X-linked agammaglobulinemia (a-gam-uh-glob-u-lih-NEE-me-uh) — or XLA — is an inherited (genetic) immune system disorder that reduces your ability to fight infections. People with XLA may experience infections of the inner ear, sinuses, respiratory tract, bloodstream and internal organs.

XLA affects males almost exclusively, although females can be genetic carriers of the condition. Diagnosis of XLA often occurs in infancy or early childhood, once it's clear that a child has experienced repeated infections. Sometimes, diagnosis doesn't occur until adulthood.

  • Expertise. Mayo Clinic doctors trained in immune system disorders have expertise in caring for people with XLA and other primary immunodeficiency conditions. The Primary Immunodeficiency Center at Mayo Clinic in Rochester, Minnesota, is a designated Jeffrey Modell Foundation Diagnostic and Research Center. In addition, the Department of Medical Genetics includes clinical geneticists who are physicians certified in primary immunodeficiency conditions.
  • Diagnosis and treatment experience. Mayo Clinic doctors have experience diagnosing and treating people with XLA. Doctors work closely with you to provide the most appropriate care for your or your child's needs, focusing on decreasing the frequency and the severity of your infections. Doctors trained in pediatric immunodeficiency disorders care for children with XLA and other immune system disorders.
  • Genetic counseling. Analysis of your DNA can reveal whether you have the inherited gene that causes XLA. The Department of Medical Genetics can help you understand how a genetically based disorder such as XLA affects you or your child and your family.
  • Research. Mayo Clinic doctors conduct research in XLA and other primary immunodeficiency conditions and conduct clinical trials.

Read more about tests and diagnosis and treatment of primary immunodeficiency disorders.

At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.

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Why Choose Mayo Clinic

What Sets Mayo Clinic Apart

Mayo Clinic doctors diagnose XLA and other primary immunodeficiency disorders.

To diagnose your condition, your doctor will review your family and medical history and conduct a physical examination. Your doctor may order several tests to diagnose XLA.

  • Blood and serum measurement tests. Your doctor may conduct a serum immunoglobulin (Ig) test or other tests to measure the amount of serum immunoglobulin in your body. This will show how well your body can make antibodies to fight off infections. Doctors usually use this test to diagnose XLA.
  • Genetic testing. Your doctor may request a genetic test to confirm the presence of a specific genetic mutation that results in XLA.

Mayo Clinic doctors have experience treating XLA with several options. Doctors will help reduce your infections and help you manage your condition.

Your treatment may include:

  • Immunoglobulin G. You may have immunoglobulin G injections or IVs periodically, which may help boost cells in your immune system and help fight infections.
  • Infection management. Doctors work to recognize and treat your infections as soon as they occur.
  • Medications. Doctors may prescribe antibiotic medications to help treat your condition.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Doctors trained in allergy, asthma and clinical immunology care for adults with XLA at Mayo Clinic in Phoenix/Scottsdale, Arizona.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases care for adults with XLA at Mayo Clinic in Jacksonville, Florida.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases in the Primary Immunodeficiency Center and other areas care for people with XLA at Mayo Clinic in Rochester, Minnesota.

For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.

Doctors trained in pediatric immunodeficiency disorders, pediatrics, and pediatric allergy, immunology and pulmonary medicine care for children with XLA at Mayo Clinic in Rochester, Minnesota.

For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.

See information on patient services at the three Mayo Clinic locations, including transportation options and lodging.

Doctors trained in immune system disorders and other areas conduct basic and clinical research in potential diagnostic tests and treatments, including stem cell transplantation and gene therapy, for X-linked agammaglobulinemia. Staff members in the Primary Immunodeficiency Center at Mayo Clinic in Rochester, Minnesota, conduct research in XLA and other primary immunodeficiency conditions.

See a list of publications by Mayo authors on PubMed, a service of the National Library of Medicine.

March 12, 2015