Below are current clinical trials.2 studies in Urinary tract infection (UTI)
(open studies only).
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Women have problems with oral antibiotics, including vagina and bowel infections. Also, bacteria causing urinary infections are becoming more resistant to oral antibiotis. Placement of antibiotic directly into the bladder does not cause these problems and are at doses that are may be able to stop bacteria from being resistant to antibiotics.
Urinary catheters are used routinely in the postoperative care of urogynecology patients after surgery involving the genitourinary tract. However, Urinary tract infections(UTI) associated with indwelling catheter is the second leading cause of nosocomial infections. 20% of hospital acquired bacteremia arise from UTI with an associated mortality of 10%.
There are many different types of catheters available for use. Standard indwelling catheters are made from a variety of materials including polyvinyl chlorine, plastic, plain latex, polytetrafluoroethylene, silicone elastomer, pure silicone hydrogel and polymer hydromer. Specialized catheters have been developed with the aim of reducing infection. Strategies generally involved coating the inner, outer or both surfaces of the catheter with antimicrobial materials. These materials can be antibiotic or antiseptic with the most common antiseptic material used being silver. Silver ions are bactericidal, are used safely when applied topically to humans and used in controlling infections.
Previous studies comparing UTI rates in transurethral catheters have reported a significant reduction of UTI rate in silver-alloy catheters with a range of 5-12% compared to standard catheters with a range of 7-50%. There are no studies comparing the UTI rate in silver-alloy supra-pubic catheters to standard supra-pubic catheters. The investigators hypothesize that this study will show a statistically significant decrease in UTI rate among the individuals with a silver-alloy suprapubic catheter compared to the standard silver-alloy catheter.
Aug. 25, 2017
- Wein AJ, et al., eds. Infections of the urinary tract. In: Campbell-Walsh Urology. 11th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed June 30, 2017.
- Ferri FF. Urinary tract infection. In: Ferri's Clinical Advisor 2017. Philadelphia, Pa.: Elsevier; 2017. https://www.clinicalkey.com. Accessed June 30, 2017.
- Bladder infection (urinary tract infection—UTI) in adults. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/urologic-diseases/bladder-infection-uti-in-adults. Accessed June 30, 2017.
- Urinary tract infections (UTIs). The American College of Obstetricians and Gynecologists. https://www.acog.org/Patients/FAQs/Urinary-Tract-Infections-UTIs. Accessed June 30, 2017.
- Urinary tract infections. National Institutes of Health. https://nihseniorhealth.gov/urinarytractinfections/whatareurinarytractinfections/01.html. Accessed June 30, 2017.
- Hooton TM, et al. Acute uncomplicated cystitis and pyelonephritis in women. https://www.uptodate.com/contents/search. Accessed June 30, 2017.
- Hooton TM, et al. Recurrent urinary tract infection in women. https://www.uptodate.com/contents/search. Accessed June 30, 2017.
- Cranberry. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/cranberry. Accessed June 30, 2017.
- Takhar SS, et al. Diagnosis and management of urinary tract infection in the emergency department and outpatient settings. Infectious Disease Clinics of North America. 2014;28:33.
- Overactive bladder (OAB): Lifestyle changes. Urology Care Foundation. https://urologyhealth.org/urologic-conditions/overactive-bladder-(oab)/treatment/lifestyle-changes. Accessed July 3, 2017.
- Werner K. Allscripts EPSi. Mayo Clinic, Rochester, Minn. April 7, 2017.
- Hooper DC. Fluoroquinolones. https://www.uptodate.com/contents/search. Accessed Aug. 7, 2017.
- FDA drug safety communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. U.S. Food and Drug Administration. https://www.fda.gov/Drugs/DrugSafety/ucm511530.htm. Accessed Aug. 7, 2017.
Urinary tract infection (UTI)