Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Avelox IV

Descriptions


Moxifloxacin injection is used to treat bacterial infections in many different parts of the body.

Moxifloxacin belongs to the class of medicines known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of moxifloxacin injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of moxifloxacin injection in the elderly. However, elderly patients are more likely to have age-related heart problems, or develop severe tendon problems (including tendon rupture), which may require caution in patients receiving moxifloxacin injection.

Pregnancy

Information about this moxifloxacin-intravenous-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Cisapride
  • Dronedarone
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Sparfloxacin
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acetohexamide
  • Acetophenazine
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Apomorphine
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Azithromycin
  • Bedaquiline
  • Benfluorex
  • Bretylium
  • Buserelin
  • Chloroquine
  • Chlorpromazine
  • Chlorpropamide
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Dasatinib
  • Delamanid
  • Desipramine
  • Deslorelin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Dothiepin
  • Doxepin
  • Droperidol
  • Erythromycin
  • Escitalopram
  • Ethopropazine
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluphenazine
  • Formoterol
  • Gatifloxacin
  • Gemifloxacin
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Guar Gum
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Lofepramine
  • Lopinavir
  • Lumefantrine
  • Mefloquine
  • Metformin
  • Methadone
  • Methotrimeprazine
  • Mifepristone
  • Miglitol
  • Moricizine
  • Nafarelin
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Opipramol
  • Paliperidone
  • Pasireotide
  • Pazopanib
  • Perflutren Lipid Microsphere
  • Perphenazine
  • Pipotiazine
  • Posaconazole
  • Procainamide
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propafenone
  • Propiomazine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Salmeterol
  • Saquinavir
  • Sertraline
  • Sevoflurane
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sunitinib
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Thiethylperazine
  • Tizanidine
  • Tolazamide
  • Tolbutamide
  • Toremifene
  • Trazodone
  • Trifluoperazine
  • Triflupromazine
  • Trimeprazine
  • Trimipramine
  • Triptorelin
  • Troglitazone
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Betamethasone
  • Corticotropin
  • Cortisone
  • Cosyntropin
  • Deflazacort
  • Dexamethasone
  • Fludrocortisone
  • Fluocortolone
  • Hydrocortisone
  • Methylprednisolone
  • Paramethasone
  • Prednisolone
  • Prednisone
  • Rifampin
  • Triamcinolone

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bradycardia (slow heartbeat) or
  • Diarrhea or
  • Heart disease or
  • Heart rhythm problems (eg, prolonged QT interval), or family history of or
  • Hypokalemia (low potassium in the blood) or
  • Seizures (epilepsy), history of—Use with caution. May make these conditions worse.
  • Brain disease (eg, hardening of the arteries) or
  • Kidney disease or
  • Liver disease (including cirrhosis) or
  • Organ transplant (eg, heart, kidney, or lung), history of or
  • Tendon disorder (eg, rheumatoid arthritis), history of—Use with caution. May cause side effects to become worse.
  • Myasthenia gravis (severe muscle weakness), or history of—Should not be used in patients with this condition.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

Your doctor may give you a few doses of this medicine until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Precautions

It is very important that your doctor check your progress while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

If you have low potassium levels in the blood, moxifloxacin may increase your risk of having a fast, slow or irregular heartbeat, loss of consciousness, or fainting spells. If these symptoms occur, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive this medicine.

Moxifloxacin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Tell your doctor right away if you start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

Moxifloxacin may rarely cause inflammation (tendinitis) or tearing of a tendon (the cord that attaches muscles to bones). This can occur while you are using the medicine or after you finish using it. The risk of having tendon problems may be increased if you are over 60 years of age, are using steroid medicines (eg, dexamethasone, prednisolone, prednisone, or Medrol®), have severe kidney problems, have a history of tendon problems (eg, rheumatoid arthritis), or if you have received an organ transplant (eg, heart, kidney, or lung). Check with your doctor right away if you have sudden pain or swelling in a tendon after exercise (eg, ankle, back of the knee or leg, shoulder, elbow, or wrist), bruise more easily after an injury, or are unable to bear weight or move the affected area. Refrain from exercise until your doctor says otherwise.

Moxifloxacin may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If these reactions are especially bothersome, check with your doctor.

