X-linked agammaglobulinemia (a-gam-uh-glob-u-lih-NEE-me-uh) — or XLA — is an inherited (genetic) immune system disorder that reduces your ability to fight infections. People with XLA may experience infections of the inner ear, sinuses, respiratory tract, bloodstream and internal organs.

XLA affects males almost exclusively, although females can be genetic carriers of the condition. Diagnosis of XLA often occurs in infancy or early childhood, once it's clear that a child has experienced repeated infections. Sometimes, diagnosis doesn't occur until adulthood.

  • Expertise. Mayo Clinic doctors trained in immune system disorders have expertise in caring for people with XLA and other primary immunodeficiency conditions. The Primary Immunodeficiency Center at Mayo Clinic in Minnesota is a designated referral center for the Jeffrey Modell Foundation — a nonprofit organization that promotes and conducts research for primary immunodeficiency disorders.
  • Diagnosis and treatment experience. Mayo Clinic doctors provide timely diagnosis and treatment for people with XLA. Doctors work closely with you to provide the most appropriate care for your or your child's needs, focusing on decreasing the frequency and the severity of your infections. Doctors trained in pediatric immunodeficiency disorders care for children with XLA and other immune system disorders.
  • Genetic counseling. Analysis of your DNA can reveal whether you have the inherited gene that causes XLA. Mayo Clinic's Department of Medical Genetics can help you understand how a genetically based disorder such as XLA affects you or your child and your family.

At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.

Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.

Why Choose Mayo Clinic

What Sets Mayo Clinic Apart

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Doctors trained in allergy, asthma and clinical immunology care for adults with XLA at Mayo Clinic in Arizona.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases care for adults with XLA at Mayo Clinic in Florida.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases in the Primary Immunodeficiency Center and other areas care for people with XLA at Mayo Clinic in Minnesota.

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Doctors trained in immune system disorders and other areas conduct basic and clinical research in potential diagnostic tests and treatments for X-linked agammaglobulinemia. Staff in the Primary Immunodeficiency Center at Mayo Clinic in Minnesota conducts research in XLA and other primary immunodeficiency conditions.

Publications

See a list of publications by Mayo authors on PubMed, a service of the National Library of Medicine.

Nov. 20, 2012