Selective IgA deficiency is an immune system condition in which you lack or don't have enough immunoglobulin A (IgA), a protein that fights infection (antibody). Most people with selective IgA deficiency don't have recurrent infections. However, some people who have IgA deficiency experience recurrent respiratory tract infections, asthma, sinus infections, allergies and diarrhea.

Selective IgA deficiency may also be found with autoimmune disease, in which your immune system attacks itself. Common autoimmune conditions found with IgA deficiency include rheumatoid arthritis, lupus and celiac disease.

  • Expertise. Mayo Clinic doctors trained in immune system disorders have experience in caring for people with selective IgA deficiency and other primary immunodeficiency conditions. The Primary Immunodeficiency Center at Mayo Clinic in Minnesota is a designated referral center for the Jeffrey Modell Foundation — a nonprofit organization that promotes and conducts research for primary immunodeficiency disorders.
  • Personalized care. Most people with selective IgA deficiency don't receive treatment unless they have recurrent infections. Your Mayo Clinic doctor will work closely with you to recognize and treat infections as soon as they occur. In some cases, you may need a long course of antibiotics to prevent an infection from returning.

At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.

Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.

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Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Doctors trained in allergy, asthma and clinical immunology care for adults with selective IgA deficiency at Mayo Clinic in Arizona.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases care for adults with selective IgA deficiency at Mayo Clinic in Florida.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Doctors trained in immune conditions and allergic diseases in the Primary Immunodeficiency Center and other areas care for people with selective IgA deficiency at Mayo Clinic in Minnesota.

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Staff in the Primary Immunodeficiency Center at Mayo Clinic in Minnesota conducts basic and clinical research in selective IgA deficiency and other primary immunodeficiency conditions.

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See a list of publications by Mayo authors on PubMed, a service of the National Library of Medicine.

Nov. 19, 2012