Description and Brand Names

Drug information provided by: Micromedex

Descriptions


Guanidine is used to treat muscle weakness and tiredness caused by the Eaton-Lambert syndrome. The Eaton-Lambert syndrome is an autoimmune disorder that affects the nervous system. Guanidine works on the nervous system to restore muscle strength.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of guanidine in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of guanidine in geriatric patients.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia (low red blood cells) or
  • Kidney disease or
  • Leukopenia (low white blood cells) or
  • Mood changes, history of or
  • Thrombocytopenia (low platelets in the blood)—Use with caution. May make these conditions worse.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For Eaton-Lambert syndrome:
      • Adults—Dose is based on body weight and must be determined by your doctor. The starting dose is usually between 10 and 15 milligrams (mg) per kilogram (kg) of body weight per day and divided in 3 or 4 doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 35 mg/kg/day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  1. Ammonia-like breath odor
  2. black, tarry stools
  3. bleeding gums
  4. blood in the urine or stools
  5. blurred vision
  6. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  7. change in frequency or amount of urine
  8. chest pain
  9. chills
  10. cloudy urine
  11. cold sensations in the hands and feet
  12. confusion
  13. cough
  14. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  15. fast, irregular, pounding, or racing heartbeat or pulse
  16. fever
  17. increased thirst
  18. loss of appetite
  19. nausea or vomiting
  20. painful or difficult urination
  21. pale skin
  22. pinpoint red spots on the skin
  23. shakiness in the legs, arms, hands, or feet
  24. shortness of breath, especially with exercise
  25. sore throat
  26. sores, ulcers, or white spots on the lips or in the mouth
  27. sweating
  28. swollen glands
  29. unsteadiness, trembling, or problems with muscle control
  30. unusual bleeding or bruising
  31. unusual tiredness or weakness
  32. weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Abdominal or stomach cramps
  2. burning, itching, and pain in hairy areas
  3. crying for no reason
  4. dry mouth
  5. dryness and scaling of the skin
  6. false or unusual sense of well-being
  7. feeling irritated
  8. feeling of warmth
  9. feeling paranoid
  10. jitteriness
  11. large, flat, blue or purplish patches in the skin
  12. mood or mental changes
  13. pinpoint red or purple spots on the skin
  14. quick to react or overreact emotionally
  15. rash
  16. redness of the face, neck, arms, and occasionally, upper chest
  17. restlessness
  18. seeing or hearing things that are not there

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.