Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Zithromax
  2. Zithromax Tri-Pak
  3. Zithromax Z-Pak
  4. Zmax

Descriptions


Azithromycin is used to treat certain bacterial infections in many different parts of the body. This medicine may mask or delay the symptoms of syphilis. It is not effective against syphilis infections.

Azithromycin belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Suspension
  • Tablet
  • Powder for Suspension, Extended Release
  • Capsule

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Safety and efficacy have not been established for the treatment of sinusitis in pediatric patients or for infants younger than 6 months of age. Appropriate studies have not been performed on the relationship of age to the effects of azithromycin to treat sinusitis in children or to treat pneumonia in children younger than 6 months of age.

Appropriate studies have not been performed on the relationship of age to the effects of azithromycin oral suspension and tablets to treat pharyngitis or tonsillitis in children younger than 2 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of azithromycin in the elderly. However, elderly patients are more likely to have heart rhythm problems (e.g., torsades de pointes) which may require caution in patients receiving azithromycin.

Pregnancy

Information about this azithromycin-oral-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Cisapride
  • Dihydroergotamine
  • Dronedarone
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Mesoridazine
  • Methylergonovine
  • Methysergide
  • Pimozide
  • Piperaquine
  • Sparfloxacin
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Afatinib
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Apomorphine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Bosutinib
  • Bretylium
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Desipramine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Erythromycin
  • Escitalopram
  • Everolimus
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Levofloxacin
  • Lopinavir
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Mifepristone
  • Moxifloxacin
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Paliperidone
  • Pazopanib
  • Perflutren Lipid Microsphere
  • Pixantrone
  • Pomalidomide
  • Posaconazole
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Romidepsin
  • Salmeterol
  • Saquinavir
  • Sematilide
  • Sevoflurane
  • Simvastatin
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sunitinib
  • Tedisamil
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Toremifene
  • Trabectedin
  • Trazodone
  • Trifluoperazine
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Voriconazole
  • Warfarin
  • Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atorvastatin
  • Digoxin
  • Fentanyl
  • Lovastatin
  • Nelfinavir
  • Rifabutin
  • Theophylline

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to any macrolide and ketolide antibiotic (e.g., clarithromycin, erythromycin, telithromycin, Biaxin®, Ery-tab®, or Ketek®) or
  • Liver disease with prior azithromycin use, history of—Should not be used in patients with this condition.
  • Bacteremia (blood infection) or
  • Cystic fibrosis or
  • Infections, nosocomial or hospital-acquired or
  • Weak immune system or
  • Weakened physical condition—Zithromax® should not be used in patients with these conditions to treat pneumonia.
  • Bradycardia (slow heartbeat) or
  • Hypokalemia (low potassium in the blood), uncorrected or
  • Hypomagnesemia (low magnesium in the blood), uncorrected—Use is not recommended in patients with these conditions.
  • Congestive heart failure or
  • Diarrhea or
  • Heart disease or
  • Heart rhythm problems (e.g., prolonged QT interval), history of or
  • Myasthenia gravis (severe muscle weakness)—Use with caution. May make these conditions worse.
  • Kidney disease, severe or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You may take Zithromax® oral liquid or tablets with or without food.

Shake well the bottle of Zithromax® oral liquid before each use. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Measure the extended-release oral liquid with a marked measuring spoon, syringe, or cup. You or your child must take this medicine within 12 hours after it has been mixed with water. It is best to take the extended-release oral liquid on an empty stomach or at least 1 hour before or 2 hours after a meal. If your child does not use all of the medicine in the bottle, throw it away after you give the dose.

If you or your child vomits within one hour of taking the extended-release oral liquid, call your doctor right away to see if more medicine is needed.

Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

If you are taking aluminum or magnesium-containing antacids, do not take them at the same time that you take Zithromax®. These medicines may keep azithromycin from working properly. However, you can take antacids with Zmax®.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release suspension):
    • For treatment of pneumonia:
      • Adults—2 grams (g) once as a single dose.
      • Children weighing 75 pounds (34 kg) or more—2 g once as a single dose.
      • Children and infants 6 months of age and older weighing less than 75 pounds (34 kg)—Dose is based on body weight and must be determined by your doctor. The dose is usually 60 milligrams (mg) per kilogram (kg) of body weight once as a single dose.
    • For treatment of sinusitis:
      • Adults—2 grams (g) once a day as a single dose.
      • Children—Use and dose must be determined by your doctor.
  • For oral dosage forms (suspension or tablets):
    • For treatment of infections:
      • Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days.
      • Children and infants 6 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 30 milligrams (mg) per kilogram (kg) of body weight once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 5 to 10 mg/kg of body weight once a day for several days.
      • Infants younger than 6 months of age—Use and dose must be determined by your doctor.
    • For treatment of pharyngitis or tonsillitis:
      • Adults—500 milligrams (mg) on Day1 (the first day), taken as a single dose. Then, 250 mg on Day 2 through Day 5.
      • Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight once a day for 5 days.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not refrigerate or freeze the extended-release oral liquid. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.

