Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Eraxis

Descriptions


Anidulafungin is an antifungal medicine. It is used to treat fungal infections in the blood, abdomen or stomach, and esophagus (part of your throat where food passes from the pharynx to the stomach).

This medicine is to be given only by or under the direct supervision of a doctor.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of anidulafungin injection in children 16 years of age and younger. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anidulafungin injection in the elderly.

Pregnancy

Information about this anidulafungin-intravenous-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergies to other echinocandin antifungal drugs (e.g., caspofungin [Cancidas®], micafungin [Mycamine®])—Should not be used in patients with this condition.
  • Liver problems—Use with caution. May make this condition worse.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in a vein and given over 45 minutes to 3 hours, depending on your dose

Precautions

It is very important that your doctor check you closely while you are receiving this medicine. This is to make sure the medicine has worked properly. Blood tests may be needed to check for unwanted effects.

Tell your doctor right away if you have any symptoms of liver problems including dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, or yellow skin or eyes.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

It is important to tell your doctor if you are pregnant, planning to become pregnant.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  1. Black, tarry stools
  2. chills
  3. cough
  4. decreased urine
  5. dry mouth
  6. fever
  7. increased thirst
  8. irregular heartbeat
  9. loss of appetite
  10. lower back or side pain
  11. mood or mental changes
  12. muscle pain or cramps
  13. nausea or vomiting
  14. numbness or tingling in the hands, feet or lips
  15. painful or difficult urination
  16. pale skin
  17. seizures
  18. shortness of breath
  19. sore throat
  20. sores, ulcers, or white spots on the lips or in the mouth
  21. unusual bleeding or bruising
  22. unusual tiredness or weakness

Rare

  1. Abdominal or stomach pain
  2. back pain
  3. bleeding gums
  4. blood in the urine or stools
  5. bloody stools
  6. bluish color of skin
  7. blurred or loss of vision
  8. changes in skin color
  9. chest pain
  10. chest tightness
  11. clay-colored stools
  12. constipation
  13. dark urine
  14. depression
  15. diarrhea
  16. dizziness
  17. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  18. drowsiness
  19. extra heartbeats
  20. fainting
  21. fast heartbeat
  22. flushed, dry skin
  23. flushing
  24. fruit-like breath odor
  25. headache
  26. hives or welts
  27. incoherent speech
  28. increased hunger
  29. increased urination
  30. irregular fast heartbeat
  31. irritability
  32. itching
  33. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  34. light-colored stools
  35. metallic taste
  36. muscle spasms (tetany) or twitching
  37. muscle weakness
  38. nervousness
  39. pain, redness, or swelling in the arm or leg
  40. pain, tenderness, and swelling of foot or leg
  41. pinpoint red spots on the skin
  42. pounding in the ears
  43. redness of the skin
  44. restlessness
  45. skin rash
  46. slow heartbeat
  47. sore mouth or tongue
  48. sweating
  49. swelling of the feet or lower legs
  50. swollen glands
  51. trembling
  52. trouble breathing
  53. unexplained weight loss
  54. unpleasant breath odor
  55. unusually warm skin
  56. vomiting of blood
  57. weakness
  58. weight loss
  59. white patches in the mouth or throat or on the tongue
  60. white patches with diaper rash
  61. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  1. Acid or sour stomach
  2. belching
  3. bloating or swelling of the face, arms, hands, lower legs, or feet
  4. disturbed color perception
  5. double vision
  6. eye pain
  7. feeling of warmth
  8. feeling unusually cold
  9. halos around light
  10. indigestion
  11. loss of bowel control
  12. night blindness
  13. over bright appearance of lights
  14. rapid weight gain
  15. redness of the face, neck, arms, and occasionally, upper chest
  16. shivering
  17. stomach discomfort or upset
  18. tingling of the hands or feet
  19. tunnel vision
  20. unusual weight gain or loss
  21. upper stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.