Risk factorsBy Mayo Clinic Staff
Although the exact cause of vulvar cancer isn't known, certain factors appear to increase your risk of the disease, including:
Oct. 07, 2015
- Increasing age. The risk of vulvar cancer increases with age, though it can occur at any age. The average age at diagnosis is 65.
- Being exposed to human papillomavirus (HPV). HPV is a sexually transmitted infection that increases the risk of several cancers, including vulvar cancer and cervical cancer. Many young, sexually active women are exposed to HPV, but for most the infection goes away on its own. For some, the infection causes cell changes and increases the risk of cancer in the future.
- Smoking. Smoking cigarettes increases the risk of vulvar cancer.
- Being infected with the human immunodeficiency virus (HIV). This sexually transmitted virus weakens the immune system, which may make you more susceptible to HPV infections, thereby increasing your risk of vulvar cancer.
- Having a history of precancerous conditions of the vulva. Vulvar intraepithelial neoplasia is a precancerous condition that increases the risk of vulvar cancer. Most women with vulvar intraepithelial neoplasia will never develop cancer, but a small number do go on to develop invasive vulvar cancer. For this reason, your doctor may recommend treatment to remove the area of abnormal cells and periodic follow-up checks.
- Having a skin condition involving the vulva. Lichen sclerosus, which causes the vulvar skin to become thin and itchy, increases the risk of vulvar cancer.
- Niederhuber JE, et al., eds. Cancers of the cervix, vulva and vagina. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed Sept. 4, 2015.
- Lentz GM, et al. Neoplastic diseases of the vulva. In: Comprehensive Gynecology. 6th ed. Philadelphia, Pa.: Mosby Elsevier; 2012. http://www.clinicalkey.com. Accessed Sept. 4, 2015.
- Covens A, et al. Sentinel lymph node biopsy in vulvar cancer: Systemic review, meta-analysis and guideline recommendations. Gynecologic Oncology. 2015;137:351.
- Genital HPV infection — Fact sheet. Centers for Disease Control and Prevention. http://www.cdc.gov/std/HPV/STDFact-HPV.htm. Accessed Sept. 9, 2015.
- Karam A, et al. Vulvar cancer: Staging, treatment and prognosis. http://www.uptodate.com/home. Accessed Sept. 4, 2015.
- Surgery for cancer of the vulva. American Cancer Society. http://www.cancer.org/cancer/vulvarcancer/detailedguide/vulvar-cancer-treating-surgery. Accessed Sept. 9, 2015.
- Frequently asked questions. Gynecologic problems FAQ088. Disorders of the vulva. American College of Obstetrics and Gynecology. http://www.acog.org/For_Patients. Accessed Sept. 4, 2015.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. March 17, 2015.
- Edge SB, et al. AJCC Cancer Staging Manual. 7th ed. New York, N.Y.: Springer; 2010:379.