Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Cubicin

Descriptions


Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream, including right-sided infective endocarditis.

Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of daptomycin injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of daptomycin injection in the elderly. However, elderly patients are more likely to have increased unwanted side effects, which may require caution in patients receiving daptomycin injection.

Pregnancy

Information about this daptomycin-intravenous-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • Pravastatin
  • Rosuvastatin
  • Simvastatin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diarrhea or
  • Muscle problems or
  • Nerve problems (e.g., neuropathy)—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Staphylococcus infection, persisting or relapsing—Patients with this condition should have repeated blood tests.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. This medicine is given slowly, so the needle will remain in place for about 30 minutes.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Also, this medicine works best when there is a constant amount in the blood. To help keep the amount constant, you must receive this medicine on a regular schedule.

Precautions

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Call your doctor right away if you develop chest pain, dry cough, fever, general feeling of tiredness or weakness, rapid breathing, shortness of breath, skin rash, or wheezing after receiving this medicine. These maybe symptoms of a serious condition called eosinophilic pneumonia.

Daptomycin injection may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

If you have unexplained muscle pain, tenderness, or weakness while receiving this medicine, check with your doctor right away.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet after receiving this medicine. These could be symptoms of a condition called peripheral neuropathy.

Before you have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Bloating or swelling of the face, arms, hands, lower legs, or feet
  2. fever
  3. rapid weight gain
  4. tingling of the hands or feet
  5. unusual weight gain or loss

Less common

  1. Abdominal or stomach pain
  2. agitation
  3. black, tarry stools
  4. bladder pain
  5. bloody or cloudy urine
  6. blurred vision
  7. chest pain or discomfort
  8. chills
  9. coma
  10. confusion
  11. convulsions
  12. cough
  13. decreased frequency or amount of urine
  14. decreased urine output
  15. depression
  16. diarrhea
  17. difficult or labored breathing
  18. difficult, burning, or painful urination
  19. dilated neck veins
  20. dizziness
  21. dry mouth
  22. extreme fatigue
  23. fainting
  24. faintness or lightheadedness when getting up suddenly from a lying or sitting position
  25. fast heartbeat
  26. frequent urge to urinate
  27. headache
  28. hostility
  29. increased blood pressure
  30. increased thirst
  31. irregular breathing
  32. irregular heartbeat
  33. irritability
  34. itching in the genital or other skin areas
  35. itching, pain, redness, swelling, tenderness, or warmth on the skin
  36. lethargy
  37. lightheadedness
  38. loss of appetite
  39. lower back or side pain
  40. mood changes
  41. muscle pain or cramps
  42. muscle twitching
  43. nausea
  44. nervousness
  45. numbness or tingling in the hands, feet, or lips
  46. pale skin
  47. pounding in the ears
  48. rapid weight gain
  49. rapid, shallow breathing
  50. scaling
  51. seizures
  52. shortness of breath
  53. slow or fast heartbeat
  54. sneezing
  55. sore throat
  56. stupor
  57. sweating
  58. swelling of the face, fingers, ankles, or hands
  59. tightness in the chest
  60. troubled breathing with exertion
  61. unusual bleeding or bruising
  62. usual tiredness or weakness
  63. vomiting of blood or material that looks like coffee grounds
  64. weight gain
  65. wheezing

Rare

  1. Bleeding gums
  2. blood in the urine or stools
  3. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  4. clay-colored stools
  5. dark urine
  6. difficulty with moving
  7. drowsiness
  8. eye pain
  9. feeling of warmth
  10. feeling unusually cold
  11. general feeling of illness
  12. headache
  13. hives
  14. hoarseness
  15. increase in bone pain
  16. irritation
  17. itching
  18. joint pain, stiffness, or swelling
  19. loss of appetite
  20. mood or mental changes
  21. muscle aching or cramping
  22. muscle spasms (tetany) or twitching
  23. no blood pressure or pulse
  24. pain in the joints
  25. pinpoint red spots on the skin
  26. rapid or irregular heartbeat
  27. rash
  28. redness of the face, neck, arms, and occasionally, upper chest
  29. redness of the skin
  30. redness, blistering, peeling, or loosening of the skin
  31. shivering
  32. skin rash, encrusted, scaly and oozing
  33. sore throat
  34. sores, ulcers, or white spots on the lips or in the mouth
  35. stopping of heart
  36. swelling of the eyelids, face, lips, hands, or feet
  37. swollen glands
  38. swollen joints
  39. swollen, painful, or tender lymph glands in the neck, armpit, or groin
  40. trembling
  41. troubled breathing or swallowing
  42. twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  43. unconsciousness
  44. unpleasant breath odor
  45. unusual bleeding or bruising
  46. vomiting of blood
  47. yellow eyes or skin

Incidence not known

  1. Abdominal or stomach cramps
  2. abdominal or stomach tenderness
  3. diarrhea, watery and severe, which may also be bloody
  4. difficulty with swallowing
  5. dry cough
  6. pain
  7. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  8. unusual weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  2. diarrhea, mild
  3. difficulty having a bowel movement (stool)

Less common

  1. Anxiety
  2. back pain
  3. blurred vision
  4. cold sweats
  5. coma
  6. cool, pale skin
  7. decreased appetite
  8. depression
  9. flushed, dry skin
  10. fruit-like breath odor
  11. increased hunger
  12. increased urination
  13. itching of the vagina or outside genitals
  14. lack or loss of strength
  15. limb pain
  16. nervousness
  17. nightmares
  18. pain during sexual intercourse
  19. shakiness
  20. skin rash
  21. sleeplessness
  22. slurred speech
  23. sweating
  24. thick, white, curd-like vaginal discharge without odor or with mild odor
  25. trouble sleeping
  26. unable to sleep
  27. unexplained weight loss

Rare

  1. Acid or sour stomach
  2. bad, unusual, or unpleasant (after) taste
  3. belching
  4. change in taste
  5. continuing ringing or buzzing or other unexplained noise in the ears
  6. excess air or gas in the stomach or intestines
  7. feeling of constant movement of self or surroundings
  8. full feeling
  9. hearing loss
  10. heartburn
  11. indigestion
  12. pain or discomfort in the chest, upper stomach, or throat
  13. passing gas
  14. pressure in the stomach
  15. red, sore eyes
  16. seeing, hearing, or feeling things that are not there
  17. sensation of spinning
  18. sore mouth or tongue
  19. swelling of the abdominal or stomach area
  20. swelling or inflammation of the mouth
  21. weakness
  22. white patches in the mouth or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.