Treatments and drugs

By Mayo Clinic Staff

The only sure way to prevent an allergic reaction to shellfish is to avoid shellfish. But despite your best efforts, you may come into contact with shellfish.

Your doctor may instruct you to treat a mild allergic reaction to shellfish, with medications such as antihistamines to reduce signs and symptoms, such as rash and itchiness.

If you have a severe allergic reaction to shellfish (anaphylaxis), you'll likely need an emergency injection of epinephrine (adrenaline). If you're at risk of having a severe reaction, carry injectable epinephrine (EpiPen, Auvi-Q, others) with you at all times. If you're at risk for anaphylaxis to shellfish, your doctor may instruct you to administer epinephrine even at the first sign of an allergic reaction. After you use epinephrine, seek emergency medical care.

Jul. 12, 2014

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