Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

1. Corzide

Descriptions

Nadolol and bendroflumethiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nadolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

Bendroflumethiazide is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nadolol and bendroflumethiazide combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nadolol and bendroflumethiazide combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving nadolol and bendroflumethiazide combination.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albuterol
• Amtolmetin Guacil
• Arsenic Trioxide
• Aspirin
• Bepridil
• Bromfenac
• Bufexamac
• Buprenorphine
• Celecoxib
• Ceritinib
• Choline Salicylate
• Clonidine
• Clonixin
• Codeine
• Crizotinib
• Darunavir
• Deslanoside
• Desmopressin
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Digitalis
• Digitoxin
• Digoxin
• Diltiazem
• Dipyrone
• Dofetilide
• Dronedarone
• Droperidol
• Droxicam
• Epinephrine
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoldopam
• Fenoprofen
• Fepradinol
• Feprazone
• Fexinidazole
• Fingolimod
• Flecainide
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Formoterol
• Ibuprofen
• Indacaterol
• Indomethacin
• Iobenguane I 131
• Iohexol
• Itraconazole
• Ketanserin
• Ketoprofen
• Ketorolac
• Lacosamide
• Levalbuterol
• Levomethadyl
• Lidocaine
• Lithium
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Metildigoxin
• Morniflumate
• Nabumetone
• Naproxen
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oliceridine
• Olodaterol
• Oxaprozin
• Oxymetazoline
• Oxyphenbutazone
• Parecoxib
• Phenylbutazone
• Piketoprofen
• Piroxicam
• Ponesimod
• Porfimer
• Proglumetacin
• Propyphenazone
• Proquazone
• Rivastigmine
• Rofecoxib
• Salicylic Acid
• Salmeterol
• Salsalate
• Siponimod
• Sodium Salicylate
• Sotalol
• Sufentanil
• Sulindac
• Tapentadol
• Tenoxicam
• Terbutaline
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Tramadol
• Valdecoxib
• Verapamil
• Vilanterol
• Vonoprazan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albiglutide
• Alfuzosin
• Alogliptin
• Aminolevulinic Acid
• Amtolmetin Guacil
• Aspirin
• Bromfenac
• Bufexamac
• Bunazosin
• Canagliflozin
• Celecoxib
• Chlorpropamide
• Choline Salicylate
• Clonixin
• Dapagliflozin
• Deslanoside
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Digitoxin
• Digoxin
• Dipyrone
• Doxazosin
• Droxicam
• Dulaglutide
• Empagliflozin
• Ertugliflozin
• Etodolac
• Etofenamate
• Etoricoxib
• Exenatide
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Ginkgo
• Glimepiride
• Glipizide
• Glyburide
• Gossypol
• Ibuprofen
• Indomethacin
• Insulin Aspart, Recombinant
• Insulin Degludec
• Insulin Detemir
• Insulin Glargine, Recombinant
• Insulin Glulisine
• Insulin Human Inhaled
• Insulin Human Isophane (NPH)
• Insulin Human Regular
• Insulin Lispro, Recombinant
• Ketoprofen
• Ketorolac
• Licorice
• Linagliptin
• Liraglutide
• Lixisenatide
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Metformin
• Metildigoxin
• Miglitol
• Morniflumate
• Moxisylyte
• Nabumetone
• Naproxen
• Nateglinide
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenelzine
• Phenoxybenzamine
• Phentolamine
• Phenylbutazone
• Piketoprofen
• Pioglitazone
• Piroxicam
• Pramlintide
• Pranoprofen
• Prazosin
• Proglumetacin
• Propyphenazone
• Proquazone
• Repaglinide
• Rofecoxib
• Rosiglitazone
• Salicylic Acid
• Salsalate
• Saxagliptin
• Sitagliptin
• Sodium Salicylate
• St John's Wort
• Sulindac
• Tamsulosin
• Tenoxicam
• Terazosin
• Tiaprofenic Acid
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Trimazosin
• Urapidil
• Valdecoxib
• Vildagliptin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Green Tea

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (severe chest pain)—May provoke chest pain if stopped too quickly.

• Anuria (not able to form urine) or
• Asthma or
• Bradycardia (slow heartbeat) or
• Cardiogenic shock (shock caused by heart attack) or
• Heart block or
• Heart failure or
• Sulfa drug allergy (eg, sulfamethoxazole, Bactrim®, Septra®)—Should not be used in patients with these conditions.

• Blood vessel disease or circulation problems (eg, coronary artery disease) or
• Electrolyte imbalance (eg, high calcium or low chloride, magnesium, potassium, sodium in the body) or
• Glaucoma, acute angle-closure or
• Gout or
• Hyperuricemia (high uric acid in the blood) or
• Myopia (changes in the eyeball causing vision problems), acute or
• Parathyroid disease or
• Systemic lupus erythematosus—Use with caution. This medicine may make these conditions worse.

