Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Anzemet

Descriptions


Dolasetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation. Dolasetron works to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of dolasetron in children 2 years of age and older. However, safety and efficacy have not been established in children younger than 2 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dolasetron in the elderly. However, elderly patients are more likely to have heart rhythm problems, which may require caution in patients receiving dolasetron.

Pregnancy

Information about this dolasetron-oral-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Apomorphine
  • Bepridil
  • Cisapride
  • Dronedarone
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Sparfloxacin
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Alfuzosin
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Aprindine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bretylium
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Desipramine
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Domperidone
  • Doxepin
  • Droperidol
  • Enflurane
  • Erythromycin
  • Escitalopram
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Levofloxacin
  • Lidoflazine
  • Lopinavir
  • Lorcainide
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Mifepristone
  • Moxifloxacin
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Paliperidone
  • Pazopanib
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Pirmenol
  • Posaconazole
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Risperidone
  • Salmeterol
  • Saquinavir
  • Sematilide
  • Sertindole
  • Sevoflurane
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sultopride
  • Sunitinib
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Toremifene
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Zolmitriptan
  • Zotepine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Atrial fibrillation (abnormal heart rhythm) or
  • Bradycardia (slow heartbeat) or
  • Congestive heart failure or
  • Heart disease or
  • Heart rhythm problems, history of or
  • Kidney disease or
  • Sick sinus syndrome (abnormal heart rhythm), history of—Use with caution. May cause side effects to become worse.
  • Congenital long QT syndrome (abnormal heart rhythm) or
  • Heart block, without a pacemaker—Should not be used in patients with these conditions.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

If your child cannot swallow the tablets, the injection solution can be mixed with apple or apple-grape juice and taken by mouth. The mixture may be stored for up to 2 hours at room temperature before use.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For prevention of nausea and vomiting after cancer medicines:
      • Adults—100 milligrams (mg) given within 1 hour before starting cancer treatment.
      • Children 2 to 16 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 1.8 milligrams (mg) per kilogram (kg) of body weight given within 1 hour before starting cancer treatment. However, the dose is usually not more than 100 mg.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

This medicine can cause changes to your heart rhythm. It may cause fainting or serious side effects in some patients. Contact your doctor right away if you have a fast, pounding, or irregular heartbeat.

Do not stop taking this medicine without checking first with your doctor. Your doctor may gradually reduce the amount you are using before stopping completely.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Chest pain or discomfort
  2. lightheadedness, dizziness, or fainting
  3. shortness of breath
  4. slow or irregular heartbeat
  5. unusual tiredness or weakness

Less common

  1. Chills
  2. decrease in the amount of urine
  3. fast, pounding, or irregular heartbeat or pulse
  4. fever

Rare

  1. Agitation
  2. black, tarry stools
  3. bleeding gums
  4. bloating or swelling of the face, arms, hands, lower legs, or feet
  5. blood in the urine or stools
  6. blurred vision
  7. burning while urinating
  8. changes in skin color
  9. confusion
  10. cough
  11. depression
  12. difficult or labored breathing
  13. difficult or painful urination
  14. difficulty with swallowing
  15. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  16. frequent urination
  17. headache
  18. hives or welts
  19. increased volume of pale, dilute urine
  20. irritability
  21. itching of the skin
  22. lethargy
  23. low blood pressure
  24. muscle twitching
  25. nausea
  26. noisy breathing
  27. numbness and tingling of the face, fingers, or toes
  28. pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
  29. pain, tenderness, or swelling of the foot or leg
  30. pale skin
  31. pale, bluish-colored, or cold hands or feet
  32. pinpoint red or purple spots on the skin
  33. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  34. rapid weight gain
  35. red skin
  36. seizures
  37. skin rash
  38. sweating
  39. swelling of the face, ankles, or hands
  40. tightness in the chest
  41. tingling of the hands or feet
  42. troubled breathing with exertion
  43. unusual bleeding or bruising
  44. unusual weight gain or loss
  45. weak or absent pulses in the legs
  46. wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Diarrhea

Less common

  1. Acid or sour stomach
  2. belching
  3. heartburn
  4. indigestion
  5. pain
  6. stomach discomfort, upset, or pain

Rare

  1. Abnormal dreams
  2. agitation
  3. bad, unusual, or unpleasant (after) taste
  4. bloating
  5. bloody nose
  6. change in color vision
  7. change in taste
  8. changes in vision
  9. continuing ringing or buzzing or other unexplained noise in the ears
  10. darkened urine
  11. difficulty having a bowel movement (stool)
  12. difficulty seeing at night
  13. difficulty with moving
  14. feeling of constant movement of self or surroundings
  15. feeling of unreality
  16. feeling of warmth
  17. hearing loss
  18. increased sensitivity of the eyes to sunlight
  19. increased sweating
  20. joint pain
  21. loss of appetite
  22. muscle aching or cramping
  23. muscle pain or stiffness
  24. pain or burning sensation at the injection site
  25. pains in the stomach, side, or abdomen, possibly radiating to the back
  26. redness of the face, neck, arms, and occasionally, upper chest
  27. sensation of spinning
  28. sense of detachment from self or body
  29. shakiness and unsteady walk
  30. shakiness in the legs, arms, hands, or feet
  31. swollen joints
  32. trembling or shaking of the hands or feet
  33. unsteadiness, trembling, or other problems with muscle control or coordination
  34. vomiting
  35. weight loss
  36. yellow eyes or skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.