Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Asendin

Descriptions


Amoxapine is used to treat the symptoms of depression. It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain. This medicine is a tricyclic antidepressant (TCA).

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amoxapine in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amoxapine in the elderly. However, elderly patients are more likely to have unwanted effects (e.g., movement disorders, unusual drowsiness) or age-related kidney or liver problems, which may require an adjustment in the dose for patients receiving amoxapine.

Pregnancy

Information about this amoxapine-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cisapride
  • Clorgyline
  • Dronedarone
  • Grepafloxacin
  • Isocarboxazid
  • Levomethadyl
  • Linezolid
  • Mesoridazine
  • Methylene Blue
  • Metoclopramide
  • Moclobemide
  • Phenelzine
  • Pimozide
  • Ranolazine
  • Selegiline
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Alfuzosin
  • Almotriptan
  • Amiodarone
  • Amitriptyline
  • Amprenavir
  • Apomorphine
  • Aprindine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bretylium
  • Bromocriptine
  • Brompheniramine
  • Buspirone
  • Chloral Hydrate
  • Chloroquine
  • Chlorpheniramine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clomipramine
  • Clonidine
  • Clozapine
  • Cocaine
  • Cyclobenzaprine
  • Dasatinib
  • Desipramine
  • Desvenlafaxine
  • Dextromethorphan
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxepin
  • Droperidol
  • Eletriptan
  • Enflurane
  • Epinephrine
  • Erythromycin
  • Escitalopram
  • Etilefrine
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluvoxamine
  • Foscarnet
  • Frovatriptan
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Halothane
  • Hydroxytryptophan
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indacaterol
  • Iobenguane I 123
  • Iproniazid
  • Isoflurane
  • Isradipine
  • Lapatinib
  • Levalbuterol
  • Levofloxacin
  • Levomilnacipran
  • Levothyroxine
  • Lidoflazine
  • Lithium
  • Lopinavir
  • Lorcainide
  • Lorcaserin
  • Lumefantrine
  • Mefloquine
  • Meperidine
  • Methadone
  • Methoxamine
  • Midodrine
  • Milnacipran
  • Moricizine
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Naratriptan
  • Nefazodone
  • Nefopam
  • Nilotinib
  • Norepinephrine
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olodaterol
  • Ondansetron
  • Oxilofrine
  • Oxymorphone
  • Paliperidone
  • Pargyline
  • Pazopanib
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Phenylephrine
  • Posaconazole
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quinidine
  • Quinine
  • Rasagiline
  • Saquinavir
  • Sematilide
  • Sertraline
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sumatriptan
  • Sunitinib
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Toremifene
  • Tramadol
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Tryptophan
  • Umeclidinium
  • Vardenafil
  • Vasopressin
  • Venlafaxine
  • Vilanterol
  • Voriconazole
  • Vortioxetine
  • Ziprasidone
  • Zolmitriptan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Arbutamine
  • Atomoxetine
  • Cannabis
  • Carbamazepine
  • Dicumarol
  • Paroxetine
  • Phenprocoumon
  • S-Adenosylmethionine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bipolar disorder (mood disorder with alternating episodes of mania and depression), or risk of or
  • Heart attack, recent—Should not be used in patients with these conditions.
  • Glaucoma, history of or
  • Heart disease or
  • Schizophrenia or
  • Seizures, history of or
  • Urinary retention (trouble urinating), history of—Use with caution. May make these conditions worse.

Proper Use

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For depression:
      • Adults—At first, 50 milligrams (mg) two or three times per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 300 mg per day unless you are in a hospital. Some hospitalized patients may need higher doses. If you are taking this medicine once a day, it is best to take it at bedtime.
      • Older Adults—At first, 25 milligrams (mg) two or three times per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 300 mg per day unless you are in a hospital. Some hospitalized patients may need higher doses. If you are taking this medicine once a day, it is best to take it at bedtime.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects.

Amoxapine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor or your child's doctor right away.

Do not take amoxapine if you have taken a monoamine oxidase (MAO) inhibitor (isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®, or tranylcypromine [Parnate®]) in the past two weeks. Do not start taking a MAO inhibitor within two weeks of stopping amoxapine. If you do, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, or severe convulsions.

