Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. DepoDur

Descriptions


Morphine epidural injection is used to relieve pain following a major surgery. It is given right before a surgery or during a cesarean section delivery right after the baby's umbilical cord is clamped.

Morphine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

This medicine is available only with your doctor's prescription and will be given by or under the immediate supervision of your doctor.

This product is available in the following dosage forms:

  • Suspension, Extended Release

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of morphine epidural injection in the pediatric population. Use of morphine epidural injection is not recommended in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of morphine epidural injection in the elderly. However, elderly patients are more likely to have age-related heart, stomach, or lung problems, which may require caution and an adjustment in the dose for patients receiving morphine epidural injection.

Pregnancy

Information about this morphine-epidural-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adinazolam
  • Alfentanil
  • Alprazolam
  • Anileridine
  • Brofaromine
  • Bromazepam
  • Brotizolam
  • Buprenorphine
  • Butalbital
  • Butorphanol
  • Carbinoxamine
  • Carisoprodol
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorpromazine
  • Chlorzoxazone
  • Cimetidine
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Clorgyline
  • Codeine
  • Dantrolene
  • Dezocine
  • Diazepam
  • Droperidol
  • Estazolam
  • Ethchlorvynol
  • Fentanyl
  • Flunitrazepam
  • Fluphenazine
  • Flurazepam
  • Furazolidone
  • Halazepam
  • Hydrocodone
  • Hydromorphone
  • Iproniazid
  • Isocarboxazid
  • Ketazolam
  • Lazabemide
  • Levorphanol
  • Linezolid
  • Lorazepam
  • Lormetazepam
  • Meclizine
  • Medazepam
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Meptazinol
  • Metaxalone
  • Methocarbamol
  • Methohexital
  • Midazolam
  • Moclobemide
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Nialamide
  • Nitrazepam
  • Nordazepam
  • Opium
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Pargyline
  • Pentazocine
  • Perphenazine
  • Phenelzine
  • Prazepam
  • Procarbazine
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propoxyphene
  • Quazepam
  • Rasagiline
  • Remifentanil
  • Selegiline
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Toloxatone
  • Tranylcypromine
  • Triazolam
  • Trifluoperazine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Chloroprocaine
  • Cyclosporine
  • Epinephrine
  • Esmolol
  • Gabapentin
  • Lidocaine
  • Perampanel
  • Rifampin
  • Somatostatin
  • Yohimbine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma, severe or
  • Head injury, suspected or known or
  • Increased pressure in the head or
  • Paralytic ileus (intestine stops working and may be blocked) or
  • Respiratory depression (very slow breathing) or
  • Shock (serious condition with very little blood flow in the body)—Should not be used in patients with these conditions.
  • Breathing problems, severe (e.g., hypoxia, chronic obstructive pulmonary disease, COPD) or
  • Enlarged prostate (BPH, prostatic hypertrophy) or
  • Heart disease or
  • Problems with passing urine—Use with caution. May increase risk for more serious side effects.
  • Gallbladder disease or
  • Hypotension (low blood pressure) or
  • Sleep apnea syndrome (breathing problems during sleep) or
  • Pancreatitis (inflammation of the pancreas) or
  • Seizures, history of—Use with caution. May make these conditions worse.

Proper Use

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle or catheter in your back (epidural).

Precautions

It is important that your doctor check your progress after you receive this medicine. This is to make sure that the medicine is working properly, and to allow your doctor to check for any unwanted effects.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the medicines listed above after you receive this medicine.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Blurred vision
  2. confusion
  3. decrease in the frequency of urination
  4. decrease in urine volume
  5. difficulty in passing urine (dribbling)
  6. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  7. drowsiness
  8. fast, pounding, or irregular heartbeat or pulse
  9. painful urination
  10. pale skin
  11. shortness of breath
  12. sweating
  13. unusual tiredness or weakness

Less common

  1. Abdominal or stomach cramps or pain
  2. bloating
  3. constipation
  4. convulsions
  5. diarrhea
  6. difficult or labored breathing
  7. dry mouth
  8. increased thirst
  9. irregular, fast, slow, or shallow breathing
  10. loss of appetite
  11. mood changes
  12. muscle pain or cramps
  13. pale or blue lips, fingernails, or skin
  14. restlessness
  15. shakiness
  16. sleepiness
  17. slow to respond
  18. slurred speech
  19. tightness in the chest
  20. unconsciousness
  21. vomiting
  22. wheezing

Incidence not known

  1. Bluish lips or skin
  2. disorientation
  3. hallucinations
  4. lethargy
  5. low blood pressure or pulse
  6. severe drowsiness
  7. slowing of the heartbeat
  8. unresponsiveness
  9. very slow breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Bloated or full feeling
  2. excess air or gas in the stomach or intestines
  3. fever
  4. headache
  5. nausea
  6. passing gas
  7. skin itching
  8. sleeplessness
  9. trouble sleeping
  10. troubled breathing with exertion
  11. unable to sleep
  12. unusual bleeding or bruising

Less common

  1. Back pain
  2. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  3. chest pain or discomfort
  4. fear or nervousness
  5. feeling unusually cold
  6. lower abdominal or stomach pain or pressure
  7. pounding in the ears
  8. pressure in the stomach
  9. shivering
  10. slow or irregular heartbeat
  11. swelling of the abdominal or stomach area

Incidence not known

  1. Not alert
  2. trouble with coordination

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.