Diagnosis of systemic mastocytosis can be confirmed by finding high numbers of mast cells or high levels of the substances they release in your body, such as tryptase, histamine products, leukotrienes or prostaglandins. Tests your doctor may use to confirm systemic mastocytosis include:
April 29, 2015
- Bone marrow biopsy. This is the most common test. A small amount of your bone marrow tissue will be analyzed for increased numbers of mast cells. Your doctor will also look for specific genetic changes in your bone marrow cells.
- Blood tests. A serum test for a mast cell enzyme called tryptase will be checked. A low number of red blood cells (anemia) or a high number of a type of white blood cells called eosinophils may indicate systemic mastocytosis.
- Urine tests. High levels of histamine products, leukotrienes or prostaglandins in your urine may also indicate systemic mastocytosis.
- Imaging tests. X-rays, ultrasounds and computerized tomography (CT) scans help determine the extent and stage of your condition by providing a picture of your insides, revealing possible bone or organ involvement.
- Butterfield JH (expert opinion). Mayo Clinic, Rochester, Minn. March 2, 2015.
- Pardanani A. Systemic mastocytosis in adults: 2013 update on diagnosis, risk stratification, and management. American Journal of Hematology. 2013;88:613.
- Systemic mastocytosis. American Academy of Allergy, Asthma and Immunology. http://www.aaaai.org/conditions-and-treatments/related-conditions/systemic-mastocytosis.aspx. Accessed Feb. 12, 2015.
- Mastocytosis explained. The Mastocytosis Society, Inc. http://tmsforacure.org/patients/mastocytosis_explained_2.php. Accessed Feb. 12, 2015.
- Akin C, et al. Diagnosis and classification of mastocytosis. Immunology and Allergy Clinics of North America. 2014;34:207.
- Siebenhaar F, et al. Treatment strategies in mastocytosis. Immunology and Allergy Clinics of North America. 2014;34:433.
- Golden AK. Decision Support System. Mayo Clinic, Rochester, Minn. Feb.17, 2015.
- Weiler CR (expert opinion). Mayo Clinic, Rochester, Minn. March 12, 2015.
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