Although the exact cause of transposition of the great arteries is unknown, several factors may increase the risk of a baby being born with this condition, including:

  • A history of German measles (rubella) or another viral illness in the mother during pregnancy
  • A family history of transposition of the great arteries or another congenital heart defect
  • Poor nutrition during pregnancy
  • Drinking alcohol during pregnancy
  • A mother older than age 40
  • A mother who has poorly controlled diabetes
  • Down syndrome in the baby
Aug. 10, 2012

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