Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Latuda

Descriptions


Lurasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia. This medicine should not be used to treat behavioral problems in elderly patients who have dementia.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of lurasidone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lurasidone in the elderly. However, this medicine should not be used for behavioral problems in older adults with dementia.

Pregnancy

Information about this lurasidone-oral-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Atazanavir
  • Boceprevir
  • Carbamazepine
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Enzalutamide
  • Fosphenytoin
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lopinavir
  • Metoclopramide
  • Nefazodone
  • Nelfinavir
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Saquinavir
  • St John's Wort
  • Telaprevir
  • Telithromycin
  • Tipranavir
  • Voriconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Amprenavir
  • Aprepitant
  • Ceritinib
  • Ciprofloxacin
  • Crizotinib
  • Darunavir
  • Delavirdine
  • Diltiazem
  • Erythromycin
  • Eslicarbazepine Acetate
  • Fluconazole
  • Fosamprenavir
  • Idelalisib
  • Imatinib
  • Mitotane
  • Piperaquine
  • Siltuximab
  • Verapamil

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alzheimer's disease or dementia or
  • Dehydration or
  • Heart attack, history of or
  • Heart failure or
  • Heart or blood vessel disease or
  • Heart rhythm problems or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low amount of blood) or
  • Stroke, history of or
  • Trouble swallowing—May cause side effects to become worse.
  • Blood or bone marrow problems (e.g., agranulocytosis, leukopenia, neutropenia) or
  • Diabetes, or risk factors for diabetes or
  • Dyslipidemia (high cholesterol or fats in the blood) or
  • Hyperglycemia (high blood sugar) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Kidney disease, moderate to severe or
  • Liver disease, moderate to severe—You may need a dose adjustment. Talk with your doctor if you have concerns about this.

Proper Use

Take this medicine only as directed by your doctor even if you feel well. Do not take more of this medicine and do not take it more often than your doctor ordered. This medicine works best if there is a constant amount in the blood. To keep blood levels constant, take this medicine at the same time each day and do not miss any doses.

You must take this medicine with food (containing at least 350 calories).

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For schizophrenia:
      • Adults—At first, 40 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 160 mg per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Lurasidone should not be used with ketoconazole (Nizoral®) or rifampin (Rifadin®, Rimactane®). Make sure your doctor knows what medications you are taking or if you start a new medicine.

Stop taking this medicine and check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs while you are using this medicine.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are using this medicine. Talk to your doctor about ways to prevent weight gain.

Lurasidone can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

This medicine may cause some people to become drowsy or dizzy, or to have trouble with thinking or controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert, well-coordinated, or able to think well.

Avoid activities involving high temperature or humidity. This medicine may reduce your body's ability to adjust to the heat.

Lurasidone may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies. If you or your caregiver notice any of these side effects, tell your doctor right away.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicines including other narcotics, medicine for seizures (e.g., barbiturates), muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Absence of or decrease in body movement
  2. difficulty with swallowing
  3. drooling
  4. inability to sit still
  5. incremental or ratchet-like movement of the muscle
  6. loss of balance control
  7. mask-like face
  8. muscle discomfort
  9. muscle trembling, jerking, or stiffness
  10. need to keep moving
  11. restlessness
  12. rigid or stiff muscles
  13. shakiness in the legs, arms, hands, or feet
  14. shuffling walk
  15. slow movements
  16. slow reflexes
  17. slurred speech
  18. stiffness of the arms and legs
  19. tic-like (jerky) movements of the head, face, mouth, and neck
  20. trembling or shaking of the hands or feet
  21. twisting movements of the body
  22. uncontrolled movements, especially of the face, neck, and back

Less common

  1. Arm, back, or jaw pain
  2. blurred vision
  3. burning while urinating
  4. changes in patterns and rhythms of speech
  5. chest pain or discomfort
  6. chills
  7. cold sweats
  8. confusion
  9. convulsions
  10. difficult or painful urination
  11. difficulty opening the mouth
  12. difficulty with breathing
  13. dizziness
  14. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  15. fast, pounding, or irregular heartbeat or pulse
  16. fixed position of the eye
  17. headache
  18. high fever
  19. inability to move the eyes
  20. inability to speak
  21. increased blinking or spasms of the eyelid
  22. increased sweating
  23. lockjaw
  24. loss of bladder control
  25. muscle spasm, especially of the neck and back
  26. nervousness
  27. pale skin
  28. pounding in the ears
  29. seizures
  30. severe muscle stiffness
  31. severe or sudden headache
  32. shortness of breath
  33. slow or fast heartbeat
  34. slurred speech
  35. sticking out of the tongue
  36. sweating
  37. temporary blindness
  38. tiredness
  39. trouble with breathing, speaking, or swallowing
  40. troubled breathing with exertion
  41. uncontrolled twisting movements of the neck, trunk, arms, or legs
  42. unusual bleeding or bruising
  43. unusual facial expressions
  44. unusual tiredness or weakness
  45. unusually pale skin
  46. weakness in the arm or leg on one side of the body, sudden and severe

Rare

  1. Black, tarry stools
  2. bloody urine
  3. breast pain or swelling
  4. cough
  5. dark-colored urine
  6. decreased frequency or amount of urine
  7. fever
  8. increased thirst
  9. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  10. loss of appetite
  11. lower back or side pain
  12. muscle cramps or spasms
  13. muscle pain or stiffness
  14. nausea
  15. sore throat
  16. sores, ulcers, or white spots on the lips or in the mouth
  17. swelling of the face, fingers, or lower legs
  18. swollen glands
  19. troubled breathing
  20. vomiting
  21. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. anxiety
  3. belching
  4. drowsiness
  5. dry mouth
  6. heartburn
  7. hyperventilation
  8. indigestion
  9. irritability
  10. relaxed and calm
  11. sleepiness or unusual drowsiness
  12. sleeplessness
  13. stomach discomfort, upset, or pain
  14. trouble sleeping
  15. unable to sleep
  16. unusually deep sleep
  17. unusually long duration of sleep

Less common

  1. Abnormal dreams
  2. anxiety
  3. back pain
  4. blurred vision
  5. burning feeling in the chest or stomach
  6. decreased appetite
  7. diarrhea
  8. feeling of constant movement of self or surroundings
  9. indigestion
  10. itching
  11. sensation of spinning
  12. skin rash
  13. sweating
  14. tenderness in the stomach area
  15. watering of mouth and drooling

Rare

  1. Decreased interest in sexual intercourse
  2. inability to have or keep an erection
  3. loss in sexual ability, desire, drive, or performance
  4. unexpected or excess milk flow from the breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.