DefinitionBy Mayo Clinic Staff
Zollinger-Ellison syndrome is a rare condition in which one or more tumors form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid. The excess acid then leads to peptic ulcers, as well as to diarrhea and other symptoms.
Zollinger-Ellison syndrome (ZES) is rare. The disease may occur at any time in life, but people are usually diagnosed between ages 20 and 50. Medications to reduce stomach acid and heal the ulcers is the usual treatment for Zollinger-Ellison syndrome.
Oct. 17, 2015
- Greenberger NJ, et al. Zollinger-Ellison syndrome. Current Diagnosis & Treatment: Gastroenterology, Hepatology & Endoscopy. 2nd ed. New York, N.Y.: The McGraw-Hill Companies. http://www.accessmedicine.com. Accessed Aug. 2, 2015.
- Zollinger-Ellison syndrome. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx. Accessed Aug. 2, 2015.
- Cameron JL, et al, eds. Zollinger-Ellison syndrome. In: Current Surgical Therapy. 11th ed. Philadelphia, Pa.; Saunders Elsevier: 2014. http://www.accessmedicine.com. Accessed Aug. 2, 2015.
- Goldfinger SE. Zollinger-Ellison syndrome (gastrinoma): Clinical manifestations and diagnosis. http://www.uptodate.com. Accessed Aug. 2, 2015.
- Krampitz GW, et al. Current management of the Zollinger-Ellison syndrome. Advances in Surgery. 2013;47:59.
- FDA Drug Safety Communication: Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm213206.htm. Accessed Aug. 5, 2015.