Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Celexa

Descriptions


Citalopram is used to treat depression. It belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of citalopram in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of citalopram in the elderly. However, elderly patients are more likely to have hyponatremia (low sodium in the blood), which may require caution and an adjustment in the dose for patients receiving citalopram.

Pregnancy

Information about this citalopram-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Cisapride
  • Clorgyline
  • Dronedarone
  • Fluconazole
  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Ketoconazole
  • Levomethadyl
  • Linezolid
  • Mesoridazine
  • Methylene Blue
  • Metoclopramide
  • Moclobemide
  • Nialamide
  • Pargyline
  • Phenelzine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Procarbazine
  • Rasagiline
  • Selegiline
  • Sparfloxacin
  • Thioridazine
  • Toloxatone
  • Tranylcypromine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Alfuzosin
  • Almotriptan
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Amtolmetin Guacil
  • Ancrod
  • Anisindione
  • Antithrombin III Human
  • Apixaban
  • Apomorphine
  • Ardeparin
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Aspirin
  • Astemizole
  • Azithromycin
  • Bedaquiline
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Carbamazepine
  • Celecoxib
  • Ceritinib
  • Certoparin
  • Chloramphenicol
  • Chloroquine
  • Chlorpromazine
  • Choline Salicylate
  • Cilostazol
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Clomipramine
  • Clonixin
  • Clopidogrel
  • Clozapine
  • Cobicistat
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Dalteparin
  • Danaparoid
  • Dasatinib
  • Defibrotide
  • Dermatan Sulfate
  • Desirudin
  • Desvenlafaxine
  • Dexfenfluramine
  • Dexibuprofen
  • Dexketoprofen
  • Dextroamphetamine
  • Dextromethorphan
  • Diclofenac
  • Dicumarol
  • Diflunisal
  • Dipyridamole
  • Dipyrone
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Droperidol
  • Duloxetine
  • Efavirenz
  • Eletriptan
  • Enoxaparin
  • Eptifibatide
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Esomeprazole
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbamate
  • Felbinac
  • Fenfluramine
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fingolimod
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Formoterol
  • Frovatriptan
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Heparin
  • Hydroxytryptophan
  • Ibuprofen
  • Ibuprofen Lysine
  • Ibutilide
  • Iloperidone
  • Indomethacin
  • Iobenguane I 123
  • Itraconazole
  • Ivabradine
  • Ketoprofen
  • Ketorolac
  • Lansoprazole
  • Lapatinib
  • Levofloxacin
  • Levomilnacipran
  • Lopinavir
  • Lorcaserin
  • Lornoxicam
  • Loxoprofen
  • Lumefantrine
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Meperidine
  • Methadone
  • Mifepristone
  • Milnacipran
  • Mitotane
  • Modafinil
  • Morniflumate
  • Moxifloxacin
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Naratriptan
  • Nepafenac
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Omeprazole
  • Ondansetron
  • Oxaprozin
  • Oxcarbazepine
  • Oxyphenbutazone
  • Paliperidone
  • Pantoprazole
  • Parecoxib
  • Parnaparin
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentosan Polysulfate Sodium
  • Perflutren Lipid Microsphere
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranoprofen
  • Prasugrel
  • Primidone
  • Probenecid
  • Procainamide
  • Prochlorperazine
  • Proglumetacin
  • Promethazine
  • Propafenone
  • Propyphenazone
  • Proquazone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ranolazine
  • Rasagiline
  • Reviparin
  • Risperidone
  • Rizatriptan
  • Rofecoxib
  • Salicylic Acid
  • Salmeterol
  • Salsalate
  • Saquinavir
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Siltuximab
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Sodium Salicylate
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St John's Wort
  • Sulindac
  • Sumatriptan
  • Sunitinib
  • Tacrolimus
  • Tapentadol
  • Telithromycin
  • Tenoxicam
  • Terfenadine
  • Tetrabenazine
  • Tiaprofenic Acid
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tizanidine
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Toremifene
  • Tramadol
  • Trazodone
  • Trifluoperazine
  • Trimipramine
  • Tryptophan
  • Valdecoxib
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vilanterol
  • Vilazodone
  • Vinflunine
  • Voriconazole
  • Vortioxetine
  • Warfarin
  • Zolmitriptan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Desipramine
  • Ginkgo
  • Imipramine
  • Irinotecan
  • Lithium
  • Metoprolol
  • Rifampin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bipolar disorder (mood disorder with mania and depression), or risk of or
  • Bleeding problems or
  • Bradycardia (slow heart rate) or
  • Heart rhythm problems (eg, congenital long QT syndrome) or
  • Hyponatremia (low sodium in the blood) or
  • Mania, history of or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Heart attack, recent or
  • Heart failure or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood)—Use with caution. May cause side effects to become worse.
  • Kidney disease, severe or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

Take this medicine only as directed by your doctor, to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Citalopram may be taken with or without food. If your doctor tells you to take it at a specific time, follow your doctor's instructions.

If you are using the oral liquid, shake the bottle well before measuring each dose. Use a marked measuring spoon, oral syringe or medicine cup to measure each dose. The teaspoons and tablespoons that are used for serving and eating food do not measure exact amounts.

