Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Adcetris

Descriptions


Brentuximab injection is used to treat a type of cancer called Hodgkin's lymphoma (HL). It is given to patients who have received an autologous stem cell transplant (ASCT) or other cancer treatments that did not work well.

Brentuximab injection is also used to treat patients with systemic anaplastic large cell lymphoma (sALCL). It is used after at least one other cancer medicine was given and did not work well.

Brentuximab interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by brentuximab, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, such as a skin rash, may not be serious but may cause concern. Some effects do not occur until months or years after the medicine is used.

This medicine is to be administered only by or under the immediate supervision of your doctor.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of brentuximab injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of brentuximab injection in the geriatric population. Safety and efficacy have not been established.

Pregnancy

Information about this brentuximab-intravenous-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bleomycin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aprepitant
  • Atazanavir
  • Carbamazepine
  • Ceritinib
  • Clarithromycin
  • Cobicistat
  • Crizotinib
  • Dabrafenib
  • Eslicarbazepine Acetate
  • Fosaprepitant
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Mitotane
  • Nefazodone
  • Nelfinavir
  • Piperaquine
  • Primidone
  • Ritonavir
  • Saquinavir
  • Siltuximab
  • Telithromycin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood or bone marrow problems (e.g., neutropenia) or
  • Peripheral neuropathy (nerve problem)—Use with caution. May make these conditions worse.
  • Infection—May decrease your body's ability to fight infection.

Proper Use

Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

This medicine must be given slowly, so the needle will remain in place for 30 minutes. It is usually given every 3 weeks until your condition improves. You may also receive medicines (e.g., acetaminophen, steroid medicines) to help prevent possible allergic reactions to the injection.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

Do not take this medicine together with bleomycin (Blenoxane®). Using these medicines together may cause serious side effects, such as cough, shortness of breath, troubled breathing, or wheezing

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

This medicine may cause a serious side effect called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a fever, chills, trouble with breathing, lightheadedness, fainting, or chest pain within a few hours after you receive it.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are receiving this medicine.

Check with your doctor if you notice any signs of fever, chills, sore throat, or painful urination. These could be symptoms of an infection resulting from low white blood cell counts.

This medicine may cause a serious type of reaction called tumor lysis syndrome (TLS). Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount; joint pain, stiffness, or swelling; lower back, side, or stomach pain; a rapid weight gain; swelling of the feet or lower legs; or unusual tiredness or weakness.

Serious skin reactions can occur during treatment with this medicine. Stop using this medicine and check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.

This medicine may cause a rare and serious brain infection called progressive multifocal leukoencephalopathy (PML). Talk to your doctor about the benefits of using this medicine and the risk of this infection. Check with your doctor right away if you are having more than one of these symptoms: vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, and weakness in the legs.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Black, tarry stools
  2. bleeding gums
  3. blood in the urine or stools
  4. body aches or pain
  5. burning, numbness, tingling, or painful sensations
  6. chills
  7. cough
  8. difficult or labored breathing
  9. difficulty with breathing
  10. ear congestion
  11. fever
  12. headache
  13. loss of voice
  14. lower back or side pain
  15. pain
  16. painful or difficult urination
  17. pale skin
  18. pinpoint red spots on the skin
  19. shortness of breath
  20. sneezing
  21. sore throat
  22. stuffy or runny nose
  23. swollen, painful, or tender lymph glands in the neck, armpit, or groin
  24. tightness in the chest
  25. troubled breathing with exertion
  26. ulcers, sores, or white spots in the mouth
  27. unsteadiness or awkwardness
  28. unusual bleeding or bruising
  29. unusual tiredness or weakness
  30. weakness in the arms, hands, legs, or feet
  31. wheezing

Less common

  1. Anxiety
  2. back pain
  3. bladder pain
  4. blistering, peeling, or loosening of the skin
  5. bloating or swelling of the face, arms, hands, lower legs, or feet
  6. blurred vision
  7. chest pain
  8. cloudy urine
  9. confusion
  10. convulsions
  11. diarrhea
  12. dizziness or lightheadedness
  13. drowsiness
  14. fainting
  15. fast heartbeat
  16. frequent urge to urinate
  17. general feeling of discomfort or illness
  18. irregular heartbeat
  19. itching
  20. joint pain, stiffness, or swelling
  21. muscle pain
  22. rapid weight gain
  23. red skin lesions, often with a purple center
  24. red, irritated eyes
  25. severe pain in the chest
  26. stomach pain
  27. sudden onset of severe breathing difficulty
  28. sudden shortness of breath or troubled breathing
  29. thickening of bronchial secretions
  30. troubled breathing
  31. unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Decreased appetite or weight
  2. difficulty having a bowel movement (stool)
  3. difficulty with moving
  4. hair loss or thinning of the hair
  5. muscle spasms
  6. muscle stiffness
  7. nausea
  8. night sweats
  9. pain in the arms or legs
  10. rash
  11. sleeplessness
  12. trouble with sleeping
  13. unable to sleep
  14. vomiting

Less common

  1. Dry skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.