• Diabetes or
• Hyperthyroidism (overactive thyroid) or
• Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat.

• Kidney disease, severe or
• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Lung disease (eg, bronchitis, emphysema)—Use with caution. May cause difficulty with breathing in patients with this condition.

• Sympathectomy—Use with caution. The effects of this medicine may be increased.

Proper Use

This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the tablet whole. Do not crush, break, or chew it.

If you are also taking cholestyramine (Questran®) or colestipol (Colestid®), take Corzide® at least 1 hour before or 4 to 6 hours after these medicines.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  • For high blood pressure:
    • Adults—At first, one tablet once a day. Your doctor may adjust your dose if needed.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause or worsen heart failure in some patients. Check with your doctor right away if you have chest pain or discomfort, dilated neck veins, irregular breathing, an irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, weight gain, or unusual tiredness or weakness.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

Check with your doctor right away if you start having dry mouth, increased thirst, muscle cramps, nausea or vomiting, unusual tiredness or weakness, severe drowsiness or dizziness, seizures, a decrease in urine, or a fast heartbeat while you are using this medicine. These may be symptoms of dehydration or mineral imbalance.

Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

1. Blurred vision
2. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
3. chest pain, tightness, or discomfort
4. confusion
5. cough
6. difficulty breathing
7. dilated neck veins
8. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
9. irregular breathing
10. lightheadedness, dizziness, or fainting
11. noisy breathing
12. paleness or cold feeling in fingertips and toes
13. slow or irregular heartbeat
14. slurred speech
15. sweating
16. swelling of face, fingers, feet, or lower legs
17. tingling or pain in fingers or toes when exposed to cold
18. unusual tiredness or weakness
19. weight gain

Incidence not known

1. Back or leg pains
2. black, tarry stools
3. bleeding gums
4. bloating
5. blood in urine or stools
6. chills
7. clay-colored stools
8. cloudy urine
9. cold sweats
10. constipation
11. coughing up blood
12. dark urine
13. difficulty swallowing
14. drowsiness
15. dry mouth
16. fast heartbeat
17. fever
18. flushed, dry skin
19. fruit-like breath odor
20. general body swelling
21. general feeling of discomfort or illness
22. general tiredness and weakness
23. headache
24. hives, skin rash
25. hoarseness
26. increased hunger
27. increased thirst
28. increased urination
29. indigestion
30. joint pain, stiffness, or swelling
31. light-colored stools
32. loss of appetite
33. lower back or side pain
34. muscle tremors
35. nausea and vomiting
36. nosebleeds
37. pain in the muscles
38. painful or difficult urination
39. pains in stomach, side, or abdomen, possibly radiating to the back
40. pale skin
41. pinpoint red spots on the skin
42. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
43. rapid, deep breathing
44. redness, soreness, or itching skin
45. restlessness
46. sore throat
47. sores, ulcers, or white spots on the lips or in the mouth
48. sores, welting, or blisters
49. stomach cramps
50. sugar in the urine
51. swollen or painful glands
52. tenderness of salivary glands
53. thickening of bronchial secretions
54. trouble breathing
55. unpleasant breath odor
56. unusual bleeding or bruising
57. unusual weight loss
58. upper right stomach pain
59. vomiting of blood
60. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

1. Change in consciousness
2. decreased urination
3. diarrhea
4. fast, slow, or shallow breathing
5. gas
6. heartburn
7. increase in heart rate
8. increased sweating
9. indigestion
10. loss of consciousness
11. low blood pressure
12. muscle cramps
13. numbness, tingling, pain, or weakness in the hands or feet
14. pale or blue lips, fingernails, or skin
15. seizures
16. sunken eyes
17. trembling
18. unusual drowsiness, dullness, or feeling of sluggishness
19. unusual paleness
20. weakness and heaviness of the legs
21. wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

1. Change in behavior
2. continuing ringing or buzzing or other unexplained noise in the ears
3. decreased interest in sexual intercourse
4. dry eyes or skin
5. excess air or gas in stomach or intestines
6. hair loss, thinning of hair
7. hearing loss
8. inability to have or keep an erection
9. loss in sexual ability, desire, drive, or performance
10. relaxed and calm
11. sleepiness
12. stomach soreness or discomfort
13. stuffy nose
14. weight loss

Incidence not known

1. Cracks in the skin
2. discoloration of skin
3. feeling of constant movement of self or surroundings
4. increased sensitivity of skin to sunlight
5. large, flat, blue or purplish patches in the skin
6. loss of heat from the body
7. muscle spasm, weakness, or restlessness
8. scaly skin
9. sensation of spinning
10. severe sunburn

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/nadolol-and-bendroflumethiazide-oral-route/proper-use/drg-20071217