinamide has been used in skin care products, including moisturizers, anti-aging products, and treatments for rosacea, a skin condition involving facial redness and pimples. The benefits of niacinamide in skin care needs to be further studied before conclusions can be made.
C

Type 1 diabetes (slowing progression)

Non-human research shows that niacinamide delays the onset of insulin dependence in type 1 diabetes. However, human research assessing whether niacinamide slows progression of type 1 diabetes has yielded unclear results. Further study is needed for conclusions to be reached.
C

Type 2 diabetes

Limited research shows unclear effects of niacin on outcomes of type 2 diabetes. Human research has also shown that niacin increases blood sugar levels. People should seek medical advice before starting niacin. Further research is needed to draw conclusions.
D

Type 1 diabetes mellitus prevention (niacinamide)

In human research, niacinamide lacked an effect on the development of diabetes (type 1). Evidence is mixed and more study is needed in this area.

Uses based on tradition or theory

The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Alcohol dependence, anemia (lack of red blood cells), anti-aging, antioxidant, anxiety, arthritis, Bell's palsy (face paralysis), blood thinner, bone marrow suppression (results in decreased blood cells), breast cancer, bursitis (joint inflammation), cancer prevention, cancer treatment side-effects, cataract prevention, chest pain, chronic diarrhea/hypokalemia (long-term diarrhea resulting in low potassium levels), circulatory/blood flow disorders, coronary artery (heart) disease, cosmetic uses, dementia (confusion), depression, diabetes mellitus (type 1) treatment, diabetic complications (high cholesterol), diarrhea, digestion improvement, dizziness, drug-induced hallucinations, swelling, encephalopathy (brain disease), erythema induratum (skin disorder), glossitis (inflamed tongue), growth, heart attack prevention, hearing loss, hepatic encephalopathy (confused thinking due to liver disorders), high blood pressure, HIV, hyperactivity (abnormally active), hyperkinesis (excessive movement), infectious diarrhea (choleric), insomnia, intermittent claudication (leg pain from clogged arteries), ischemia-reperfusion injury prevention (protection from injury caused by lack of blood flow), itching, leprosy (fatal infection), liver disease, liver cancer, lupus (cholesterol abnormalities), memory enhancement, Meniere's syndrome (inner ear disorder), menstrual pain, metabolic syndrome, migraine headache, motion sickness, multiple sclerosis (disease of the nervous system), nervous system disorders, nutrition, obesity (too much body fat), pain, painful menstruation, pancreatitis (inflamed pancreas), parasite infection, Parkinson's disease, peripheral vascular disease (blocked arteries in the legs), polymorphous light eruption (skin disorder due to sunlight), pregnancy, premenstrual syndrome (PMS), prostate cancer, psoriasis, psychosis, Raynaud's disease (reduced blood flow to extremities), ringing in the ears, schizophrenia (for identifying the disease), scleroderma (scar tissue build-up on skin), sedative, seizure disorder, sexual arousal (orgasm improvement), skin inflammation, sleep quality, smoking cessation, stroke, sun protection, swelling, tardive dyskinesia (involuntary movements), taste disturbances, thyroid disorders, tuberculosis, vasculitis (erythema diutinum), ulcers, vascular spasm (blood vessels), vertigo, wound healing.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com