Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Normodyne
  2. Trandate

Descriptions


Labetalol injection is used to treat severe high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .

This medicine is available only with your doctor's prescription .

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of labetalol injection in the pediatric population. Safety and efficacy have not been established .

Geriatric

No information is available on the relationship of age to the effects of labetalol in geriatric patients. However, elderly patients are more likely to have age-related liver and heart problems, which may require an adjustment in the dose for patients receiving labetalol injection .

Pregnancy

Information about this labetalol-intravenous-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Albuterol
  • Amiodarone
  • Arformoterol
  • Bambuterol
  • Clenbuterol
  • Colterol
  • Crizotinib
  • Diltiazem
  • Dronedarone
  • Fenoldopam
  • Fenoterol
  • Fingolimod
  • Formoterol
  • Halothane
  • Hexoprenaline
  • Indacaterol
  • Iobenguane I 123
  • Isoetharine
  • Levalbuterol
  • Metaproterenol
  • Olodaterol
  • Pirbuterol
  • Procaterol
  • Reproterol
  • Ritodrine
  • Salmeterol
  • Terbutaline
  • Tretoquinol
  • Tulobuterol
  • Verapamil
  • Vilanterol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetohexamide
  • Acetyldigoxin
  • Alfuzosin
  • Amlodipine
  • Amtolmetin Guacil
  • Arbutamine
  • Aspirin
  • Benfluorex
  • Bromfenac
  • Bufexamac
  • Bunazosin
  • Celecoxib
  • Chlorpropamide
  • Choline Salicylate
  • Cimetidine
  • Clonixin
  • Deslanoside
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitoxin
  • Digoxin
  • Dipyrone
  • Doxazosin
  • Enflurane
  • Epinephrine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Felodipine
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Guar Gum
  • Ibuprofen
  • Ibuprofen Lysine
  • Indomethacin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Iobenguane I 131
  • Isoflurane
  • Ketoprofen
  • Ketorolac
  • Lacidipine
  • Lercanidipine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Magnesium Sulfate
  • Manidipine
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metformin
  • Metildigoxin
  • Mibefradil
  • Miglitol
  • Morniflumate
  • Moxisylyte
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nicardipine
  • Nifedipine
  • Niflumic Acid
  • Nilvadipine
  • Nimesulide
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenoxybenzamine
  • Phentolamine
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranidipine
  • Pranoprofen
  • Prazosin
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Repaglinide
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • St John's Wort
  • Sulindac
  • Tamsulosin
  • Tenoxicam
  • Terazosin
  • Tiaprofenic Acid
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Trimazosin
  • Troglitazone
  • Urapidil
  • Valdecoxib

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (severe chest pain)—May provoke chest pain if stopped too quickly .
  • Asthma or
  • Bradycardia (slow heartbeat) or
  • Heart block or
  • Heart failure or
  • Low blood pressure, severe and prolonged—Should not use in patients with these conditions .
  • Diabetes or
  • Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body .
  • Lung disease (e.g., bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition .
  • Pheochromocytoma (adrenal gland tumor)—Use with caution. May require an increased dose .

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins .

Precautions

Your doctor will only give you a few doses of this medicine, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor .

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Dizziness
  2. tingling of the scalp or skin

Less common

  1. Abdominal or stomach pain
  2. black, tarry stools
  3. blurred vision
  4. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  5. chills
  6. clay-colored stools
  7. confusion
  8. dark urine
  9. diarrhea
  10. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  11. fast, pounding, or irregular heartbeat or pulse
  12. feeling of constant movement of self or surroundings
  13. fever
  14. general tiredness and weakness
  15. headache
  16. itching skin
  17. light-colored stools
  18. loss of appetite
  19. nausea and vomiting
  20. palpitations
  21. sensation of spinning
  22. skin rash
  23. sweating
  24. unpleasant breath odor
  25. unusual tiredness or weakness
  26. vomiting of blood
  27. wheezing
  28. yellow eyes or skin

Rare

  1. Chest pain or discomfort
  2. cough
  3. difficult or labored breathing
  4. difficulty swallowing
  5. hives or welts
  6. hoarseness
  7. irritation
  8. joint pain, stiffness, or swelling
  9. large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  10. lightheadedness, dizziness, or fainting
  11. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  12. redness of skin
  13. shortness of breath
  14. slow heartbeat
  15. swelling of eyelids, face, lips, hands, or feet
  16. tightness in chest
  17. troubled breathing or swallowing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Convulsions
  2. dilated neck veins
  3. extreme fatigue
  4. irregular breathing
  5. loss of bladder control
  6. muscle spasm or jerking of all extremities
  7. noisy breathing
  8. sudden loss of consciousness
  9. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Stuffy nose

Less common

  1. Acid or sour stomach
  2. belching
  3. change in taste or bad, unusual, or unpleasant (after) taste
  4. decreased interest in sexual intercourse
  5. heartburn
  6. inability to have or keep an erection
  7. increased yawning
  8. indigestion
  9. loss in sexual ability, desire, drive, or performance
  10. sleepiness or unusual drowsiness
  11. stomach discomfort or upset
  12. vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.