Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Unusual excitement, nervousness, restlessness or irritability, and unusual warmth, dryness, and flushing of skin are more likely to occur in children, who are usually more sensitive to the effects of atropine and hyoscyamine (contained in this combination medicine). Also, when atropine and hyoscyamine are given to children during hot weather, a rapid increase in body temperature may occur. In infants and children, especially those with spastic paralysis or brain damage, this medicine may be more likely to cause severe side effects.

Geriatric

Confusion or memory loss, constipation, difficult urination, excitement, agitation, drowsiness, or dryness of mouth may be more likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of atropine and hyoscyamine. Also, this combination medicine may cause eye pain in patients who have untreated glaucoma.

Breastfeeding

Benzoic Acid

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Methylene Blue

Methenamine

Atropine

Hyoscyamine

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acetazolamide
  • Ambenonium
  • Amitriptyline
  • Amoxapine
  • Amphetamine
  • Atomoxetine
  • Benzphetamine
  • Bupropion
  • Carbamazepine
  • Carbidopa
  • Carbinoxamine
  • Clomipramine
  • Codeine
  • Cyclobenzaprine
  • Desipramine
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Doxepin
  • Doxylamine
  • Duloxetine
  • Entacapone
  • Fenfluramine
  • Fluoxetine
  • Fluvoxamine
  • Hydroxytryptophan
  • Imipramine
  • Isocarboxazid
  • Levodopa
  • Levomilnacipran
  • Linezolid
  • Lisdexamfetamine
  • Mafenide
  • Maprotiline
  • Meperidine
  • Methamphetamine
  • Methylphenidate
  • Milnacipran
  • Mirtazapine
  • Nortriptyline
  • Ozanimod
  • Paroxetine
  • Phenelzine
  • Phentermine
  • Potassium Citrate
  • Protriptyline
  • Pseudoephedrine
  • Rizatriptan
  • Safinamide
  • Selegiline
  • Serdexmethylphenidate
  • Sertraline
  • Silver Sulfadiazine
  • Solriamfetol
  • Sulfabenzamide
  • Sulfacetamide
  • Sulfacytine
  • Sulfadiazine
  • Sulfamerazine
  • Sulfamethazine
  • Sulfamethoxazole
  • Sulfanilamide
  • Sulfapyridine
  • Sulfasalazine
  • Sulfathiazole
  • Sulfisoxazole
  • Sumatriptan
  • Tapentadol
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Trimipramine
  • Tryptophan
  • Vilazodone
  • Viloxazine
  • Vortioxetine
  • Zolmitriptan
  • Zonisamide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Albuterol
  • Alfentanil
  • Almotriptan
  • Alprazolam
  • Amantadine
  • Amifampridine
  • Amineptine
  • Amitriptylinoxide
  • Amtolmetin Guacil
  • Anileridine
  • Atropine
  • Balsalazide
  • Benzhydrocodone
  • Bismuth Subsalicylate
  • Bromazepam
  • Bromfenac
  • Brompheniramine
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Buspirone
  • Butalbital
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Celecoxib
  • Cetirizine
  • Chlorpheniramine
  • Choline Magnesium Trisalicylate
  • Choline Salicylate
  • Clobazam
  • Clonazepam
  • Clonixin
  • Clozapine
  • Cocaine
  • Codeine
  • Daridorexant
  • Dexibuprofen
  • Dexketoprofen
  • Dexmedetomidine
  • Dextromethorphan
  • Diacetylmorphine
  • Dibenzepin
  • Diclofenac
  • Difenoxin
  • Diflunisal
  • Dihydrocodeine
  • Diphenoxylate
  • Dipyrone
  • Dolasetron
  • Donepezil
  • Droxicam
  • Eletriptan
  • Epinephrine
  • Esketamine
  • Ethylmorphine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Flibanserin
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Formoterol
  • Frovatriptan
  • Furazolidone
  • Gabapentin
  • Gabapentin Enacarbil
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Granisetron
  • Hydrocodone
  • Hydromorphone
  • Indomethacin
  • Iobenguane I 123
  • Iobenguane I 131
  • Iproniazid
  • Ketamine
  • Ketobemidone
  • Ketoprofen
  • Lacosamide
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levorphanol
  • Lithium
  • Lofepramine
  • Lofexidine
  • Lorcaserin
  • Lornoxicam
  • Loxapine
  • Loxoprofen
  • Lumiracoxib
  • Macimorelin
  • Magnesium Oxybate
  • Magnesium Salicylate
  • Meclofenamate
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Mesalamine
  • Metaxalone
  • Methacholine
  • Methadone
  • Metoclopramide
  • Midodrine
  • Moclobemide
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Nalbuphine
  • Naproxen
  • Naratriptan
  • Nefazodone
  • Nepafenac
  • Nialamide
  • Nicomorphine
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Norepinephrine
  • Olanzapine
  • Olsalazine
  • Ondansetron
  • Opipramol
  • Opium
  • Opium Alkaloids
  • Oxycodone
  • Oxymetazoline
  • Oxymorphone
  • Oxyphenbutazone
  • Palonosetron
  • Papaveretum
  • Parecoxib
  • Paregoric
  • Pentazocine
  • Periciazine
  • Phenobarbital
  • Phenylbutazone
  • Piketoprofen
  • Piritramide
  • Piroxicam
  • Potassium Oxybate
  • Pregabalin
  • Primidone
  • Procarbazine
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quetiapine
  • Rasagiline
  • Remifentanil
  • Remimazolam
  • Revefenacin
  • Rofecoxib
  • Ropeginterferon Alfa-2b-njft
  • Salicylamide
  • Salicylic Acid
  • Salsalate
  • Scopolamine
  • Secretin Human
  • Sibutramine
  • Sodium Oxybate
  • Sodium Salicylate
  • St John's Wort
  • Sufentanil
  • Sulfasalazine
  • Sulindac
  • Tapentadol
  • Tenoxicam
  • Tianeptine
  • Tiaprofenic Acid
  • Tilidine
  • Tiotropium
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Trolamine Salicylate
  • Valbenazine
  • Valdecoxib
  • Vilanterol
  • Ziprasidone
  • Zolpidem
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Arbutamine
  • Chlorpropamide
  • Glimepiride
  • Glipizide
  • Glyburide
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Metformin
  • Nateglinide
  • Repaglinide
  • Tolazamide
  • Tolbutamide

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems (severe)—This combination medicine may increase heart rate, which would make bleeding problems worse
  • Brain damage (in children)—May increase the central nervous system (CNS) effects of this combination medicine
  • Colitis (severe) or
  • Dryness of mouth (severe or continuing) or
  • Enlarged prostate or
  • Fever or
  • Glaucoma or
  • Heart disease or
  • Hernia (hiatal) or
  • High blood pressure or
  • Intestinal blockage or other intestinal or stomach problems or
  • Lung disease or
  • Myasthenia gravis or
  • Toxemia of pregnancy or
  • Urinary tract blockage or difficult urination—This combination medicine may make these conditions worse
  • Dehydration or
  • Kidney disease or
  • Liver disease—Higher levels of medicine may result and increase the risk of side effects
  • Overactive thyroid—May increase the heart rate