Diagnosis at Mayo Clinic

By Mayo Clinic Staff


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Diagnosis of systemic mastocytosis can be confirmed by finding high numbers of mast cells or high levels of the substances they release in your body, such as tryptase, histamine products, leukotrienes or prostaglandins. Tests your doctor may use to confirm systemic mastocytosis include:

  • Bone marrow biopsy. This is the most common test. A small amount of your bone marrow tissue will be analyzed for increased numbers of mast cells. Your doctor will also look for specific genetic changes in your bone marrow cells.
  • Blood tests. A serum test for a mast cell enzyme called tryptase will be checked. A low number of red blood cells (anemia) or a high number of a type of white blood cells called eosinophils may indicate systemic mastocytosis.
  • Urine tests. High levels of histamine products, leukotrienes or prostaglandins in your urine may also indicate systemic mastocytosis.
  • Imaging tests. X-rays, ultrasounds and computerized tomography (CT) scans help determine the extent and stage of your condition by providing a picture of your insides, revealing possible bone or organ involvement.
April 29, 2015