Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (18 years and older)

Note: A suggested daily intake or tolerable upper intake for arginine is lacking. The therapeutic dosage (maximum dose considered to be safe) is 400-6,000 milligrams.

For altitude sickness, four grams in 200 milliliters of fruit punch three times daily has been taken by mouth while ascending to altitude (24 hours) and while at altitude (for 24 hours).

For asthma, a single dose of 50 milligrams of L-arginine per kilogram of body weight has been taken by mouth.

For breast cancer, 30 grams daily for three days has been taken by mouth.

For burns, 15 grams of L-arginine has been taken by mouth daily (duration unknown).

As a chemotherapy add-on, 30 grams has been taken by mouth daily for three days.

For chest pain, L-arginine (dose and duration unknown) has been taken by mouth.

For cognitive function, 1.6 grams of L-arginine has been taken by mouth daily for three months.

For coronary artery disease (CAD), up to nine grams of arginine has been taken by mouth daily in divided doses for three days to six months. 15 grams of L-arginine has been taken by mouth daily in addition to Cardiket™ (isosorbide dinitrate) for 10 days. A dose of 3.2 grams has been taken by mouth twice daily for six months. Three grams of L-arginine has been taken by mouth three times daily for the first three days, followed by nine grams on day four. People with Prinzmetal's angina pectoris took 9.26 grams by mouth daily for an unknown duration.

For diabetes (type 2), 3 grams of L-arginine has been taken by mouth three times daily. 3 grams of L-arginine in 10 milliliters of saline has been infused as a single dose. 30 grams has been given intravenously as a one-time dose and 0.1 grams per kilogram of body weight has also been intravenously given as a one-time dose.

For diabetic complications (peripheral neuropathy), 3 grams of L-arginine has been taken by mouth three times. A cream containing 4 milligrams of L-arginine per square centimeter has been applied to the feet in the morning and evening daily for two weeks.

For erectile dysfunction, 5 grams of L-arginine has been taken by mouth daily for six weeks.

For exercise performance, a single dose of 6 grams of L-arginine in a 500-milliliter beverage has been taken by mouth. Six grams of L-arginine in Gatorade® has been taken by mouth twice daily for 28 days, as have 6 grams of L-arginine daily with meals for 14 days and 14.2 grams of L-arginine daily for six months.

For heart disease, 3-12.6 grams of L-arginine has been taken by mouth daily for up to six weeks. 1-7 grams has been taken by mouth 2-3 times daily for up to six weeks for various disease states and risk factors related to heart disease. 5 milligrams per kilogram of body weight per minute has been infused intravenously for 20 minutes prior to exercise testing. An infusion of 60 grams of L-arginine over 20 minutes has also been used.

For heart failure, 5.6-12.6 grams of L-arginine has been taken by mouth daily for up to six weeks. Doses of 15 grams have been taken by mouth daily for five days. A dose of 2 grams of L-arginine has been taken by mouth three times daily for three months. 20 milligrams of L-arginine have been given intravenously as a one-time dose and 500 milligrams per kilogram of bodyweight has also been given intravenously as a one-time dose.

For high blood pressure (cardiac and pulmonary), 12 grams of L-arginine has been taken by mouth daily for four weeks. A single dose of two grams of L-arginine as an adjunct to 60 milligrams of isosorbide mononitrate has been taken by mouth. A dose of 0.5-1.5 grams of L-arginine per 10 kilograms of body weight has been taken by mouth for one week. Doses of 4-24 grams have been taken by mouth daily for 2-24 weeks. Two grams of L-arginine has been taken three times daily for six weeks.

For hyperlipidemia (high cholesterol), 7 grams of L-arginine has been taken by mouth three times daily for four weeks.

As an immunomodulator, L-arginine (dose unknown) has been taken by mouth for 60 days.

For infertility, up to 4 grams or 16 grams of L-arginine has been taken by mouth daily for unknown duration.

For interstitial cystitis, 1.5-2.4 grams of L-arginine has been taken by mouth daily for up to three months.

For intrauterine growth retardation, 3 grams has been taken by mouth daily for 20 days.

For MELAS syndrome, L-arginine (dose unknown) has been taken by mouth for up to two years. Intravenous L-arginine (dose and duration unknown) has been used.

For myocardial infarction (heart attack), 3 grams of L-arginine has been taken by mouth three times daily for up to six months. A dosage of 3 grams of L-arginine has been taken by mouth three times daily for 30 days.

For peripheral vascular disease and claudication, 24 grams of L-arginine has been taken by mouth daily for eight weeks, and 3.3 grams of L-arginine has been taken by mouth twice daily. Eight grams of L-arginine has been given intravenously twice daily for three weeks. Doses of 3-6 grams of L-arginine have been taken by mouth daily for one day to six weeks.

