Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of unwanted effects.

Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all of the risks and benefits. It is important for you to work closely with your doctor during your treatment.

This medicine comes with a patient information leaflet. Follow the instructions carefully. Ask your doctor if you have any questions.

You may take this medicine with or without food. Swallow the tablet whole. Do not break, cut, crush, or chew it.

Pregnant women should avoid handling crushed or broken tablets. If a tablet is broken or crushed, wear disposable gloves to avoid exposure to the medicine.

If you are taking an antacid (eg, aluminum hydroxide, magnesium hydroxide, Maalox®, Rolaids®, or Tums®), take it at least 2 hours before or after you take dasatinib.

Do not drink grapefruit juice while you are using this medicine. Grapefruit juice may change the amount of medicine that is absorbed in the body.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For the treatment of chronic phase CML:
      • Adults—At first, 100 milligrams (mg) once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
      • Children 1 year of age and older—Dose is based on body weight and must be determined by your doctor.
        • Weighs 45 kilograms (kg) or more—At first, 100 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
        • Weighs 30 kg to less than 45 kg—At first, 70 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
        • Weighs 20 kg to less than 30 kg—At first, 60 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
        • Weighs 10 kg to less than 20 kg—At first, 40 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
      • Children younger than 1 year of age and weigh less than 10 kg—Use is not recommended.
    • For the treatment of accelerated or blast crisis CML or Ph+ ALL:
      • Adults—At first, 140 milligrams (mg) once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
      • Children 1 year of age and older—Dose is based on body weight and must be determined by your doctor.
        • Weighs 45 kilograms (kg) or more—At first, 100 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
        • Weighs 30 kg to less than 45 kg—At first, 70 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
        • Weighs 20 kg to less than 30 kg—At first, 60 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
        • Weighs 10 kg to less than 20 kg—At first, 40 mg once a day, given either in the morning or in the evening. Your doctor may adjust your dose as needed.
      • Children younger than 1 year of age and weigh less than 10 kg—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.