Interactions

Interactions with Drugs

Lycopene may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Lycopene may cause low blood pressure. Caution is advised in people taking drugs that lower blood pressure.

Lycopene may interact with agents that bind to bile acid, agents that may affect the immune system, agents that may affect the nervous system, agents that may increase sensitivity to sunlight, agents that may treat lung disorders, agents that may treat stomach disorders, alcohol (ethanol), androgens, antiasthmatic agents, anticancer agents, anti-inflammatory agents, arsenic, cholesterol-lowering agents, creatine, fertility agents, HMG-CoA reductase inhibitors (statins), nicotine, and probucol.

Interactions with Herbs and Dietary Supplements

Lycopene may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Lycopene may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.

Lycopene may interact with androgenics, antiasthmatic herbs and supplements, anticancer herbs and supplements, anti-inflammatory herbs and supplements, antioxidants, astaxanthin, beta-carotene, canthaxanthin, carotenoids, cholesterol-lowering herbs and supplements, fertility herbs and supplements, herbs and supplements that may affect the immune system, herbs and supplements that may affect the nervous system, herbs and supplements that may increase sensitivity to sunlight, herbs and supplements that may treat lung disorders, herbs and supplements that may treat stomach disorders, isoflavones, lutein, palm oil, saw palmetto, tobacco or nicotine-containing herbs and supplements, vitamin C, vitamin D, and vitamin E.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com