Nov. 30, 2016
Below are current clinical trials.1 studies in Urinary tract infection (UTI)
(open studies only).
Filter this list of studies by location, status and more.
Urinary catheters are used routinely in the postoperative care of urogynecology patients after surgery involving the genitourinary tract. However, Urinary tract infections(UTI) associated with indwelling catheter is the second leading cause of nosocomial infections. 20% of hospital acquired bacteremia arise from UTI with an associated mortality of 10%.
There are many different types of catheters available for use. Standard indwelling catheters are made from a variety of materials including polyvinyl chlorine, plastic, plain latex, polytetrafluoroethylene, silicone elastomer, pure silicone hydrogel and polymer hydromer. Specialized catheters have been developed with the aim of reducing infection. Strategies generally involved coating the inner, outer or both surfaces of the catheter with antimicrobial materials. These materials can be antibiotic or antiseptic with the most common antiseptic material used being silver. Silver ions are bactericidal, are used safely when applied topically to humans and used in controlling infections.
Previous studies comparing UTI rates in transurethral catheters have reported a significant reduction of UTI rate in silver-alloy catheters with a range of 5-12% compared to standard catheters with a range of 7-50%. There are no studies comparing the UTI rate in silver-alloy supra-pubic catheters to standard supra-pubic catheters. The investigators hypothesize that this study will show a statistically significant decrease in UTI rate among the individuals with a silver-alloy suprapubic catheter compared to the standard silver-alloy catheter.
- Bennett JE, et al. Urinary tract infections. In: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2015. https://www.clinicalkey.com. Accessed April 20, 2015.
- Urinary tract infections in adults. National Institute of Diabetes and Digestive and Kidney Diseases. http://kidney.niddk.nih.gov/KUDiseases/pubs/utiadult/. Accessed April 15, 2015.
- Bacterial urinary tract infections. Merck Manual Professional Version. http://www.merckmanuals.com/professional/genitourinary-disorders/urinary-tract-infections-uti/bacterial-urinary-tract-infections. Accessed April 23, 2015.
- Grabe M, et al. Guidelines on urological infections. European Association of Urology. http://uroweb.org/guideline/urological-infections/. Accessed April 20, 2015.
- Hooton TM, et al. Acute uncomplicated cystitis and pyelonephritis in women. http://www.uptodate.com/home. Accessed April 20, 2015.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. April 22, 2015.
- Geerlings SE, et al. Prevention of recurrent urinary tract infections in women: Antimicrobial and nonantimicrobial strategies. Infectious Disease Clinics of North America. 2014;28:135.
- Hooton TM, et al. Recurrent urinary tract infection in women. http://www.uptodate.com/home. Accessed April 20, 2015.
- Jepson RG. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001321.pub5/abstract. Accessed April 20, 2015.
- Cranberry. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/cranberry. Accessed April 20, 2015.
- Newman DK, et al. Office-based behavioral therapy for management of incontinence and other pelvic disorders. The Urologic Clinics of North America. 2013;40:613.
- Castle EP (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. Nov. 1, 2016.
- Marnach ML (expert opinion). Mayo Clinic, Rochester, Minn. May 24, 2015.
- Juthani-Mehta M, et al. Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes. JAMA. In press. Accessed Oct. 31, 2016.