Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of methylprednisolone injection in children. However, pediatric patients are more likely to have slower growth and bone problems if methylprednisolone injection is used for a long time. Recommended doses should not be exceeded, and the patient should be carefully monitored during therapy.

Depo-Medrol® and some strengths of Solu-Medrol® injection should not be used in premature infants. Both brands of methylprednisolone injection contain benzyl alcohol, which may cause serious unwanted effects in premature infants.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methylprednisolone injection in the elderly. However, elderly patients are more likely to have liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving methylprednisolone injection.

Pregnancy

Information about this methylprednisolone-injection-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aldesleukin
  • Bupropion
  • Fluindione
  • Pixantrone
  • Telaprevir

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Alatrofloxacin
  • Alcuronium
  • Aprepitant
  • Aspirin
  • Atracurium
  • Balofloxacin
  • Carbamazepine
  • Cinoxacin
  • Ciprofloxacin
  • Clarithromycin
  • Clinafloxacin
  • Cyclosporine
  • Dalfopristin
  • Diltiazem
  • Enoxacin
  • Erythromycin
  • Fleroxacin
  • Fluindione
  • Flumequine
  • Gallamine
  • Gemifloxacin
  • Grepafloxacin
  • Hexafluorenium
  • Itraconazole
  • Ketoconazole
  • Levofloxacin
  • Licorice
  • Lomefloxacin
  • Metocurine
  • Mibefradil
  • Moxifloxacin
  • Nefazodone
  • Norfloxacin
  • Ofloxacin
  • Pefloxacin
  • Phenobarbital
  • Primidone
  • Prulifloxacin
  • Quinupristin
  • Rifampin
  • Rosoxacin
  • Rufloxacin
  • Saiboku-To
  • Sparfloxacin
  • Temafloxacin
  • Tosufloxacin
  • Troleandomycin
  • Trovafloxacin Mesylate
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Brain injury, traumatic or
  • Cerebral malaria or
  • Fungal infections, systemic or
  • Herpes simplex eye infection, active or
  • Idiopathic thrombocytopenic purpura (low platelet count)—Should not be given to patients with these conditions.
  • Cataracts or
  • Cirrhosis (liver problem) or
  • Congestive heart failure or
  • Cushing's syndrome (adrenal gland problem) or
  • Depression or
  • Diabetes or
  • Emotional problems or
  • Eye infection or
  • Glaucoma or
  • Heart attack, recent or
  • Heart disease or
  • Hyperglycemia (high blood sugar) or
  • Hypertension (high blood pressure) or
  • Mental illness or
  • Myasthenia gravis (severe muscle weakness) or
  • Osteoporosis (weak bones) or
  • Stomach or bowel problems (e.g., diverticulitis, ulcers, ulcerative colitis) or
  • Thyroid problems or
  • Tuberculosis, inactive—Use with caution. May make these conditions worse.
  • Infection (bacteria, virus, fungus, parasite, or protozoa)—May decrease your body's ability to fight infection.