Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Aloprim

Descriptions


Allopurinol injection is used to prevent or treat high uric acid levels in the blood that may be caused by cancer medicines. Allopurinol is a xanthine oxidase inhibitor that works by causing less uric acid to be produced by the body.

This medicine is to be given only by or under the direct supervision of a doctor.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of allopurinol injection in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of allopurinol injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving allopurinol injection.

Pregnancy

Information about this allopurinol-intravenous-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Didanosine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Azathioprine
  • Captopril
  • Cyclophosphamide
  • Enalapril
  • Enalaprilat
  • Mercaptopurine
  • Pegloticase
  • Tegafur

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine
  • Phenprocoumon
  • Vidarabine
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bone marrow problems or
  • Liver disease—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you or your child this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Drink plenty of liquids while you are receiving this medicine to help prevent kidney stones. Check with your doctor about the amount of liquid you or your child should drink each day.

Precautions

It is very important that your doctor check you or your child closely while you are receiving this medicine. This is to make sure that the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

If you or your child develop a skin rash, hives, swelling of the lips or mouth, or any allergic reaction to this medicine, tell your doctor or nurse right away.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause some people to become drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  1. Agitation
  2. coma
  3. confusion
  4. decreased urine output
  5. depression
  6. dizziness
  7. headache
  8. hostility
  9. irritability
  10. lethargy
  11. muscle twitching
  12. nausea
  13. rapid weight gain
  14. seizures
  15. stupor
  16. swelling of the face, ankles, or hands
  17. unusual tiredness or weakness

Rare

  1. Abdominal or stomach pain
  2. black, tarry stools
  3. bladder pain
  4. bleeding gums
  5. blood in the urine or stools
  6. blurred vision
  7. changes in skin color
  8. chest pain
  9. chills
  10. clay-colored stools
  11. cloudy urine
  12. cough or hoarseness
  13. coughing up blood
  14. dark urine
  15. difficult, burning, or painful urination
  16. difficulty with breathing or swallowing
  17. difficulty with speaking
  18. dilated neck veins
  19. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  20. double vision
  21. enlarged abdomen or stomach
  22. extreme fatigue
  23. fainting
  24. fast or slow heartbeat
  25. feeling of warmth
  26. fever
  27. frequent urge to urinate
  28. inability to move the arms, legs, or facial muscles
  29. inability to speak
  30. increased menstrual flow or vaginal bleeding
  31. increased sweating
  32. irregular breathing
  33. irregular heartbeat
  34. itching
  35. joint pain, stiffness, or swelling
  36. lightheadedness
  37. loosening of the fingernails
  38. loss of appetite
  39. loss of strength or energy
  40. lower back or side pain
  41. muscle pain or weakness
  42. nosebleeds
  43. numbness, tingling, pain, or weakness in the hands or feet
  44. pain
  45. pain, tenderness, or swelling of the foot or leg
  46. paralysis
  47. pinpoint red spots on the skin
  48. prolonged bleeding from cuts
  49. rapid, shallow breathing
  50. rash
  51. red or black, tarry stools
  52. red or dark brown urine
  53. redness of the face, neck, arms, and occasionally, upper chest
  54. shortness of breath
  55. slow speech
  56. sore throat
  57. sores, ulcers, or white spots on the lips or in the mouth
  58. sudden shortness of breath or troubled breathing
  59. sweating
  60. swelling of the fingers, feet, or lower legs
  61. swollen glands
  62. tightness in the chest
  63. troubled breathing
  64. unpleasant breath odor
  65. unusual bleeding or bruising
  66. unusual weak feeling
  67. vomiting of blood
  68. weight gain
  69. wheezing
  70. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  1. Diarrhea
  2. drowsiness
  3. indigestion
  4. stomach pain
  5. unusual hair loss

Rare

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  2. body aches or pain
  3. congestion
  4. cracked lips
  5. difficulty with moving
  6. hair loss or thinning of the hair
  7. hives or welts
  8. itching, pain, redness, swelling, tenderness, or warmth on the skin
  9. muscle stiffness
  10. redness of the skin
  11. runny nose
  12. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.