Diagnosis at Mayo ClinicBy Mayo Clinic Staff
Systemic capillary leak syndrome is difficult to diagnose. You may undergo blood and urine tests and imaging studies. Your doctors may diagnose sudden, periodic "attacks" of this condition by seeing the following signs, symptoms and laboratory abnormalities and excluding other conditions that could cause them:
Nov. 26, 2014
- Concentrated blood
- Low serum albumin in the blood
- Presence of a distinct monoclonal protein in the blood or urine
- Generalized body swelling
- Muscle aches
- Decreased or dark urine
- Druey KM, et al. Narrative review: The systemic capillary leak syndrome. Annals of Internal Medicine. 2010;153:90.
- Kapoor P, et al. Idiopathic systemic capillary leak syndrome (Clarkson's disease): The Mayo Clinic Experience. Mayo Clinic Proceedings. 2010;85:905.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. June 25, 2014.
- Gousseff M, et al. The systemic capillary leak syndrome: A case series of 28 patients from a European registry. Annals of Internal Medicine 2011;154:464.
- Xie Z, et al. Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood. 2012;119:4321.