Some people who receive moxifloxacin may become more sensitive to sunlight than normal. Exposure to sunlight, even for brief periods of time, may cause severe sunburn, or skin rash, redness, itching, or discoloration. When you begin receiving this medicine:

  • Stay out of direct sunlight, especially between the hours of 10 AM and 3 PM, if possible.
  • Wear protective clothing, including a hat and sunglasses.
  • Apply a sun block product that has a sun protection factor (SPF) of at least 15. Some people may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
  • Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

  1. Abdominal or stomach cramps
  2. abdominal or stomach tenderness
  3. black, tarry stools
  4. bleeding gums
  5. bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  6. blisters
  7. bloating or swelling of the face, arms, hands, lower legs, or feet
  8. blood in the urine or stools
  9. blurred vision
  10. bone pain
  11. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  12. chest pain
  13. chills
  14. clay-colored stools
  15. cough
  16. crying
  17. dark urine
  18. diarrhea, watery and severe, which may also be bloody
  19. difficult or labored breathing
  20. difficulty with moving
  21. difficulty with swallowing
  22. discouragement
  23. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  24. dry mouth
  25. excessive muscle tone
  26. fainting
  27. fast, irregular, pounding, or racing heartbeat or pulse
  28. feeling of unreality
  29. feeling of warmth or heat
  30. feeling sad or empty
  31. fever
  32. flushed, dry skin
  33. flushing or redness of the skin, especially on the face and neck
  34. fruit-like breath odor
  35. headache
  36. hyperventilation
  37. increased hunger
  38. increased sensitivity of the skin to sunlight
  39. increased thirst
  40. increased urination
  41. irregular heartbeat recurrent
  42. irritability
  43. itching
  44. joint pain, stiffness, or swelling
  45. lack of coordination
  46. loss of appetite
  47. loss of interest or pleasure
  48. lower back, side, or stomach pain
  49. mood or mental changes
  50. muscle aching or cramping
  51. muscle pains or stiffness
  52. muscle tension or tightness
  53. nausea or vomiting
  54. nervousness
  55. noisy breathing
  56. pain
  57. pain in the pelvis
  58. pain, warmth, or burning in the fingers, toes, and legs
  59. painful or difficult urination
  60. painful, swollen joints
  61. pale skin
  62. pinpoint red spots on the skin
  63. pounding in the ears
  64. problems with speech or speaking
  65. problems with vision or hearing
  66. quick to react or overreact emotionally
  67. rapid weight gain
  68. rapidly changing moods
  69. redness or other discoloration of the skin
  70. restlessness
  71. seeing, hearing, or feeling things that are not there
  72. seizures
  73. sensation of the skin burning
  74. sense of detachment from self or body
  75. severe sunburn
  76. shakiness in the legs, arms, hands, or feet
  77. skin rash
  78. sore throat
  79. sores, ulcers, or white spots on the lips or in the mouth
  80. sweating
  81. swelling of the feet or lower legs
  82. swelling or puffiness of the face
  83. swollen glands
  84. tightness in the chest
  85. tingling of the hands or feet
  86. tiredness
  87. trouble concentrating
  88. trouble sleeping
  89. troubled breathing with exertion
  90. unexplained weight loss
  91. unpleasant breath odor
  92. unusual bleeding or bruising
  93. unusual tiredness or weakness
  94. unusual weight gain or loss
  95. vomiting of blood
  96. yellow eyes or skin

Incidence not known

  1. Blistering, peeling, or loosening of the skin
  2. burning, numbness, tingling, or painful sensations
  3. change in the ability to see colors, especially blue or yellow
  4. confusion as to time, place, or person
  5. difficulty in chewing or talking
  6. double vision
  7. drooping eyelids
  8. eye pain
  9. general feeling of tiredness or weakness
  10. hives
  11. hoarseness
  12. irregular or slow heart rate
  13. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  14. light-colored stools
  15. muscle weakness
  16. no blood pressure or pulse
  17. puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  18. red, irritated eyes
  19. red skin lesions, often with a purple center
  20. severe headache
  21. severe tiredness
  22. stomach pain, continuing
  23. stopping of heart
  24. unconsciousness
  25. unsteadiness or awkwardness
  26. unusual excitement, nervousness, or restlessness
  27. weakness in the arms, hands, legs, or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  1. Acid or sour stomach
  2. bad, unusual, or unpleasant (after) taste
  3. belching
  4. burning feeling in the chest or stomach
  5. change in sense of smell
  6. change in taste
  7. changes in vision
  8. continuing ringing or buzzing or other unexplained noise in the ears
  9. difficulty having a bowel movement (stool)
  10. excess air or gas in the stomach or intestines
  11. fear or nervousness
  12. feeling of constant movement of self or surroundings
  13. full feeling
  14. general feeling of discomfort or illness
  15. hearing loss
  16. heartburn
  17. impaired vision
  18. indigestion
  19. itching of the vagina or genital area
  20. lack or loss of strength
  21. loss of memory
  22. pain during sexual intercourse
  23. passing of gas
  24. problems with memory
  25. redness, swelling, or soreness of the tongue
  26. sensation of spinning
  27. sleepiness or unusual drowsiness
  28. sore mouth or tongue
  29. stomach discomfort, upset, or pain
  30. swelling or inflammation of the mouth
  31. thick, white vaginal discharge with no odor or with a mild odor
  32. vaginal yeast infection
  33. white patches in the mouth and/or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.