Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Nubain

Descriptions


Nalbuphine injection is used to relieve moderate to severe pain. It may also be given before and after a surgery or with a general anesthesia before an operation. It may also be used to relieve pain while giving birth.

Nalbuphine injection belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

When a nalbuphine injection is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nalbuphine injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of nalbuphine injection in geriatric patients.

Pregnancy

Information about this nalbuphine-injection-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Alphaprodine
  • Carbinoxamine
  • Codeine
  • Dihydrocodeine
  • Fentanyl
  • Fospropofol
  • Hydrocodone
  • Hydromorphone
  • Levorphanol
  • Meclizine
  • Meperidine
  • Methadone
  • Morphine
  • Morphine Sulfate Liposome
  • Oxycodone
  • Oxymorphone
  • Propoxyphene
  • Sufentanil
  • Suvorexant
  • Tapentadol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Perampanel

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, history of or
  • Breathing problems (e.g., asthma) or
  • Drug dependence, especially narcotic abuse or dependence, or history of—Use with caution. May increase risk for more serious side effects.
  • Brain tumor or
  • Head injuries or
  • Increased pressure in the head—Some of the side effects of nalbuphine injection can cause serious problems in people who have these medical problems.
  • Bradycardia (slow heartbeat) or
  • Heart attack or
  • Respiratory depression (hypoventilation or slow breathing)—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot under your skin, into a muscle, or through a needle placed in one of your veins.

Precautions

It is very important that your doctor check your progress while you are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the other medicines listed above while you are using this medicine.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve dizziness or lightheadedness.

This medicine may make you dizzy, drowsy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

Do not change your dose or suddenly stop using this medicine without first checking with your doctor. Your doctor may want to gradually reduce the amount of medicine given to you before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

  1. Chest pain or discomfort
  2. difficult or labored breathing
  3. difficulty swallowing
  4. fainting
  5. false beliefs that cannot be changed by facts
  6. fast, pounding, or irregular heartbeat or pulse
  7. puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  8. redness of the face, neck, arms and occasionally, upper chest
  9. seeing, hearing, or feeling things that are not there
  10. sense of detachment from self or body
  11. shortness of breath
  12. slow or irregular heartbeat
  13. wheezing

Incidence not known

  1. Blue lips and fingernails
  2. convulsions
  3. coughing that sometimes produces a pink frothy sputum
  4. decrease in consciousness
  5. difficult, fast, or noisy breathing, sometimes with wheezing
  6. fear or nervousness
  7. fever
  8. hyperventilation
  9. increased sweating
  10. loss of bladder control
  11. muscle spasm or jerking of all extremities
  12. pale skin
  13. shakiness in legs, arms, hands, or feet
  14. sleepiness or unusual drowsiness
  15. stomach pain
  16. sudden loss of consciousness
  17. swelling in legs and ankles
  18. trembling or shaking of hands or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Dizziness or lightheadedness
  2. drowsiness
  3. feeling of constant movement of self or surroundings
  4. nausea
  5. relaxed and calm
  6. sensation of spinning
  7. sleepiness
  8. sweaty, clammy skin
  9. vomiting

Less common

  1. Dry mouth
  2. Headache

Rare

  1. Acid or sour stomach
  2. aggressive or angry
  3. belching
  4. blurred vision
  5. burning
  6. changes in speech
  7. confusion
  8. cough
  9. discouragement
  10. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  11. dysphoria
  12. excessive crying
  13. false or unusual sense of well-being
  14. feeling of heaviness
  15. feeling of warmth
  16. feeling sad or empty
  17. floating feeling
  18. frequent strong or increased urge to urinate
  19. headache
  20. heartburn
  21. hives or welts
  22. indigestion
  23. irritability
  24. itching of skin
  25. lack of appetite
  26. loss of interest or pleasure
  27. nervousness
  28. numbness
  29. pounding in the ears
  30. restlessness
  31. skin rash
  32. slow or fast heartbeat
  33. stomach discomfort, upset, or pain
  34. tiredness
  35. trouble concentrating
  36. trouble sleeping
  37. tingling feeling of unreality
  38. unusual tiredness or weakness

Incidence not known

  1. Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.