Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Haldol
  2. Haldol Decanoate

Descriptions


Haloperidol injection is used to treat nervous, emotional, and mental conditions (e.g., schizophrenia). It is also used to control the symptoms of Tourette's disorder. This medicine should not be used to treat behavior problems in older adult patients who have dementia.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Solution
  • Suspension
  • Oil

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of haloperidol injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of haloperidol injection in the elderly. However, elderly women are more likely to have a side effect called tardive dyskinesia, and elderly patients are more likely to have age-related heart problems, which may require an adjustment in the dose for patients receiving haloperidol injection.

Pregnancy

Information about this haloperidol-intramuscular-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Bepridil
  • Cisapride
  • Dronedarone
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Sparfloxacin
  • Terfenadine
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Alfuzosin
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Apomorphine
  • Aprindine
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bedaquiline
  • Bretylium
  • Bupropion
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Cobicistat
  • Crizotinib
  • Dabrafenib
  • Dalfopristin
  • Dasatinib
  • Desipramine
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxepin
  • Droperidol
  • Encainide
  • Enflurane
  • Erythromycin
  • Eslicarbazepine Acetate
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Formoterol
  • Foscarnet
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Hydromorphone
  • Hydroquinidine
  • Ibutilide
  • Imipramine
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Levofloxacin
  • Lithium
  • Lopinavir
  • Lorcainide
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Mifepristone
  • Milnacipran
  • Moxifloxacin
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Paliperidone
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Pixantrone
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propranolol
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Quinupristin
  • Ranolazine
  • Risperidone
  • Salmeterol
  • Saquinavir
  • Sematilide
  • Sertindole
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Tizanidine
  • Toremifene
  • Tramadol
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Ziprasidone
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Benztropine
  • Betel Nut
  • Buspirone
  • Carbamazepine
  • Dextromethorphan
  • Fluvoxamine
  • Methyldopa
  • Nefazodone
  • Olanzapine
  • Procyclidine
  • Rifampin
  • Rifapentine
  • Tacrine
  • Trihexyphenidyl

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Breast cancer, prolactin-dependent, history of or
  • Chest pain or
  • Heart or blood vessel disease, severe or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Hypotension (low blood pressure) or
  • Mania or
  • Neuroleptic malignant syndrome, history of or
  • Seizures or epilepsy, history of—Use with caution. May make these conditions worse.
  • Central nervous system depression, severe or
  • Coma or
  • Dementia in the elderly or
  • Parkinson's disease—Should not be used in patients with these conditions.
  • Heart rhythm problems (e.g., familial long QT-syndrome), history of or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypothyroidism (underactive thyroid) or
  • Lung disease (e.g., bronchopneumonia) or
  • Thyrotoxicosis (overactive thyroid)—May increase risk for more serious side effects.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles.

Your doctor may give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions

It is very important that your doctor check your progress while you receive this medicine to allow for changes in your dose and help reduce any unwanted effects.

Contact your doctor as soon as possible if you have chest pain or discomfort, a fast heartbeat, trouble with breathing, or fever and chills. These may be symptoms of a very serious problem with your heart.

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while using this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Check with your doctor right away if you have any of the following symptoms while receiving this medicine: convulsions (seizures); difficulty with breathing; a fast heartbeat; a high fever; high or low blood pressure; increased sweating; loss of bladder control; severe muscle stiffness; unusually pale skin; or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine will often make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are using this medicine, since overheating may result in heat stroke. Also, hot baths or saunas may make you feel dizzy or faint while you are using this medicine.

