Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Cordarone IV

Descriptions


Amiodarone injection is used to correct life-threatening heart rhythm problems called ventricular arrhythmias. This medicine is used in patients who have already been treated with other medicines that did not work.

Amiodarone injection belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep the heart rhythm normal.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amiodarone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amiodarone injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving amiodarone injection.

Pregnancy

Information about this amiodarone-intravenous-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Bepridil
  • Cisapride
  • Dronedarone
  • Fingolimod
  • Fluconazole
  • Grepafloxacin
  • Indinavir
  • Ketoconazole
  • Levomethadyl
  • Mesoridazine
  • Nelfinavir
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Ritonavir
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tipranavir
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Acebutolol
  • Acecainide
  • Afatinib
  • Alprenolol
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amlodipine
  • Amoxapine
  • Amprenavir
  • Apomorphine
  • Aprepitant
  • Aprindine
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atazanavir
  • Atenolol
  • Azimilide
  • Azithromycin
  • Bedaquiline
  • Betaxolol
  • Bevantolol
  • Bicalutamide
  • Bisoprolol
  • Boceprevir
  • Bosutinib
  • Bretylium
  • Bucindolol
  • Carbamazepine
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Ceritinib
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cilostazol
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Dabigatran Etexilate
  • Dabrafenib
  • Darunavir
  • Dasatinib
  • Deferasirox
  • Delavirdine
  • Desipramine
  • Dibenzepin
  • Digoxin
  • Dilevalol
  • Diltiazem
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Ebastine
  • Eletriptan
  • Enflurane
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Esmolol
  • Etravirine
  • Everolimus
  • Felodipine
  • Fentanyl
  • Flecainide
  • Flunarizine
  • Fluoxetine
  • Fluvoxamine
  • Formoterol
  • Fosamprenavir
  • Fosaprepitant
  • Foscarnet
  • Gallopamil
  • Gatifloxacin
  • Gemifloxacin
  • Ginkgo Biloba
  • Goldenseal
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imatinib
  • Imipramine
  • Iohexol
  • Isoflurane
  • Isoniazid
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Labetalol
  • Lacidipine
  • Lapatinib
  • Lercanidipine
  • Levobunolol
  • Levofloxacin
  • Lidocaine
  • Lidoflazine
  • Lopinavir
  • Loratadine
  • Lorcainide
  • Lovastatin
  • Lumefantrine
  • Manidipine
  • Mefloquine
  • Mepindolol
  • Methadone
  • Metipranolol
  • Metoprolol
  • Metronidazole
  • Mibefradil
  • Miconazole
  • Mifepristone
  • Mitotane
  • Mizolastine
  • Moricizine
  • Moxifloxacin
  • Nadolol
  • Nebivolol
  • Nefazodone
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nilvadipine
  • Nisoldipine
  • Nitrendipine
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Ospemifene
  • Oxprenolol
  • Oxycodone
  • Paliperidone
  • Pasireotide
  • Pazopanib
  • Penbutolol
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Perhexiline
  • Perphenazine
  • Pindolol
  • Pixantrone
  • Pomalidomide
  • Pranidipine
  • Prilocaine
  • Primidone
  • Probucol
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propranolol
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranitidine
  • Ranolazine
  • Regorafenib
  • Rifampin
  • Risperidone
  • Romidepsin
  • Salmeterol
  • Sematilide
  • Sertindole
  • Sevoflurane
  • Siltuximab
  • Simeprevir
  • Simvastatin
  • Sirolimus
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • St John's Wort
  • Sulfamethoxazole
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Talinolol
  • Tedisamil
  • Telaprevir
  • Telithromycin
  • Tertatolol
  • Tetrabenazine
  • Ticagrelor
  • Timolol
  • Tizanidine
  • Toremifene
  • Trabectedin
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Vasopressin
  • Vemurafenib
  • Verapamil
  • Vilanterol
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Voriconazole
  • Warfarin
  • Zileuton
  • Ziprasidone
  • Zolmitriptan
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abarelix
  • Acenocoumarol
  • Atorvastatin
  • Cholestyramine
  • Clonazepam
  • Clopidogrel
  • Cyclosporine
  • Dicumarol
  • Digitoxin
  • Flecainide
  • Fosphenytoin
  • Methotrexate
  • Nevirapine
  • Phenytoin
  • Procainamide
  • Rifapentine
  • Rosuvastatin
  • Theophylline
  • Tolterodine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • AV block (type of abnormal heart rhythm), with no pacemaker or
  • Bradycardia (slow heartbeat) or
  • Cardiogenic shock or
  • Sick sinus syndrome (type of abnormal heart rhythm), with no pacemaker—Should not be used in patients with these conditions.
  • Eye or vision problems or
  • Heart rhythm problems (e.g., QT prolongation) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypotension (low blood pressure) or
  • Lung disease or other breathing problems or
  • Thyroid problems—Use with caution. May make these conditions worse.

