It's not clear what causes thyroid cancer.
Thyroid cancer occurs when cells in your thyroid undergo genetic changes (mutations). The mutations allow the cells to grow and multiply rapidly. The cells also lose the ability to die, as normal cells would. The accumulating abnormal thyroid cells form a tumor. The abnormal cells can invade nearby tissue and can spread throughout the body.
Types of thyroid cancer
The type of thyroid cancer you have determines treatment and prognosis. Types of thyroid cancer include:
April 14, 2014
- Papillary thyroid cancer. The most common form of thyroid cancer, papillary cancer arises from follicular cells, which produce and store thyroid hormones. Papillary thyroid cancer can occur at any age, but most often it affects people ages 30-50.
- Follicular thyroid cancer. Follicular cancer also arises from the follicular cells of the thyroid. It usually affects people older than age 50. Hurthle cell cancer is a rare and potentially more aggressive type of follicular thyroid cancer.
- Medullary thyroid cancer. Medullary thyroid cancer begins in thyroid cells called C cells that produce the hormone calcitonin. Elevated levels of calcitonin in the blood can detect medullary thyroid cancer at a very early stage. Certain genetic syndromes increase the risk of medullary thyroid cancer, although this genetic link is uncommon.
- Anaplastic thyroid cancer. Anaplastic thyroid cancer is a rare and rapidly growing cancer that is very difficult to treat. Anaplastic thyroid cancer typically occurs in adults age 60 or older.
- Thyroid lymphoma. Thyroid lymphoma is a rare form of thyroid cancer that begins in the immune system cells in the thyroid and grows very quickly. Thyroid lymphoma typically occurs in older adults.
- Melmed S, et al. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. https://www.clinicalkey.com. Accessed Dec. 18, 2013.
- Thyroid carcinoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Dec. 18, 2013.
- Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Falls Church, Va.: American Thyroid Association. http://thyroidguidelines.net/revised/taskforce. Accessed Dec. 18, 2013.
- Niederhuber JE, et al., eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed Dec. 18, 2013.
- What you need to know about thyroid cancer. National Cancer Institute. http://www.cancer.gov/cancertopics/wyntk/thyroid. Accessed Dec. 18, 2013.
- Guidelines for patients receiving radioiodine I-131 treatment. Society for Nuclear Medicine and Molecular Imaging. http://interactive.snm.org/index.cfm?PageID=11031. Accessed Dec. 24, 2013.
- Hay ID, et al. The coming of age of ultrasound-guided percutaneous ethanol ablation of selected neck nodal metastases in well-differentiated thyroid carcinoma. Journal of Clinical Endocrinology & Metabolism. 2011;96:2717.
- Caprelsa (prescribing information). Wilmington, Del.: AstraZeneca Pharmaceuticals; 2013. http://www.caprelsa.com. Accessed Dec. 24, 2013.
- Cometriq (prescribing information). South San Francisco, Calif.: Exelixis Inc.; 2012. http://www.cometriq.com. Accessed Dec. 24, 2013.
- Frequently asked questions about potassium iodide. U.S. Nuclear Regulatory Commission. http://www.nrc.gov/about-nrc/emerg-preparedness/about-emerg-preparedness/potassium-iodide/ki-faq.html. Accessed Dec. 24, 2013.
- Brito JP, et al. Thyroid cancer: Zealous imaging has increased detection and treatment of low risk tumors. BMJ. 2013;347:f4706.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. Sept. 24, 2013.
- Nippoldt TB (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 5, 2014.
- Morris JC (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 6, 2014.
- Nexavar (prescribing information). Whippany, N.J.: Bayer HealthCare Pharmaceuticals Inc.; 2013. http://www.nexavar-us.com. Accessed Jan. 8, 2014.
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