This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Haloperidol injection can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  1. Abdominal or stomach pain
  2. anxiety
  3. black, tarry stools
  4. bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at injection site
  5. blurred vision
  6. chest pain
  7. chills
  8. clay-colored stools
  9. cold sweats
  10. coma
  11. confusion
  12. continuing nausea or vomiting
  13. convulsions
  14. cool, pale skin
  15. cough or hoarseness
  16. dark urine
  17. decrease in frequency of urination
  18. decrease in urine volume
  19. decreased urine output
  20. depression
  21. difficulty in passing urine (dribbling)
  22. difficulty with breathing
  23. difficulty with speaking
  24. dizziness
  25. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  26. drooling
  27. dry mouth
  28. eye pain
  29. fainting
  30. false or unusual sense of well-being
  31. fast, pounding, or irregular heartbeat or pulse
  32. fever
  33. fever with or without chills
  34. flushed, dry skin
  35. fruit-like breath odor
  36. general feeling of illness
  37. general feeling of tiredness or weakness
  38. headache
  39. high fever
  40. high or low blood pressure
  41. hot, dry skin
  42. hyperventilation
  43. inability to move the eyes
  44. inability to sit still
  45. increase in the frequency of seizures
  46. increased blinking or spasms of the eyelid
  47. increased hunger
  48. increased sweating
  49. increased thirst
  50. increased urination
  51. irregular heartbeat recurrent
  52. irritability
  53. itching
  54. lack of sweating
  55. lip smacking or puckering
  56. loss of appetite
  57. loss of bladder control
  58. loss of consciousness
  59. lower back or side pain
  60. muscle weakness
  61. muscle pain or cramps
  62. muscle trembling, jerking, or stiffness
  63. nausea or vomiting
  64. need to keep moving
  65. nervousness
  66. nightmares
  67. noisy breathing
  68. painful or difficult urination
  69. pale skin
  70. pounding in the ears
  71. puffing of the cheeks
  72. rapid or worm-like movements of the tongue
  73. rash
  74. restlessness
  75. seizures
  76. severe muscle stiffness
  77. shakiness
  78. shaking
  79. shortness of breath
  80. shuffling walk
  81. slurred speech
  82. sore throat
  83. sores, ulcers, or white spots on the lips or in the mouth
  84. sticking out of the tongue
  85. stiffness of the limbs
  86. sweating
  87. swelling of the face, ankles, or hands
  88. swollen glands
  89. tightness in the chest
  90. tiredness and weakness
  91. total body jerking
  92. trouble with breathing, speaking, or swallowing
  93. trouble with sleeping
  94. troubled breathing with exertion
  95. twisting movements of the body
  96. uncontrolled chewing movements
  97. uncontrolled twisting movements of the face, neck, trunk, arms, or legs
  98. unexplained weight loss
  99. unpleasant breath odor
  100. unusual bleeding or bruising
  101. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  102. unusual facial expressions
  103. unusual tiredness or weakness
  104. unusually pale skin
  105. vomiting
  106. vomiting of blood
  107. weakness of the arms and legs
  108. wheezing
  109. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Acid or sour stomach
  2. acne or pimples
  3. belching
  4. blindness
  5. blurred vision or any other change in vision
  6. decreased interest in sexual intercourse
  7. decreased vision
  8. difficulty having a bowel movement (stool)
  9. disturbed color perception
  10. double vision
  11. drowsiness
  12. feeling of constant movement of self or surroundings
  13. fullness or swelling of the breasts
  14. halos around lights
  15. heartburn
  16. inability to have or keep an erection
  17. increased in sexual ability, desire, drive, or performance
  18. increased interest in sexual intercourse
  19. increased sensitivity of the skin to sunlight
  20. increased watering of the mouth
  21. indigestion
  22. loss in sexual ability, desire, drive, or performance
  23. loss of hair
  24. menstrual changes
  25. night blindness
  26. overbright appearance of lights
  27. pain or tenderness of the breasts
  28. painful or prolonged erection of the penis
  29. redness or other discoloration of the skin
  30. sensation of spinning
  31. severe sunburn
  32. sleeplessness
  33. stomach discomfort, upset, or pain
  34. swelling of the breasts or breast soreness in both females and males
  35. tunnel vision
  36. unable to sleep
  37. unusual secretion of milk
  38. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.