Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (18 years and older)

As an antioxidant, 250 milliliters of cranberry juice (Ocean Spray® Cranberry Select) has been taken three times daily for two weeks. Dried cranberry juice (NutriCran®90, Decas Botanical Synergies, United States) two capsules daily (400 milligrams) or two capsules three times daily (1,200 milligrams daily) has been taken for eight weeks.

For cardiovascular disease, 480 milliliters of double-strength cranberry juice (containing 54% juice, 835 milligrams of total polyphenols, and 94 milligrams of anthocyanins) has been used daily.

For diabetes, six capsules containing cranberry juice concentrate powder equivalent to 240 milliliters of cranberry juice cocktail have been used daily for six weeks.

For H. pylori infection, 250 milliliters has been used twice daily for 90 days.

For lipid-lowering effects, six capsules containing cranberry juice concentrate powder equivalent to 240 milliliters of cranberry juice cocktail has been used daily for six weeks. 125-500 milliliters of low-calorie cranberry juice has been used daily for four weeks.

For lower urinary tract symptoms (LUTS), one gelatin capsule containing 500 milligrams of cranberry fruit powder has been used three times daily for six months.

For metabolic syndrome (cardiovascular disease risk factors and antioxidant status), one cup (240 milliliters) of cranberry juice has been used twice daily, as a midmorning and early-evening snack with at least six hours in between doses, for eight weeks (for a total daily dose of 480mL).

For prevention of urinary stones, the following have been used: one quart of cranberry juice cocktail daily; eight ounces of cranberry juice four times daily for several days, then eight ounces two times daily; and one liter of cranberry juice daily for seven days. Efficacy has not been proven for these dosages.

For prevention of urinary tract infections, doses studied range from 30 to 480 milliliters (1-16 ounces) of cranberry juice cocktail 2-3 times daily for up to 40 weeks, or 15-30 milliliters of unsweetened 100% cranberry juice daily. One gram of concentrated cranberry extract (CranVerry, Aim This Way, Cambridge, MA) has been used twice daily for six months, and 1.5 ounces of frozen juice concentrate twice daily has been used. Eight ounces of cranberry juice cocktail (Ocean Spray® low-calorie juice cocktail) was taken twice daily for six months. One to three cranberry capsules (36 milligrams of cranberry proanthocyanidin; PAC) have been taken daily for 30 days. Four to five milliliters of cranberry tincture has been given three times daily (anecdotally). For a novel concentrated cranberry liquid blend (Uti-Stat®), the suggested dose was set at 60 milliliters daily. Supplements containing 200-8,000 milligrams of cranberry have been taken daily for up to six months.

For urinary tract infection treatment, 360-480 milliliters (12-16 ounces) of cranberry juice have been taken daily for up to 21 days.

Children (younger than 18 years)

There is not enough scientific evidence to suggest cranberry supplementation in children (beyond amounts found in a normal balanced diet). Cranberry been used safely in doses of 15 milliliters per kilogram. In children (2-18 years old) with neurogenic bladder receiving clean intermittent catheterization, 300 milliliters daily of cranberry juice for three months was used. High doses may cause toxicity.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com