Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Multihance

Descriptions


Gadobenate is a magnetic resonance imaging (MRI) contrast agent. Contrast agents are used to help create a clear picture of the body during MRI scans. MRI scans are a special kind of diagnostic procedure. They use magnets and computers to create images or “pictures” of certain areas inside the body. Unlike x-rays, they do not involve ionizing radiation. Gadobenate is a gadolinium-based contrast agent (GBCA).

Gadobenate is given by injection before MRI to help diagnose problems in the brain, spine, and other parts of your body.

This medicine is to be used only by or under the direct supervision of a doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of gadobenate solution in children 2 years of age and older. However, safety and efficacy have not been established in children younger than 2 years of age.

Appropriate studies have not been performed on the relationship of age to the effects of gadobenate Multipack™ in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of gadobenate in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving gadobenate.

Pregnancy

Information about this gadobenate-intravenous-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or any other blood disorder or
  • Asthma or allergies, history of or
  • Heart disease, history of or
  • Heart rhythm problems (e.g., arrhythmia) or
  • Kidney problems, severe (recent or long-term) or
  • Liver disease or
  • Patients who have recently received a GBCA or
  • Seizures, history of—Use with caution. May cause side effects to become worse.
  • Diabetes or
  • Hypertension (high blood pressure)—Use with caution. May increase risk for more serious side effects.
  • Dubin-Johnson syndrome (an inherited disorder)—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins just before you have an MRI scan.

Precautions

It is very important that your doctor check the progress of you or your child while you are receiving this medicine and during the MRI scan. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects.

Check with your doctor right away if you or your child have burning or itching of the skin; red or dark patches on the skin; skin swelling, hardening, or tightening; joint stiffness; limited range of motion in the arms and legs; pain that is deep in the hip bone or ribs; or muscle weakness. These may be symptoms of a very serious disease called nephrogenic systemic fibrosis (NSF).

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Check with your doctor or nurse right away if you or your child have cold, clammy skin; confusion; dizziness; lightheadedness; a skin rash; itching; sweating; swelling of the face, tongue, and throat; trouble with breathing; or chest pain after you receive the medicine.

Tell your doctor right away if you or your child have mild, burning pain; feeling of warmth or coldness; redness or swelling at the injection site.

This medicine can cause changes in the heart rhythm, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you or your child have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Before you have any medical tests, tell the medical doctor in charge that you or your child are using gadobenate. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

  1. Abdominal or stomach pain
  2. anxiety
  3. back pain
  4. black, tarry stools
  5. bladder pain
  6. bloody or cloudy urine
  7. blue lips and fingernails
  8. blurred vision
  9. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  10. chest pain or discomfort
  11. chills
  12. confusion
  13. convulsions
  14. cough
  15. coughing that sometimes produces a pink frothy sputum
  16. dark urine
  17. decreased urination
  18. deep or fast breathing with dizziness
  19. difficult or labored breathing
  20. difficult, burning, or painful urination
  21. difficult, fast, or noisy breathing, sometimes with wheezing
  22. difficulty with breathing or swallowing
  23. dizziness
  24. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  25. excessive muscle tone
  26. fainting
  27. fast, slow, or irregular heartbeat
  28. fever
  29. frequent urge to urinate
  30. general feeling of discomfort or illness
  31. headache
  32. hives
  33. inability to move the legs or arms
  34. increased sweating
  35. itching
  36. lightheadedness, dizziness, or fainting
  37. lower back or side pain
  38. muscle stiffness
  39. muscle tension or tightness
  40. nausea
  41. nervousness
  42. numbness of the feet, hands, and around the mouth
  43. pain in the shoulders, arms, jaw, or neck
  44. pain or redness at the injection site
  45. pale skin
  46. pale skin at the injection site
  47. paralysis of one side of the body
  48. pounding heartbeat
  49. pounding in the ears
  50. problems with speech or speaking
  51. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  52. reddening of the skin, especially around the ears
  53. shakiness in the legs, arms, hands, or feet
  54. shortness of breath
  55. skin rash
  56. sore throat
  57. sores, ulcers, or white spots on the lips or in the mouth
  58. sudden shortness of breath or troubled breathing
  59. sugar in the urine
  60. sweating
  61. swelling in the legs and ankles
  62. swelling of the eyes, face, or inside of the nose
  63. swollen glands
  64. tightness in the chest
  65. tiredness
  66. trembling or shaking of the hands or feet
  67. unusual bleeding or bruising
  68. unusual tiredness or weakness
  69. wheezing
  70. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  2. feeling hot

Rare

  1. Acid or sour stomach
  2. bad, unusual, or unpleasant (after) taste
  3. belching
  4. blurred or loss of vision
  5. change in sense of smell
  6. change in taste
  7. continuing ringing or buzzing or other unexplained noise in the ears
  8. decreased awareness or responsiveness
  9. diarrhea
  10. difficulty having a bowel movement (stool)
  11. difficulty with moving
  12. disturbed color perception
  13. double vision
  14. dry mouth
  15. ear pain
  16. feeling unusually cold
  17. halos around lights
  18. hearing loss
  19. heartburn
  20. hives or welts
  21. indigestion
  22. joint pain
  23. lack or loss of strength
  24. loss of bowel control
  25. muscle aches or cramps
  26. muscle spasms
  27. night blindness
  28. overbright appearance of lights
  29. redness of the eye
  30. redness of the skin
  31. severe sleepiness
  32. shivering
  33. stomach discomfort, upset, or pain
  34. stuffy nose
  35. swelling of the eyelid
  36. swollen joints
  37. tunnel vision
  38. vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.