Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Teveten HCT

Descriptions


Eprosartan and hydrochlorothiazide combination is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.

Eprosartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes the blood vessels to tighten. As a result, eprosartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.

Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of eprosartan and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of eprosartan and hydrochlorothiazide combination in the elderly.

Pregnancy

Information about this eprosartan-and-hydrochlorothiazide-oral-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Aliskiren
  • Dofetilide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Arsenic Trioxide
  • Benazepril
  • Captopril
  • Cyclophosphamide
  • Deslanoside
  • Digitalis
  • Digitoxin
  • Digoxin
  • Droperidol
  • Enalapril
  • Enalaprilat
  • Flecainide
  • Fosinopril
  • Ketanserin
  • Levomethadyl
  • Lisinopril
  • Lithium
  • Methotrexate
  • Metildigoxin
  • Moexipril
  • Ouabain
  • Perindopril Erbumine
  • Proscillaridin
  • Quinapril
  • Ramipril
  • Sotalol
  • Trandolapril

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Amtolmetin Guacil
  • Aspirin
  • Benazepril
  • Bepridil
  • Bromfenac
  • Bufexamac
  • Captopril
  • Carbamazepine
  • Celecoxib
  • Chlorpropamide
  • Cholestyramine
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Delapril
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Enalaprilat
  • Enalapril Maleate
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Ginkgo
  • Glipizide
  • Gossypol
  • Ibuprofen
  • Ibuprofen Lysine
  • Imidapril
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranoprofen
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Ramipril
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Spirapril
  • Sulindac
  • Temocapril
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Trandolapril
  • Valdecoxib
  • Zofenopril

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anuria (not able to pass urine) or
  • Diabetic patients who are also taking aliskiren (Tekturna®) or
  • Sulfa drug allergy (e.g., sulfamethoxazole, sulfasalazine, sulfisoxazole, Azulfidine®, Bactrim®, Septra®)—Should not be used in these patients.
  • Asthma, history of—May increase likelihood of having an allergic reaction.
  • Congestive heart failure, severe—Use may lead to kidney problems.
  • Diabetes or
  • Electrolyte imbalances (e.g., high or low potassium, magnesium, or sodium in the body) or
  • Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or
  • Glaucoma, secondary angle closure or
  • Gout or
  • Hypercalcemia (high calcium in the blood) or
  • Kidney problems or
  • Liver disease or
  • Myopia, acute (changes in the eyeball causing vision problems) or
  • Systemic lupus erythematosus (an autoimmune disorder)—Use with caution. May make these conditions worse.

Proper Use

This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

You may take this medicine with or without food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For high blood pressure:
      • Adults—One tablet once a day. Your doctor may increase your dose as needed.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up from a lying or sitting position or if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, stop using this medicine and call your doctor right away.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt which may cause low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Check with your doctor immediately if blurred vision, difficulty reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor may want an eye doctor to check your eyes.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium without first checking with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

  1. Abdominal or stomach pain
  2. ankle, knee, or great toe joint pain
  3. arm, back, or jaw pain
  4. bladder pain
  5. bloating or swelling of the face, arms, hands, lower legs, or feet
  6. bloody or cloudy urine
  7. blurred vision
  8. chest pain or discomfort
  9. chest tightness or heaviness
  10. confusion
  11. convulsions
  12. decreased urine output
  13. difficulty breathing
  14. difficult, burning, or painful urination
  15. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  16. dry mouth
  17. fast, pounding, or irregular heartbeat or pulse
  18. feeling of warmth
  19. fever
  20. flushed or dry skin
  21. frequent urination
  22. fruit-like breath odor
  23. headache
  24. increased hunger
  25. increased thirst
  26. increased volume of pale, dilute urine
  27. itching of the skin
  28. joint stiffness or swelling
  29. loss of appetite
  30. loss of bladder control
  31. loss of consciousness
  32. lower back or side pain
  33. muscle pain or cramps
  34. nausea or vomiting
  35. nervousness
  36. numbness and tingling of the face, fingers, or toes
  37. pale, bluish-colored, or cold hands or feet
  38. pinpoint red or purple spots on the skin
  39. rapid weight gain
  40. sudden decrease in the amount of urine
  41. sudden sweating
  42. unexplained weight loss
  43. unusual bleeding or bruising
  44. unusual tiredness or weakness
  45. unusual weight gain or loss
  46. weakness or heaviness of the legs

Incidence not known

  1. Back, leg, or stomach pains
  2. black, tarry stools
  3. bleeding gums
  4. blistering, peeling, or loosening of the skin
  5. bloody or cloudy urine
  6. chills
  7. constipation
  8. cough or hoarseness
  9. coughing up blood
  10. darkened urine
  11. decreased frequency or amount of urine
  12. diarrhea
  13. difficulty with swallowing
  14. drowsiness
  15. fever with or without chills
  16. general body swelling
  17. general feeling of tiredness or weakness
  18. hives
  19. indigestion
  20. irritability
  21. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  22. nosebleeds
  23. pains in the stomach, side, or abdomen, possibly radiating to the back
  24. pale skin
  25. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  26. red skin lesions, often with a purple center
  27. red, irritated eyes
  28. skin rash
  29. sore throat
  30. sores, ulcers, or white spots on the lips or in the mouth
  31. swollen or painful glands
  32. thickening of bronchial secretions
  33. unusual weight loss
  34. vision changes
  35. weak pulse
  36. weight gain
  37. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  1. Acid or sour stomach
  2. belching
  3. body aches or pain
  4. bone pain
  5. burning feeling in the chest or stomach
  6. burning or stinging of the skin
  7. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  8. burning, dry, or itching eyes
  9. change in hearing
  10. cold or flu-like symptoms
  11. congestion
  12. continuing ringing or buzzing or other unexplained noise in the ears
  13. cough producing mucus
  14. depression
  15. difficulty moving
  16. ear drainage
  17. earache
  18. excess air or gas in the stomach or intestines
  19. fear or nervousness
  20. feeling of constant movement of self or surroundings
  21. feeling unusually cold
  22. full feeling
  23. headache, severe and throbbing
  24. hearing loss
  25. heartburn
  26. increased sweating
  27. irritation in the mouth
  28. itching ears
  29. lack or loss of strength
  30. loose teeth
  31. loss of voice
  32. multiple swollen and inflamed skin lesions
  33. muscle stiffness
  34. pain, inflammation, or swelling in the calves, shoulders, or hands
  35. painful cold sores or blisters on the lips, nose, eyes, or genitals
  36. passing gas
  37. persistent breath odor or bad taste in your mouth
  38. rash with flat lesions or small raised lesions on the skin
  39. redness and swelling of the gums
  40. redness or swelling of the ears
  41. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  42. runny or stuffy nose
  43. sensation of spinning
  44. shakiness in the legs, arms, hands, or feet
  45. shivering
  46. skin rash, encrusted, scaly, and oozing
  47. sleepiness or unusual drowsiness
  48. sneezing
  49. tender, swollen glands in the neck
  50. tenderness in the stomach area
  51. toothache
  52. trembling or shaking of the hands or feet
  53. trouble sleeping
  54. voice changes
  55. weight loss

Incidence not known

  1. Decreased interest in sexual intercourse
  2. hair loss or thinning of the hair
  3. hives or welts
  4. inability to have or keep an erection
  5. increased sensitivity of the skin to sunlight
  6. loss in sexual ability, desire, drive, or performance
  7. muscle spasm
  8. redness of the skin
  9. redness or other discoloration of the skin
  10. severe sunburn
  11. tenderness of the salivary glands

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.