Treatment for systemic mastocytosis varies depending on the type you have. Basic components of most systemic mastocytosis treatment plans include:
- Treating and controlling symptoms. Mayo Clinic doctors will help you identify particular factors that may trigger your symptoms of systemic mastocytosis, such as certain foods, medications, insect stings or temperature changes. They will also work with you to help keep your systemic mastocytosis symptoms under control with medications, such as antihistamines, aspirin and certain drugs that will counteract the effects of the substances released by your mast cells — such as corticosteroids and leukotriene agonists. Your health care team may also teach you how to give yourself an epinephrine injection in the event you have a severe allergic response when your mast cells are triggered.
- Regular monitoring. Your Mayo Clinic doctors will regularly collect blood and urine samples from you to monitor the status of your condition. Mayo Clinic is one of the only centers to offer a special home kit that you can use to collect blood and urine samples while you're experiencing symptoms, which gives your doctor a better picture of how systemic mastocytosis affects your body.
- Bone density measurements. Because systemic mastocytosis can affect your bones and bone marrow, you may be at risk for bone problems, such as osteoporosis. At Mayo Clinic, bone density measurements every two years are a regular component of your treatment.
If you have the aggressive form of systemic mastocytosis, or mastocytosis associated with another blood disorder, you may be treated with chemotherapy medications, which reduce the number of mast cells. Chemotherapy treatment length varies depending on your specific condition, how well you respond to treatment and how well you tolerate it.
April 29, 2015
- Butterfield JH (expert opinion). Mayo Clinic, Rochester, Minn. March 2, 2015.
- Pardanani A. Systemic mastocytosis in adults: 2013 update on diagnosis, risk stratification, and management. American Journal of Hematology. 2013;88:613.
- Systemic mastocytosis. American Academy of Allergy, Asthma and Immunology. http://www.aaaai.org/conditions-and-treatments/related-conditions/systemic-mastocytosis.aspx. Accessed Feb. 12, 2015.
- Mastocytosis explained. The Mastocytosis Society, Inc. http://tmsforacure.org/patients/mastocytosis_explained_2.php. Accessed Feb. 12, 2015.
- Akin C, et al. Diagnosis and classification of mastocytosis. Immunology and Allergy Clinics of North America. 2014;34:207.
- Siebenhaar F, et al. Treatment strategies in mastocytosis. Immunology and Allergy Clinics of North America. 2014;34:433.
- Golden AK. Decision Support System. Mayo Clinic, Rochester, Minn. Feb.17, 2015.
- Weiler CR (expert opinion). Mayo Clinic, Rochester, Minn. March 12, 2015.
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