Oct. 08, 2014
Below are current clinical trials.5 studies in Spinal cord injury
(open studies only).
Filter this list of studies by location, status and more.
This will be a prospective registry conducted and maintained at Mayo Clinic Rochester from which collaborating sites within Mayo, Mayo Health Systems, and other spinal cord injury centers can draw from in order to fulfill research enrollment.The purpose is to generate data from this group of subjects pertaining to physical activities and the secondary consequences of using a wheelchair, to allow future research on preventative measures to aid in a better quality of life within this population.
This is a feasibility study to test the use of epidural stimulation to restore volitional function previously lost due to spinal cord injury. Previous studies conducted in animal models, performed elsewhere and here at Mayo Clinic, have shown that direct electrical stimulation of the spinal cord increases the excitability of spared neuronal connections within the site of injury, thereby enhancing signal transmission and allowing recovery of previously lost volitional function. Recently, epidural electrical stimulation of the lumbosacral spinal cord in four individuals with spinal cord injury (SCI) has restored motor and autonomic function below the level of injury. Despite positive results, further translational research is needed to validate these findings. The goal of this proposal is to perform epidural stimulation to restore volitional function in patients with SCI. In two patients, we will implant an epidural stimulator onto the dorsal aspect of the lumbosacral spinal cord dura mater. Patients will undergo a structured program of daily physical rehabilitation, treadmill step training, and epidural stimulation to recover motor, sensory, and autonomic function.
The aim of this study is to evaluate efficacy and safety of riluzole in the treatment of patients with acute SCI. The primary objective is to evaluate the superiority of riluzole, at a dose of 2 x 100 mg the first 24 hours followed by 2 x 50 mg for the following 13 days after injury, as compared to placebo, in change between 180 days and baseline in motor outcomes as measured by International Standards for Neurological Classification of Spinal Cord Injury Examination (ISNCSCI) Motor Score, in patients with acute traumatic SCI, presenting to the hospital less than 12 hours after injury. Secondary objectives are to evaluate the effects of riluzole on overall neurologic recovery, sensory recovery, functional outcomes, quality of life outcomes, health utilities, mortality, and adverse events. The working hypothesis is that the riluzole treated subjects will experience superior motor, sensory, functional, and quality of life outcomes as compared to those receiving placebo, with an acceptable safety profile.
The purpose of this study is to develop a pattern recognition algorithm for manual wheelchair related activities of daily living. This study also aims to identify shoulder impingement risk score of MWC-related ADLs and determine cumulative shoulder impingement risk of MWC-related ADLs.
The purpose of this USA Hockey registry is to collect information on the prevalence of catastrophic injuries for both genders in youth, high school, junior, college, national program, adult amateur, minor league, and professional ice hockey in the United States. The goal is to design and maintain a comprehensive registry of catastrophic injuries in ice hockey that will be the primary source of catastrophic ice hockey injury data in the United States. The registry will provide data to support potential rule and equipment changes.
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- Hansebout RR, et al. Acute traumatic spinal cord injury. http://www.uptodate.com/home. Accessed July 9, 2014.
- Spinal trauma. The Merck Manuals: The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/injuries_poisoning/spinal_trauma/spinal_trauma.html. Accessed July 9, 2014.
- Spinal cord injury facts. American Association of Neurological Surgeons. http://www.aans.org/Patient%20Information/Fact%20Sheets.aspx. Accessed July 9, 2014.
- Spinal cord injury facts and figures at a glance. National Spinal Cord Injury Statistical Center. https://www.nscisc.uab.edu/. Accessed July 9, 2014.
- Spinal cord injury prevention tips. American Association of Neurological Surgeons. http://www.aans.org/Patient%20Information/~/media/Files/Patient%20Information/Patient%20Safety%20Tips/spinal_cord_injury_prevention.ashx. Accessed July 9, 2014.
- Vodusek DB. Lower urinary tract and sexual dysfunction in neurological patients. European Neurology. 2014;72:109.
- Spinal cord injury: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/sci/detail_sci.htm. Accessed July 9, 2014.