Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

Avoid in people with a known allergy or sensitivity to chondroitin sulfate products or to shellfish, especially shrimp.

Side Effects and Warnings

Chondroitin is likely safe when taken by mouth appropriately for osteoarthritis. Safety information is lacking for chronic use lasting longer than three years. Chondroitin is likely safe when applied appropriately to the skin or to the eyes.

Chondroitin is possibly safe when injected into the muscle or vein.

Sources report that there may be a risk of acquiring mad cow disease from ingesting chondroitin that is derived from bovine tissue. The U.S. Food and Drug Administration (FDA) suggests caution when consuming bovine tissue from countries with mad cow disease.

Chondroitin may increase the risk of bleeding. Caution is advised in people with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.

Use cautiously in people who have asthma. Chondroitin may worsen asthma symptoms.

Use cautiously in people who have heart disorders. Chondroitin may cause changes in heart rhythm, congestive heart failure, heart attack, and increased blood pressure.

Use cautiously in people who have skin conditions. Chondroitin may cause hair loss, hives, rash, skin irritation, and sun sensitivity.

Use cautiously in people who have swelling. Chondroitin may cause swelling in the lower limbs and eyelids.

Use cautiously in people who have stomach disorders. Chondroitin may cause constipation, diarrhea, feeling of burning in the stomach, heartburn, indigestion, nausea, stomach inflammation, stomach pain, stomach ulcers, and vomiting.

Use cautiously in people who have glaucoma. Chondroitin may increase eye pressure.

Use cautiously in people who have weakened immune systems. Chondroitin may increase the risk of viral infection.

Use cautiously in people who have nervous system disorders. Chondroitin may affect the nervous system, and cause headache or movement problems.

Use cautiously in children and in pregnant or breastfeeding women, due to a lack of safety information.

Use cautiously in people who have mental illnesses. Chondroitin may cause feelings of euphoria (intense happiness or well-being).

Avoid in people who are at risk of or have prostate cancer. Chondroitin may promote spread or recurrence of prostate cancer.

Avoid in people who have liver disorders. Chondroitin may cause changes in levels of liver enzymes or liver toxicity.

Avoid in people with a known allergy or sensitivity to chondroitin sulfate products or to shellfish, especially shrimp.

Chondroitin may also cause a burning sensation in the genitals, chest pain, ear inflammation, frequent or painful urination, hearing problems, pelvic pain, severe allergic reaction, sickliness, tightness in the throat or chest, urinary tract infection, and vaginal inflammation.

Pregnancy and Breastfeeding

There is a lack of scientific evidence on the use of chondroitin during pregnancy or breastfeeding.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com