Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Cogentin

Descriptions


Benztropine injection is used with other medicines to treat Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines that are used to treat nervous, mental, and emotional conditions (e.g., phenothiazine medicine such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®).

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Because of benztropine's toxicity, it should be used with caution in children 3 years of age or older. It is not recommended for use in children below 3 years of age.

Geriatric

No information is available on the relationship of age to the effects of benztropine injection in geriatric patients.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Potassium

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Morphine
  • Morphine Sulfate Liposome
  • Oxymorphone
  • Umeclidinium

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Betel Nut
  • Chlorpromazine
  • Haloperidol

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Enlarged prostate or
  • Glaucoma or
  • Paralytic ileus (bowel blockage), history of or
  • Psychosis (mental disorder) or
  • Tachycardia (fast heartbeat) or
  • Urinating problems (e.g., painful or difficult urination, urinary retention)—Use with caution. May make these conditions worse.
  • Glaucoma, angle-closure or
  • Tardive dyskinesia (movement disorder)—Should not be used in patients with these conditions.

Proper Use

A nurse or other trained health professional will give you this medicine in a hospital. This medicine may be given as a shot into one of your muscles or given through a needle placed in one of your veins.

Precautions

It is important that your doctor check your progress at regular visits to allow changes in your dose and to check for any unwanted effects.

Benztropine injection may cause dizziness, trouble in controlling movements, or trouble in thinking or seeing clearly. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

Do not stop taking this medicine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping completely.

This medicine may make you sweat less, causing your body temperature to increase. Use extra care to avoid becoming overheated during exercise or hot weather while you are taking this medicine, since overheating may result in heat stroke.

This medicine may cause muscle weakness. If you have concerns about this, check with your doctor.

If you develop any unusual or strange thoughts and behavior while receiving benztropine injection, be sure to discuss it with your doctor. Some changes that have occurred in people receiving this medicine are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, visual hallucinations (seeing things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking this medicine.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  1. Abdominal or stomach cramps or pain
  2. aggressive and violent behavior
  3. being forgetful
  4. bloating
  5. burning while urinating
  6. confusion about identity, place, and time
  7. constipation
  8. decrease in frequency of urination
  9. decrease in urine volume
  10. diarrhea
  11. difficult or painful urination
  12. difficulty in passing urine (dribbling)
  13. difficulty with speaking
  14. difficulty with swallowing
  15. discouragement
  16. dizziness
  17. dry mouth
  18. extremely high fever or body temperature
  19. fast, pounding, or irregular heartbeat or pulse
  20. fast, shallow breathing
  21. fast, weak heartbeat
  22. feeling sad or empty
  23. fever
  24. headache
  25. hot, dry skin
  26. irritability
  27. lack of appetite
  28. lack of sweating
  29. listlessness
  30. loss of interest or pleasure
  31. mood or mental changes
  32. muscle cramps
  33. muscle weakness
  34. nervousness
  35. numbness of the fingers
  36. pale, clammy skin
  37. seeing things that are not there
  38. thirst
  39. tiredness
  40. trouble concentrating
  41. trouble with sleeping
  42. vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Blindness
  2. blurred vision
  3. change in consciousness
  4. cold, clammy skin
  5. decreased vision
  6. dizziness
  7. eye pain
  8. holding false beliefs that cannot be changed by fact
  9. lightheadedness
  10. loss of consciousness
  11. muscle weakness
  12. nausea or vomiting
  13. no breathing
  14. nosebleeds
  15. numbness or tingling in the face, arms, or legs
  16. shakiness and unsteady walk
  17. sweating
  18. tearing
  19. unsteadiness, trembling, or other problems with muscle control or coordination
  20. unusual excitement, nervousness, or restlessness
  21. vision problems
  22. wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Enlarged pupils
  2. loss of appetite
  3. skin rash
  4. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.