You may have to take citalopram for a month or longer before you begin to feel better.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (solution or tablets):
    • For depression:
      • Adults—At first, 20 milligrams (mg) once a day, taken either in the morning or evening. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg per day.
      • Older adults—20 mg once a day, taken either in the morning or evening.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits, to allow for changes in your dose and to help reduce any side effects. Blood tests may be needed to check for unwanted effects.

Do not take citalopram with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking citalopram during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping citalopram before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions.

Do not take pimozide (Orap®) while you are taking this medicine. Using these medicines together can cause very serious heart problems.

Citalopram may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use citalopram with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St. John's wort, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®). Check with your doctor first before taking any other medicines with citalopram.

Citalopram may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you or your caregiver notice any of these unwanted effects, tell your doctor right away. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or irregular heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation or slow heartbeat.

Do not suddenly stop taking this medicine without checking with your doctor first. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This will decrease the chance of having withdrawal symptoms such as agitation, breathing problems, chest pain, confusion, diarrhea, dizziness or lightheadedness, fast heartbeat, headache, increased sweating, muscle pain, nausea, restlessness, runny nose, trouble in sleeping, trembling or shaking, unusual tiredness or weakness, vision changes, or vomiting.

This medicine may increase your risk for bleeding problems. Make sure your doctor knows if you are also taking other medicines that thin the blood, such as aspirin, nonsteroidal antiinflammatory agents, also called NSAIDs (eg, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or warfarin (Coumadin®, Jantoven®).

This medicine may cause hyponatremia (low sodium in the blood). This is more common in elderly patients, those who are taking diuretic medicines for high blood pressure, or those who have decreased amounts of fluid in the body due to severe diarrhea or vomiting. Check with your doctor right away if you have confusion, headache, memory problems, trouble concentrating, weakness, or feel unsteady when standing.

The use of alcohol is not recommended in patients who are taking this medicine.

This medicine may cause some people to become drowsy, to have trouble thinking, or to have problems with movement. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or well-coordinated.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

  1. Agitation
  2. blurred vision
  3. confusion
  4. fever
  5. increase in the frequency of urination or amount of urine produced
  6. lack of emotion
  7. loss of memory
  8. menstrual changes
  9. skin rash or itching
  10. trouble with breathing

Rare

  1. Behavior change similar to drunkenness
  2. bleeding gums
  3. breast tenderness or enlargement or unusual secretion of milk (in females)
  4. chills
  5. convulsions (seizures)
  6. diarrhea
  7. difficulty with concentrating
  8. dizziness or fainting
  9. drowsiness
  10. increased hunger
  11. increased thirst
  12. irregular heartbeat
  13. lack of energy
  14. lethargy
  15. nosebleed
  16. overactive reflexes
  17. painful urination
  18. poor coordination
  19. purple or red spots on the skin
  20. rapid weight gain
  21. red or irritated eyes
  22. redness, tenderness, itching, burning, or peeling of the skin
  23. shivering
  24. slow or irregular heartbeat (less than 50 beats per minute)
  25. sore throat
  26. stupor
  27. sweating
  28. swelling of the face, ankles, or hands
  29. talking or acting with excitement you cannot control
  30. trembling, shaking, or twitching
  31. trouble with holding or releasing urine
  32. unusual or sudden body or facial movements or postures
  33. unusual tiredness or weakness

Incidence not known

  1. Abdominal or stomach pain
  2. back or leg pains
  3. black, tarry stools
  4. bloating
  5. bloody stools
  6. chest pain
  7. confusion as to time, place, or person
  8. constipation
  9. cough
  10. darkened urine
  11. difficult or fast breathing
  12. difficulty with swallowing
  13. drooling
  14. fast, slow, or irregular heartbeat
  15. general body swelling
  16. hive-like swelling on the face, eyelids, lips, tongue, or throat
  17. hives
  18. holding false beliefs that cannot be changed by fact
  19. impaired consciousness, ranging from confusion to coma
  20. indigestion
  21. itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  22. loss of appetite
  23. loss of bladder control
  24. loss of consciousness
  25. muscle cramps or spasms
  26. muscle tightness
  27. muscle twitching or jerking
  28. pale skin
  29. penile erections, frequent or continuing
  30. recurrent fainting
  31. rhythmic movement of the muscles
  32. seeing, hearing, or feeling things that are not there
  33. shortness of breath
  34. swelling of the breasts or unusual milk production
  35. tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  36. tightness in the chest
  37. total body jerking
  38. twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  39. uncontrolled jerking or twisting movements
  40. unusual excitement
  41. vomiting of blood or material that looks like coffee grounds
  42. yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Decrease in sexual desire or ability
  2. sleepiness or unusual drowsiness

Less common

  1. Body aches or pain
  2. change in sense of taste
  3. gas
  4. headache (severe and throbbing)
  5. heartburn
  6. increased sweating
  7. increased yawning
  8. loss of voice
  9. pain in the muscles or joints
  10. sneezing
  11. stuffy or runny nose
  12. tingling, burning, or prickly feelings on the skin
  13. tooth grinding
  14. unusual increase or decrease in weight
  15. watering of the mouth

Incidence not known

  1. Bruising
  2. inability to sit still
  3. large, flat, blue or purplish patches in the skin
  4. need to keep moving
  5. uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.