You may store the oral liquid at room temperature or in the refrigerator. Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed.

Precautions

It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

If you or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you take this medicine.

Serious skin reactions can occur with this medicine. Stop using this medicine and check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.

Stop using this medicine and check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

Azithromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you or your child have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you or your child have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Diarrhea
  2. loose stools

Less common

  1. Blistering, crusting, irritation, itching, or reddening of the skin
  2. cracked, dry, or scaly skin
  3. fever
  4. swelling

Rare

  1. Abdominal or stomach pain
  2. blistering, peeling, or loosening of the skin
  3. bloody or cloudy urine
  4. bloody, black, or tarry stools
  5. body aches or pain
  6. burning while urinating
  7. chest pain
  8. chills
  9. congestion
  10. cough increased
  11. cough producing mucus
  12. dark urine
  13. difficult or labored breathing
  14. difficult or painful urination
  15. dizziness
  16. drowsiness
  17. dryness or soreness of the throat
  18. earache
  19. fainting
  20. fast, irregular, pounding, or racing heartbeat or pulse
  21. general feeling of discomfort or illness
  22. general feeling of tiredness or weakness
  23. headache
  24. indigestion
  25. irregular or slow heart rate
  26. itching
  27. joint or muscle pain
  28. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  29. light-colored stools
  30. loss of appetite
  31. muscle aches and pains
  32. nausea or vomiting
  33. noisy breathing
  34. passing of gas
  35. rash
  36. red skin lesions, often with a purple center
  37. red, irritated eyes
  38. redness or swelling in the ear
  39. runny nose
  40. shivering
  41. shortness of breath
  42. sneezing
  43. sores, ulcers, or white spots on the lips or in the mouth
  44. stomach pain, continuing
  45. stomach pain, fullness, or discomfort
  46. stuffy nose
  47. sweating
  48. swelling of the face, ankles, hands, feet, or lower legs
  49. tender, swollen glands in the neck
  50. tightness in the chest
  51. trouble with sleeping
  52. trouble with swallowing
  53. unpleasant breath odor
  54. unusual bleeding or bruising
  55. unusual tiredness or weakness
  56. upper right abdominal or stomach pain
  57. voice changes
  58. vomiting of blood
  59. wheezing
  60. yellow eyes or skin

Incidence not known

  1. Abdominal or stomach cramps or tenderness
  2. bleeding gums
  3. bloating
  4. blood in the urine or stools
  5. blurred vision
  6. change in hearing
  7. clay-colored stools
  8. coma
  9. confusion
  10. constipation
  11. continuing ringing or buzzing or other unexplained noise in the ears
  12. decreased urine output
  13. depression
  14. diarrhea, watery and severe, which may also be bloody
  15. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  16. fainting
  17. greatly decreased frequency of urination or amount of urine
  18. hives
  19. hostility
  20. increased thirst
  21. irritability
  22. lethargy
  23. loss of hearing
  24. lower back or side pain
  25. muscle twitching
  26. pains in the stomach, side, or abdomen, possibly radiating to the back
  27. pale skin
  28. pinpoint red spots on the skin
  29. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  30. rapid weight gain
  31. seizures
  32. stupor
  33. unusual weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  1. Acid or sour stomach
  2. aggressive or angry
  3. bad, unusual, or unpleasant (after) taste
  4. belching
  5. burning feeling in the chest or stomach
  6. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  7. change in taste
  8. changes in the color of the tongue
  9. crying
  10. depersonalization
  11. dry mouth
  12. dysphoria
  13. euphoria
  14. excess air or gas in the stomach or intestines
  15. feeling of constant movement of self or surroundings
  16. full feeling
  17. heartburn
  18. hyperventilation
  19. increase in body movements
  20. itching of the vagina or genital area
  21. lack or loss of strength
  22. mental depression
  23. nervousness
  24. pain during sexual intercourse
  25. paranoia
  26. quick to react or overreact emotionally
  27. rapidly changing moods
  28. rash with flat lesions or small raised lesions on the skin
  29. redness of the skin
  30. restlessness
  31. sensation of spinning
  32. shaking
  33. shortness of breath
  34. sleepiness or unusual drowsiness
  35. sleeplessness
  36. sore mouth or tongue
  37. stomach upset
  38. thick, white vaginal discharge with no odor or with a mild odor
  39. unable to sleep
  40. white patches in the mouth, tongue, or throat

Incidence not known

  1. Difficulty with moving
  2. fear or nervousness
  3. increased sensitivity of the skin to sunlight
  4. muscle pain or stiffness
  5. pain in the joints
  6. redness or other discoloration of the skin
  7. severe sunburn
  8. trouble sitting still

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.