Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Bumex

Descriptions


Bumetanide belongs to a group of medicines called loop diuretics or "water pills." Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .

This medicine is available only with your doctor's prescription .

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bumetanide injection in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of bumetanide injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney or heart problems, which may require an adjustment of dosage in patients receiving bumetanide injection .

Pregnancy

Information about this bumetanide-injection-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Arsenic Trioxide
  • Bepridil
  • Digitoxin
  • Dofetilide
  • Droperidol
  • Ketanserin
  • Levomethadyl
  • Lithium
  • Metolazone
  • Sotalol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Amtolmetin Guacil
  • Aspirin
  • Benazepril
  • Bromfenac
  • Bufexamac
  • Captopril
  • Celecoxib
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Delapril
  • Dexibuprofen
  • Dexketoprofen
  • Dibekacin
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Enalaprilat
  • Enalapril Maleate
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Germanium
  • Ginseng
  • Gossypol
  • Ibuprofen
  • Ibuprofen Lysine
  • Imidapril
  • Indomethacin
  • Kanamycin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Neomycin
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranoprofen
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Ramipril
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Spirapril
  • Streptomycin
  • Sulindac
  • Temocapril
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Trandolapril
  • Valdecoxib
  • Zofenopril

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anuria (not able to form urine) or
  • Liver disease, severe (e.g., hepatic coma)—Should not use in patients with these conditions .
  • Dehydration or
  • Gout or
  • Hearing problems or
  • Hyperuricemia (high uric acid in the blood) or
  • Hypocalcemia (low calcium in the blood) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypovolemia (low blood volume) or
  • Thrombocytopenia (low platelets in the blood)—Use with caution. This medicine may make these conditions worse .
  • Diabetes—This medicine may increase the amount of sugar in the blood .
  • Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body .

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins .

Precautions

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor .

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Abdominal pain
  2. blurred vision
  3. confusion
  4. decreased urine output
  5. dizziness
  6. drowsiness
  7. dry mouth
  8. fast or irregular heartbeat
  9. flushed, dry skin
  10. fruit-like breath odor
  11. headache
  12. increased hunger
  13. increased thirst
  14. increased urination
  15. irritability
  16. joint pain, stiffness, or swelling
  17. loss of appetite
  18. loss of mental alertness
  19. lower back, side, or stomach pain
  20. mood or mental changes
  21. muscle pain or cramps
  22. nausea or vomiting
  23. numbness or tingling in the hands, feet, or lips
  24. shortness of breath
  25. sweating
  26. swelling of face, hands, feet, ankles, or lower legs
  27. troubled breathing
  28. unexplained weight loss
  29. unusual tiredness or weakness
  30. weak pulse

Rare

  1. Agitation
  2. back pain
  3. black, tarry stools
  4. bleeding gums
  5. blood in the urine or stools
  6. chest pain
  7. convulsions (seizures)
  8. deep or fast breathing with dizziness
  9. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  10. fever
  11. hallucinations
  12. hives
  13. increase in heart rate
  14. increased blood pressure
  15. numbness of feet, hands, and around the mouth
  16. pinpoint red spots on the skin
  17. rapid breathing
  18. stiff neck
  19. sunken eyes
  20. trembling, jerking of hands
  21. unusual bleeding or bruising
  22. weight gain
  23. wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Difficulty breathing
  2. pain in chest, groin, or legs, especially the calves
  3. severe, sudden headache
  4. slurred speech
  5. sudden loss of coordination
  6. sudden, severe weakness or numbness in the arm or leg
  7. sudden, unexplained shortness of breath
  8. tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area
  9. unusual drowsiness, dullness, or feeling of sluggishness
  10. vision changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  1. Decreased interest in sexual intercourse
  2. diarrhea
  3. difficulty with moving
  4. ear discomfort
  5. feeling of constant movement of self or surroundings
  6. inability to have or keep an erection
  7. itching skin
  8. loss in sexual ability, desire, drive, or performance
  9. muscle or bone pain
  10. muscle stiffness
  11. nipple tenderness
  12. pain, swelling, or redness in joints
  13. rash
  14. sensation of spinning
  15. shorter than usual time to ejaculation of semen
  16. trouble with hearing
  17. upset stomach

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.