For pre-eclampsia (high blood pressure in pregnancy), 3 grams of L-arginine has been taken by mouth daily, in addition to standard therapy, for three weeks. Three grams of L-arginine has been taken by mouth every six hours, or intravenously (10 grams every eight hours) if the L-arginine taken by mouth was not tolerated, from diagnosis until day 10 postpartum. A dose of 4 grams of L-arginine has been taken by mouth daily for 10-12 weeks. A single intravenous infusion of L-arginine (20 grams per 500 milliliters) has been used. Five consecutive single daily infusions of L-arginine (20 grams per 500 milliliters), followed by 4 grams of arginine taken by mouth daily for two weeks, have been used. A dosage of L-arginine (20 grams per 500 milliliters) has been infused over two hours for four consecutive days.

For Raynaud's phenomenon, 8 grams of L-arginine has been taken by mouth daily for 28 days.

For respiratory infections, L-arginine (dose unknown) has been taken by mouth for 60 days.

For transplants, 0.1 gram of L-arginine per kilogram of body weight has been taken by mouth daily for six weeks, and 6 grams has been taken by mouth twice daily for six weeks. Also, 0.5 grams of L-arginine per kilogram has been given intravenously over 60 minutes, two hours prior to surgery.

For wound healing, 30 grams of arginine aspartate, containing 17 grams of arginine, has been taken by mouth in three divided doses for two weeks. A dose of 36.2 grams of L-arginine HCl has been taken by mouth daily for five days.

For anal fissures, a gel containing 400 milligrams of L-arginine per milliliter has been applied to the skin five times daily for at least 12 weeks.

For adrenoleukodystrophy (ALD), arginine butyrate (dose unknown) has been infused intravenously for over four months.

For autonomic failure, a single dose of 0.5 grams of L-arginine per kilogram of body weight has been given intravenously.

For circulation problems, a single dose of 30 grams of L-arginine has been intravenously given over 60 minutes.

For cyclosporine toxicity, graded doses of L-arginine (50, 100, or 150 milligrams per kilogram of body weight) have been delivered intravenously over three consecutive hours.

For growth hormone reserve test/pituitary disorder diagnosis, 30 grams of arginine hydrochloride has been injected.

For heart protection during coronary artery bypass grafting (CABG), a single venous infusion of 10% arginine hydrochloride (30 grams) over 15 minutes has been used. A dose of 7.5 grams of L-arginine in 500 milliliters of cardioplegic solution has been given intravenously.

For inborn errors of urea synthesis, doses of FDA-approved prescription parenteral arginine hydrochloride generally depend on specific institutional dosing guidelines.

For kidney protection during angiography, 330 milligrams of L-arginine per kilogram of body weight has been given intravenously over 20-30 minutes.

For malaria, 3, 6, and 12 grams of intravenous L-arginine have been infused over 30 minutes.

For the prevention of restenosis (recurrence of blood vessel narrowing) after coronary angioplasty (PTCA), 200 milligrams of L-arginine per kilogram of bodyweight were given by intravenous infusions over two hours prior to and during coronary surgery and 500 milligrams was given into the heart immediately before stent placement, followed by 6 grams of L-arginine by mouth daily for two weeks; however, there was a lack of benefit on scar tissue formation after coronary stenting. L-arginine has also been given through a dispatch catheter as 600 milligrams per six milliliters over 15 minutes after stent placement.

For sickle cell anemia, total daily doses of arginine butyrate of 500 milligrams per kilogram of bodyweight have been given intravenously for five days weekly for 12 weeks.

Children (younger than 18 years)

Arginine supplements are not suggested in children, because there is not enough scientific information available and because of potential side effects.

For birth outcomes, 1.5 millimoles of L-arginine per kilogram of bodyweight has been given by mouth daily with feeds and parenteral nutrition over the first 28 days in premature infants. In addition, daily doses of 1.5 millimoles per kilogram of bodyweight have been given to infants at risk for necrotizing enterocolitis (death of intestinal tissue).

For MELAS syndrome, 0.4 milligrams of L-arginine per kilogram of bodyweight have been used daily for an unknown duration in a 12 year-old child with MELAS syndrome. Intravenous administration of L-arginine (dose and duration unknown) followed by oral administration (dose and duration unknown) has also been used in a 15 year-old boy with MELAS syndrome.

For growth hormone reserve test and pituitary disorder diagnosis, injections of 0.5 grams of arginine hydrochloride per kilogram of bodyweight are commonly used.

For transplants, 0.1 grams of L-arginine per kilogram of bodyweight has been used daily for six weeks; however, improvement in kidney function was lacking.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com