There aren't many known risk factors for type 1 diabetes, though researchers continue to find new possibilities.
Known risk factors
- A family history. Anyone with a parent or siblings with type 1 diabetes has a slightly increased risk of developing the condition.
- Genetic susceptibility. The presence of certain genes indicates an increased risk of developing type 1 diabetes. In some cases — usually through a clinical trial — genetic testing can be done to determine if a child who has a family history of type 1 diabetes is at increased risk of developing the condition.
Possible risk factors
Possible risk factors for type 1 diabetes include:
Apr. 01, 2014
- Viral exposure. Exposure to Epstein-Barr virus, coxsackie virus, rubella or cytomegalovirus may trigger the autoimmune destruction of the islet cells, or the virus may directly infect the islet cells.
- Low vitamin D levels. Research suggests that vitamin D may protect against type 1 diabetes. However, early intake of cow's milk — a common source of vitamin D — has been linked to an increased risk of type 1 diabetes.
- Other dietary factors. Drinking water that contains nitrates may increase the risk of type 1 diabetes. The timing of the introduction of cereal into a baby's diet also may affect a child's risk of type 1 diabetes. One clinical trial found that between ages 4 and 7 months appears to be the optimal time for introducing cereal.
- Your guide to diabetes: Type 1 and type 2. National Institute of Diabetes and Digestive and Kidney Diseases. http://diabetes.niddk.nih.gov/dm/pubs/type1and2/. Accessed Nov. 9, 2013.
- Diabetes mellitus (DM). The Merck Manuals: The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/diabetes_mellitus_and_disorders_of_carbohydrate_metabolism/diabetes_mellitus_dm.html. Accessed Nov. 8, 2013.
- Be healthy today; Be healthy for life. American Diabetes Association. http://www.diabetes.org/living-with-diabetes/parents-and-kids/children-and-type-2/. Accessed Nov. 5, 2013.
- Levitsky LL, et al. Epidemiology, presentation and diagnosis of diabetes mellitus type 1 in children and adolescents. http://www.uptodate.com/home. Accessed Nov. 9, 2013.
- Goldman L, et al. Goldman's Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Nov. 9, 2013.
- Position statement: Standards of medical care in diabetes — 2013. Diabetes Care. 2013;36:S11.
- Levitsky LL, et al. Management of diabetes mellitus type 1 in children and adolescents. http://www.uptodate.com/home. Accessed Nov. 9, 2013.
- Levitsky LL, et al. Complications and screening in children and adolescents with type 1 diabetes mellitus. http://www.uptodate.com/home. Accessed Nov. 9, 2013.
- Pancreas transplantation. The Merck Manuals: The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/immunology_allergic_disorders/transplantation/pancreas_transplantation.html. Accessed Nov. 9, 2013.
- Ketoacidosis. American Diabetes Association. http://www.diabetes.org/type-1-diabetes/ketoacidosis.jsp. Accessed Nov. 9, 2013.
- Diabetes. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Nov. 9, 2013.
- Castro MR (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 18, 2013.
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