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while taking this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Check with your doctor right away if you are having convulsions (seizures); difficulty with breathing; a fast heartbeat; high fever; high or low blood pressure; increased sweating; loss of bladder control; severe muscle stiffness; unusually pale skin; or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

Do not stop taking this medicine without first checking with your doctor . Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as headache, nausea, or a general feeling of discomfort or illness.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that cause drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

This medicine may cause some people to become drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are drowsy or not alert.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

  1. Excitement
  2. fast, irregular, pounding, or racing heartbeat or pulse
  3. fear or nervousness
  4. mood or mental changes
  5. nightmares
  6. restlessness
  7. shakiness and unsteady walk
  8. shakiness in legs, arms, hands, or feet
  9. sleeplessness
  10. swelling
  11. trouble sleeping
  12. unable to sleep
  13. unsteadiness, trembling, or other problems with muscle control or coordination

Rare

  1. Abdominal or stomach pain
  2. actions that are out of control
  3. black, tarry stools
  4. bleeding gums
  5. bloating
  6. blood in urine or stools
  7. blurred vision
  8. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  9. chest pain or discomfort
  10. chills
  11. clay-colored stools
  12. confusion
  13. confusion about identity, place, and time
  14. constipation
  15. continuing ringing or buzzing or other unexplained noise in ears
  16. convulsions
  17. cough or hoarseness
  18. dark urine
  19. decrease in frequency of urination
  20. decrease in urine volume
  21. difficulty in breathing
  22. difficulty in passing urine (dribbling)
  23. difficulty in speaking
  24. disturbed concentration
  25. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  26. double vision
  27. drooling
  28. extremely high fever or body temperature
  29. false beliefs that cannot be changed by facts
  30. fast, weak heartbeat
  31. fever with or without chills
  32. general feeling of tiredness or weakness
  33. headache
  34. hearing loss
  35. high fever
  36. high or low blood pressure
  37. hives or welts
  38. inability to move arms, legs, or facial muscles
  39. inability to speak
  40. increased need to urinate
  41. increased sweating
  42. indigestion
  43. irritability
  44. itching
  45. lack of coordination
  46. light-colored stools
  47. lip smacking or puckering
  48. loss of appetite
  49. loss of bladder control
  50. lower back or side pain
  51. muscle cramps
  52. muscle spasm or jerking of all extremities
  53. muscle trembling, jerking, or stiffness
  54. nausea and vomiting
  55. nervousness
  56. numbness
  57. pain or discomfort in arms, jaw, back, or neck
  58. painful or difficult urination
  59. pains in stomach, side, or abdomen, possibly radiating to the back
  60. pale, clammy skin
  61. passing urine more often
  62. pinpoint red spots on skin
  63. pounding in the ears
  64. puffing of cheeks
  65. rapid or worm-like movements of tongue
  66. redness of skin
  67. seeing, hearing, or feeling things that are not there
  68. severe muscle stiffness
  69. shortness of breath
  70. shuffling walk
  71. skin rash
  72. slow speech
  73. sore throat
  74. sores, ulcers, or white spots on lips or in mouth
  75. stiffness of limbs
  76. sudden loss of consciousness
  77. sweating
  78. swollen glands
  79. talking, feeling, and acting with excitement
  80. testicular swelling
  81. thirst
  82. trouble in holding or releasing urine
  83. twisting movements of body
  84. uncontrolled chewing movements
  85. uncontrolled movements, especially of face, neck, and back
  86. unpleasant breath odor
  87. unusual bleeding or bruising
  88. unusually pale skin
  89. upper right abdominal pain
  90. vomiting of blood
  91. yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Change in consciousness
  2. drowsiness
  3. epileptic seizure that will not stop
  4. fatigue
  5. increased blood pressure
  6. increased thirst
  7. loss of consciousness
  8. swelling of face, fingers, or lower legs
  9. total body jerking
  10. troubled breathing
  11. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Dry mouth

Less common

  1. Increased appetite
  2. increased flow of breast milk

Rare

  1. Agitation
  2. breast enlargement
  3. change in taste bad unusual or unpleasant (after)taste
  4. decreased interest in sexual intercourse
  5. depression
  6. excess air or gas in stomach or intestines
  7. full feeling
  8. hair loss, thinning of hair
  9. heartburn
  10. inability to have or keep an erection
  11. increased in sexual ability, desire, drive, or performance
  12. increased interest in sexual intercourse
  13. increased sensitivity of skin to sunlight
  14. loss in sexual ability, desire, drive, or performance
  15. menstrual changes
  16. nasal stuffiness
  17. painful ejaculation
  18. passing gas
  19. rapid weight gain
  20. redness or other discoloration of skin
  21. seizures
  22. severe sunburn
  23. stupor
  24. swollen, painful, or tender lymph glands on side of face or neck
  25. tearing of the eyes
  26. unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.