Proper Use

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions

It is very important that your doctor check your progress while you receive this medicine to make sure that it is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. These symptoms are more likely to occur when you begin using this medicine, or when the dose is increased.

Liver problems may occur while you are using this medicine. Check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

This medicine can cause changes in your heart rhythm, such as a condition called QT prolongation. It may cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Tell your doctor right away if you are having shortness of breath, chest tightness, wheezing, or any type of breathing problem while being treated with this medicine.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Grapefruits and grapefruit juice may increase the side effects from amiodarone injection by increasing the amount of this medicine in your body. You should not eat grapefruit or drink grapefruit juice while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Blurred vision
  2. confusion
  3. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  4. sweating
  5. unusual tiredness or weakness

Less common

  1. Black, tarry stools
  2. bleeding gums
  3. blistering, peeling, or loosening of the skin
  4. blood in the urine or stools
  5. chest pain or discomfort
  6. chills
  7. cold, clammy skin
  8. cough
  9. decreased urine output
  10. diarrhea
  11. difficulty with breathing
  12. dilated neck veins
  13. dizziness
  14. extreme fatigue
  15. fainting
  16. fast, pounding, or irregular heartbeat or pulse
  17. fast, weak pulse
  18. fever
  19. irregular heartbeat recurrent
  20. itching
  21. joint or muscle pain
  22. lightheadedness, dizziness, or fainting
  23. no blood pressure or pulse
  24. pinpoint red spots on the skin
  25. red, irritated eyes
  26. red skin lesions, often with a purple center
  27. shortness of breath
  28. slow or irregular heartbeat
  29. sore throat
  30. sores, ulcers, or white spots in the mouth or on the lips
  31. stopping of the heart
  32. swelling of the face, fingers, feet, or lower legs
  33. tightness in the chest
  34. troubled breathing
  35. unconsciousness
  36. unusual bleeding or bruising
  37. weight gain
  38. wheezing

Incidence not known

  1. Abdominal or stomach pain
  2. agitation
  3. back, leg, or stomach pains
  4. bleeding gums
  5. bloating
  6. blurred or double vision
  7. clay-colored stools
  8. coma
  9. confusion about identity, place, and time
  10. cough or hoarseness
  11. coughing or spitting up blood
  12. cracks in the skin
  13. dark-colored urine
  14. decreased frequency or amount of urine
  15. decreased urine output
  16. depression
  17. difficulty swallowing
  18. eye pain
  19. fever with or without chills
  20. general body swelling
  21. general feeling of tiredness or weakness
  22. headache
  23. high fever
  24. hives
  25. holding false beliefs that cannot be changed by fact
  26. hostility
  27. increased blood pressure
  28. increased thirst
  29. indigestion
  30. inflamed tissue from infection
  31. irritability
  32. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  33. lethargy
  34. light-colored stools
  35. loss of appetite
  36. loss of heat from the body
  37. lower back or side pain
  38. muscle cramps or spasms
  39. muscle pain or stiffness
  40. muscle twitching
  41. muscular pain, tenderness, wasting, or weakness
  42. noisy breathing
  43. nosebleeds
  44. painful or difficult urination
  45. pains in the stomach, side, or abdomen, possibly radiating to the back
  46. pale skin
  47. persistent non-healing sore
  48. pink growth
  49. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  50. rapid weight gain
  51. rash
  52. red, swollen skin
  53. reddish patch or irritated area
  54. redness, soreness, or itching skin
  55. scaly skin
  56. seeing, hearing, or feeling things that are not there
  57. seizures
  58. severe headache
  59. shiny bump
  60. sores, welting, or blisters
  61. stupor
  62. swollen or painful glands
  63. unexplained bleeding or bruising
  64. unpleasant breath odor
  65. unusual excitement, nervousness, or restlessness
  66. upper right abdominal pain
  67. vomiting
  68. vomiting of blood
  69. weakness
  70. white, yellow, or waxy scar-like area
  71. yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.