Diagnosis at Mayo Clinic

By Mayo Clinic Staff


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Diagnosis of systemic mastocytosis can be confirmed by finding high numbers of mast cells or high levels of the substances they release in your body, such as tryptase, histamine or prostaglandins. Tests your doctor may use to confirm systemic mastocytosis include:

  • Bone marrow biopsy. A small amount of your bone marrow tissue will be analyzed for increased numbers of mast cells, if this test has not been done already.
  • Blood tests. A low number of red blood cells (anemia) or a high number of a type of white blood cells called eosinophils may indicate systemic mastocytosis.
  • Urine tests. High levels of histamine and prostaglandins in your urine may also indicate systemic mastocytosis.
  • Imaging tests. X-rays, ultrasounds and computerized tomography (CT) scans help to determine the extent and stage of your condition by providing a picture of your insides, revealing possible bone or organ involvement.
Nov. 20, 2012

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