Below are current clinical trials.6 studies in Scoliosis
(open studies only).
Filter this list of studies by location, status and more.
The purpose of this study is to evaluate patient and parent willingness to participate in a proposed randomized controlled trial evaluating a low vs. high implant density for surgical treatment of scoliosis.
- Primary objective: Determine if there is a clinically significant difference in percent Cobb curve correction in a low- vs. high-implant density cohort through a prospective randomized controlled trial.
Design and Outcomes
- Randomized clinical trial of equivalence to test the efficacy and safety of low vs. high implant density instrumentation for spine deformity surgery in AIS patients with Lenke IA curve patterns.
Interventions and Duration
- Intervention: low-implant density group or high-implant density group.
- Duration: 2 years.
Sample Size and Population
- Target population: 10 to 17 years old with AIS who will undergo instrumented spinal fusion.
- Sample size needed (power = 90%) is 174 subjects with 87 in each group.
The purpose of this study is to identify the epigenetic profiles associated with scoliosis progression.
The purpose of this study is to determine pre-surgical and post-surgical changes in gait stability and free-living activity. The information collected in this study will be used to guide surgical interventions and achieve better functional outcomes.
This study will explore the relationship between skeletal muscle and physical activity in scoliosis patients to provide insight into both the etiology of scoliosis and possible ways to mitigate the potential harm of treatment.
The purpose of this study is to gather samples for identifying genetic factors that make children susceptible to ideopathic scoliosis and influence disease progression.
Aug. 15, 2017
- Questions and answers about scoliosis in children and adolescents. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Scoliosis. Accessed Feb. 2, 2016.
- Introduction to scoliosis. American Academy of Orthopaedic Surgeons. http://orthoinfo.aaos.org/topic.cfm?topic=A00633. Accessed Feb. 2, 2016.
- Kliegman RM, et al. The spine. In: Nelson Textbook of Pediatrics. 20th ed. Philadelphia, Pa.: Elsevier; 2016. http://www.clinicalkey.com. Accessed Feb. 2, 2016.
- Scherl SA. Adolescent idiopathic scoliosis: Clinical features, evaluation and diagnosis. http://www.uptodate.com/home. Accessed Feb. 2, 2016.
- Scherl SA. Adolescent idiopathic scoliosis: Management and prognosis. http://www.uptodate.com/home. Accessed Feb. 2, 2016.
- Shaughnessy WJ (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 20, 2016.
- Shands AR. End result of the treatment of idiopathic scoliosis. Journal of Bone and Joint Surgery. 1941;23:963.
- Brown AY. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Feb. 8, 2016.