Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Kyprolis


Carfilzomib injection is used alone or together with other medicines to treat multiple myeloma (a type of bone marrow cancer) in patients who have received at least 2 prior treatments that did not work well. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Carfilzomib is an antineoplastic agent (cancer medicine).

This medicine is to be given only by or under the supervision of your doctor.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of carfilzomib injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of carfilzomib injection in the elderly.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots (eg, deep vein thrombosis, pulmonary embolism) or
  • Congestive heart failure or
  • Heart attack, recent or
  • Heart disease (eg, angina, cardiomyopathy) or
  • Hypertension (high blood pressure) or
  • Kidney disease or
  • Liver disease or
  • Lung or breathing problems (eg, acute respiratory distress syndrome, interstitial lung disease, pneumonitis) or
  • Pulmonary edema or
  • Pulmonary hypertension (a lung disease) or
  • Thrombocytopenia (low platelets in the blood)—Use with caution. May make these conditions worse.

Proper Use

A nurse or other trained health professional will give you this medicine in a hospital or cancer clinic. This medicine is given through a needle placed in a vein.

This medicine needs to be given on a fixed schedule. Be sure to keep all appointments.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems and other unwanted effects.

You might also receive medicines (eg, dexamethasone) to help prevent unwanted reactions to the injection.


It is very important that your doctor check you at regular visits while you are receiving this medicine to make sure that the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control while you are using this medicine to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause serious heart problems. Tell your doctor right away if you have chest pain or discomfort, shortness of breath, irregular heartbeats, or swelling of the feet, ankles, or legs while you are receiving this medicine.

Kidney problems may occur while you are receiving this medicine. Tell your doctor if you have the following symptoms: agitation, confusion, decreased urine output, depression, headache, rapid weight gain, swelling the face, ankles, or hands, or unusual tiredness or weakness.

This medicine may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor right away if you have a change in how much or how often you urinate, rapid weight gain, muscle or joint pain, swelling of the feet or lower legs, or feel tired.

Blood clots may occur while you are receiving this medicine. Tell your doctor right away if you have chest pain, dizziness or lightheadedness, fainting, fast heartbeat, pain, redness, or swelling in the arm or legs, sudden shortness of breath, trouble breathing.

This medicine may cause you to be more dizzy, lightheaded, or tired than normal. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Getting up slowly from a sitting or lying position may help prevent lightheadedness or dizziness. Tell your doctor if you feel dizzy or lightheaded.

This medicine may cause a serious type of allergic reaction called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a cough, difficulty with swallowing, dizziness, a fast heartbeat, chest tightness, trouble breathing, swelling in your face or hands, a fever, chills, itching or hives, or lightheadedness or faintness while you are receiving this medicine.

This can lower the number of your platelets, which are necessary for proper blood clotting. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, or pinpoint red spots on your skin while receiving this medicine.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Tell your doctor right away if you have seizures, headache, confusion, vision problems, unusual drowsiness, tiredness, or weakness. These could be symptoms of posterior reversible encephalopathy syndrome (PRES).

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Agitation
  2. black, tarry stools
  3. bleeding gums
  4. bloating or swelling of the face, arms, hands, lower legs, or feet
  5. blood in the urine or stools
  6. blurred vision
  7. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  8. chest pain
  9. coma
  10. confusion
  11. cough or hoarseness
  12. decreased urine output
  13. depression
  14. difficult or labored breathing
  15. difficulty with moving
  16. dizziness
  17. drowsiness
  18. fast or irregular heartbeat
  19. headache
  20. hostility
  21. irregular heartbeat
  22. irritability
  23. lethargy
  24. lower back or side pain
  25. muscle spasms (tetany) or twitching
  26. nausea or vomiting
  27. numbness or tingling in the hands, feet, or lips
  28. painful or difficult urination
  29. pale skin
  30. pinpoint red spots on the skin
  31. pounding in the ears
  32. rapid weight gain
  33. seizures
  34. slow or fast heartbeat
  35. stupor
  36. tightness in the chest
  37. tingling of the hands or feet
  38. trembling
  39. troubled breathing with exertion
  40. ulcers, sores, or white spots in the mouth
  41. unsteadiness or awkwardness
  42. unusual bleeding or bruising
  43. unusual tiredness or weakness
  44. unusual weight gain or loss

Less common

  1. Chills
  2. fever
  3. muscle pain or cramps
  4. painful blisters on the trunk of the body
  5. weakness in the arms, hands, legs, or feet


  1. Dark-colored urine
  2. general feeling of discomfort or illness
  3. general feeling of tiredness or weakness
  4. light-colored stools
  5. stomach pain, continuing
  6. thickening of bronchial secretions
  7. yellow eyes or skin

Incidence not known

  1. Blindness
  2. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  3. fainting
  4. joint pain, stiffness, or swelling
  5. seizures
  6. stomach pain
  7. sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Back pain
  2. body aches or pain
  3. bone pain
  4. constipation
  5. diarrhea
  6. dry mouth
  7. ear congestion
  8. flushed, dry skin
  9. fruit-like breath odor
  10. increased hunger
  11. increased thirst
  12. increased urination
  13. loss of appetite
  14. loss of voice
  15. metallic taste
  16. muscle weakness
  17. pain in the arms or legs
  18. runny nose
  19. sneezing
  20. sore throat
  21. trouble sleeping
  22. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.