CausesBy Mayo Clinic Staff
The exact cause of vasculitis isn't fully understood. Some types are related to a person's genetic makeup. Others result from the immune system attacking blood vessel cells by mistake. Possible triggers for this immune system reaction include:
- Infections, such as hepatitis B and hepatitis C
- Blood cancers
- Immune system diseases, such as rheumatoid arthritis, lupus and scleroderma
- Reactions to certain drugs
Blood vessels affected by vasculitis may bleed or become inflamed. Inflammation can cause the layers of the blood vessel wall to thicken. This narrows the blood vessels, reducing the amount of blood — and therefore oxygen and vital nutrients — that reaches your body's tissues and organs.
Oct. 08, 2014
- What is vasculitis? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/vas/. Accessed July 16, 2014.
- Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=4. Accessed July 16, 2014.
- Gwathmey KG, et al. Vasculitic neuropathies. Lancet Neurology. 2014;13:67.
- Guillevin L. Infections in vasculitis. Best Practice & Research in Clinical Rheumatology. 2013;27:19.
- Merkel PA. Overview of the management of vasculitis in adults. http://www.uptodate.com/home. Accessed July 17, 2014.
- Tarzi R, et al. Small vessel vasculitides. Medicine. 2014;42:138.
- Ferri FF. Ferri's Clinical Advisor 2015: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2015. https://www.clinicalkey.com. Accessed July 17, 2014.
- Zand L, et al. Treatment of ANCA-associated vasculitis: New therapies and a look at old entities. Advances in Chronic Kidney Disease. 2014;21:182.
- Murphy JG, et al., eds. Mayo Clinic Cardiology: Concise Textbook. 4th ed. New York, N.Y.: Oxford University Press; 2013.
- Pipitone N, et al. Role of imaging in the diagnosis of large and medium‐sized vessel vasculitis. Rheumatic Disease Clinics of North America. 2013;39:593.
- Warrington KJ, et al. A primer on vasculitis. Minnesota Medicine. 2013;96:36.
- Weyand CM, et al. Giant-cell arteritis and polymyalgia rheumatica. New England Journal of Medicine. 2014;371:50.
- Dammacco F, et al. Therapy for hepatitis C virus-related cryoglobulinemic vasculitis. New England Journal of Medicine. 2013;369:1035.
- Grayson PC, et al. New features of disease after diagnosis in 6 forms of systemic vasculitis. Journal of Rheumatology. 2013;40:1905.
- Specks U, et al. Efficacy of remission-induction regimens for ANCA-associated vasculitis. New England Journal of Medicine. 2013;369:417.