Diagnosis

Tests and procedures used to diagnose toxic hepatitis include:

  • Physical exam. Your doctor will likely perform a physical exam and take a medical history. Be sure to bring to your appointment all medications you're taking, including over-the-counter drugs and herbs, in their original containers. Tell your doctor if you work with industrial chemicals or may have been exposed to pesticides, herbicides or other environmental toxins.
  • Blood tests. Your doctor may order blood tests that look for high levels of certain liver enzymes. These enzyme levels can show how well your liver is functioning.
  • Imaging tests. Your doctor may recommend an imaging test to create a picture of your liver using ultrasound, computerized tomography (CT) or magnetic resonance imaging (MRI).
  • Liver biopsy. A liver biopsy can help confirm the diagnosis of toxic hepatitis. During a liver biopsy, a needle is used to extract a small sample of tissue from your liver. The sample is examined under a microscope. Newer, noninvasive tests that confirm liver damage may be available as an alternative to liver biopsy. These tests are magnetic elastography and transient elastography.
Oct. 04, 2016
References
  1. Feldman M, et al. Hepatic drug metabolism and liver disease caused by drugs. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed Aug. 17, 2016.
  2. Couturier FJ, et al. Toxic hepatitis due to a food supplement: "Natural" is no synonym for "harmless." Clinics and Research in Hepatology and Gastroenterology. In press. Accessed Aug. 17, 2016.
  3. McNally PR, ed. Alcoholic liver disease, alcoholism, and alcohol withdrawal. In: GI/Liver Secrets Plus. 5th ed. Philadelphia, Pa.: Saunders Elsevier; 2015. http://www.clinicalkey.com. Accessed Aug. 17, 2016.
  4. Larson AM. Drug-induced liver injury. http://www.uptodate.com/home. Accessed Aug. 17, 2016.
  5. Larson AM. Hepatotoxicity due to herbal medications and dietary supplements. http://www.uptodate.com/home. Accessed Aug. 17, 2016.
  6. Brown, AC. Liver toxicity related to herbs and dietary supplements: Online table of case reports. Part 3 of 6, Food and Chemical Toxicology. In press. Accessed Aug. 20, 2016.
  7. Feldman M, et al. Liver disease caused by anesthetics, chemicals, toxins, and herbal preparations. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed Aug. 17, 2016.
  8. Picco MF (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 29, 2016.