Risk factorsBy Mayo Clinic Staff
Although doctors and researchers don't know for sure why spina bifida occurs, they have identified a few risk factors:
- Race. Spina bifida is more common among whites and Hispanics.
- Sex. Girls are affected more often.
Family history of neural tube defects. Couples who've had one child with a neural tube defect have a slightly higher chance of having another baby with the same defect. That risk increases if two previous children have been affected by the condition.
In addition, a woman who was born with a neural tube defect, or who has a close relative with one, has a greater chance of giving birth to a child with spina bifida. However, most babies with spina bifida are born to parents with no known family history of the condition.
- Folate deficiency. Folate (vitamin B-9) is important to the healthy development of a baby. Folate is the natural form of vitamin B-9. The synthetic form, found in supplements and fortified foods, is called folic acid. A folate deficiency increases the risk of spina bifida and other neural tube defects.
- Some medications. Anti-seizure medications, such as valproic acid (Depakene), seem to cause neural tube defects when taken during pregnancy, perhaps because they interfere with the body's ability to use folate and folic acid.
- Diabetes. Women with diabetes who don't control their blood sugar well have a higher risk of having a baby with spina bifida.
- Obesity. Pre-pregnancy obesity is associated with an increased risk of neural tube birth defects, including spina bifida.
- Increased body temperature. Some evidence suggests that increased body temperature (hyperthermia) in the early weeks of pregnancy may increase the risk of spina bifida. Elevating your core body temperature, due to fever or the use of saunas or hot tubs, has been associated with increased risk of spina bifida.
If you have known risk factors for spina bifida, talk with your doctor to determine if you need a larger dose or prescription dose of folic acid, even before a pregnancy begins.
If you take medications, tell your doctor. Some medications can be adjusted to diminish the potential risk of spina bifida, if plans are made ahead of time.
Aug. 27, 2014
- Spina bifida: Facts. Centers for Disease Control and Prevention. http://www.cdc.gov/NCBDDD/spinabifida/facts.html. Accessed June 13, 2014.
- Spina bifida fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/spina_bifida/detail_spina_bifida.htm. Accessed June 13, 2014.
- Fieggen G, et al. Spina bifida: A multidisciplinary perspective on a many-faceted condition. South African Medical Journal. 2014;104:213.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed June 13, 2014.
- McLone DG, et al. Pathophysiology and clinical manifestations of myelomeningocele (spina bifida). http://www.uptodate.com/home. Accessed June 13, 2014.
- Second trimester maternal serum screening. LabTestsOnline. http://labtestsonline.org/understanding/analytes/triple-screen/tab/sample/. Accessed June 16, 2014.
- Hochberg L, et al. Prenatal screening and diagnosis for neural tube defects. http://www.uptodate.com/home. Accessed June 16, 2014.
- Grivell RM, et al. Repair procedures for spina bifida for improving infant and maternal outcomes (Protocol). Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008825/abstract. Accessed June 16, 2014.
- McLone DG, et al. Overview of the management of myelomeningocele (spina bifida). http://www.uptodate.com/home. Accessed June 13, 2014.
- Dietary supplement fact sheet: Folate. Office of Dietary Supplements. http://ods.od.nih.gov/factsheets/folate. Accessed June 13, 2014.
- Riggin EA. Decision Support System. Mayo Clinic, Rochester, Minn. June 12, 2014.