Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Cancidas

Descriptions


Caspofungin is an antifungal medicine. It is used to help the body overcome serious fungus infections, including Candida and Aspergillosis infections. It is also used to treat serious fungus infections when other medicines (e.g., amphotericin B, itraconazole) have failed.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of caspofungin in children. Safety and efficacy have not been established in children below 3 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of caspofungin in the elderly.

Pregnancy

Information about this caspofungin-intravenous-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine
  • Tacrolimus

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine
  • Dexamethasone
  • Efavirenz
  • Fosphenytoin
  • Nevirapine
  • Phenytoin
  • Rifampin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Liver disease, moderate to severe (e.g. hepatitis, liver failure)—Higher blood levels of caspofungin may result, increasing the chance of side effects.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so the needle will remain in place for about 1 hour.

Precautions

It is very important that your doctor check the progress of you or your child while you are taking this medicine to make sure the medicine has worked properly. Blood tests may be needed to check for unwanted effects.

Check with your doctor right away if you or your child have any symptoms of liver problems including dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, or yellowing of your skin or the whites of your eyes.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Bloating or swelling of the face, arms, hands, lower legs, or feet
  2. blue lips, fingernails, or skin
  3. blurred vision
  4. changes in skin color
  5. chest pain
  6. confusion
  7. convulsions (seizures)
  8. cough
  9. cracked lips
  10. decreased urine
  11. diarrhea
  12. difficult or troubled breathing
  13. difficulty with swallowing
  14. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  15. dry mouth
  16. fever
  17. headache
  18. increased thirst
  19. irregular heartbeat
  20. irregular, fast or slow, or shallow breathing
  21. loss of appetite
  22. mood changes
  23. muscle pain or cramps
  24. nausea or vomiting
  25. nervousness
  26. numbness or tingling in your hands, feet, or lips
  27. pain or redness at the injection site
  28. pain, tenderness, or swelling of the foot or leg
  29. pale skin
  30. pounding in the ears
  31. rapid weight gain
  32. shortness of breath
  33. slow or fast heartbeat
  34. sneezing
  35. sore throat
  36. sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  37. sweating
  38. tightness in the chest
  39. troubled breathing with exertion
  40. unusual bleeding or bruising
  41. unusual tiredness or weakness
  42. unusual weight gain or loss
  43. wheezing

Less common

  1. Bloody urine
  2. decreased frequency or amount of urine
  3. increased blood pressure
  4. lower back or side pain
  5. weight gain
  6. yellow eyes or skin

Incidence not known

  1. Abdominal or stomach pain or tenderness
  2. black, tarry stools
  3. bladder pain
  4. bleeding gums
  5. blood in the urine or stools
  6. bloody nose
  7. chest pain or discomfort
  8. clay-colored stools
  9. cloudy urine
  10. constipation
  11. dark urine
  12. decreased appetite
  13. depression
  14. drowsiness
  15. fever with or without chills
  16. flushed, dry skin
  17. frequent urge to urinate
  18. fruit-like breath odor
  19. general feeling of tiredness or weakness
  20. incoherent speech
  21. increased hunger
  22. increased urination
  23. indigestion
  24. itching
  25. light-colored stools
  26. metallic taste
  27. muscle spasms (tetany) or twitching seizures
  28. muscle weakness
  29. no blood pressure or pulse
  30. noisy, rattling breathing pain or discomfort in arms, jaw, back, or neck
  31. pains in stomach, side, or abdomen, possibly radiating to the back
  32. pinpoint red spots on skin
  33. rapid, shallow breathing
  34. rapid weight gain
  35. rash
  36. right upper abdominal or stomach pain and fullness
  37. shakiness in the legs, arms, hands, or feet
  38. stomach pain, continuing
  39. stopping of heart
  40. trembling or shaking of hands or feet
  41. troubled breathing at rest
  42. ulcers, sores, or white spots in the mouth
  43. unconsciousness
  44. unexplained weight loss
  45. unpleasant breath odor
  46. vomiting of blood
  47. weakness
  48. weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Flushing, redness of skin
  2. unusually warm skin

Incidence not known

  1. Acid or sour stomach
  2. back pain
  3. belching
  4. blistering, peeling, or loosening of skin
  5. bumps on skin
  6. difficulty in moving
  7. dry, red, hot, or irritated skin
  8. fear
  9. flaking and falling off of skin
  10. full or bloated feeling
  11. heartburn
  12. hives or welts
  13. indigestion
  14. joint or muscle pain
  15. lack or loss of strength
  16. muscle pain or stiffness
  17. pressure in the stomach
  18. red skin lesions, often with a purple center
  19. red, irritated eyes
  20. redness of skin
  21. sleepiness or unusual drowsiness
  22. sleeplessness
  23. small red or purple spots on skin
  24. stomach discomfort, upset, or pain
  25. swelling of abdominal or stomach area
  26. trouble sleeping
  27. unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.